Pharmacological bypass of NAD + salvage pathway protects neurons from chemotherapy-induced degeneration

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648

Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

Bieganowski, P., & Brenner, C. (2004) · Cell · doi:10.1016/s0092-8674(04)00416-7 · Cited by 750

Chemotherapy‐induced peripheral neurotoxicity: A critical analysis

Park, S. B., Goldstein, D., Krishnan, A. V., Lin, C. S.-Y., Friedlander, M. L., Cassidy, J., Koltzenburg, M., & Kiernan, M. C. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21204 · Cited by 745

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

Osterloh, J. M., Yang, J. H., Rooney, T. M., Fox, A. N., Adalbert, R., Powell, E. H., Sheehan, A. E., Avery, M. A., Hackett, R., Logan, M. A., et al. (2012) · Science · doi:10.1126/science.1223899 · Cited by 688

Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

Lunn, E. R., Perry, V. H., Brown, M. C., Rosen, H., & Gordon, S. (1989) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1989.tb00771.x · Cited by 646

Wallerian degeneration: an emerging axon death pathway linking injury and disease

Conforti, L., Gilley, J., & Coleman, M. P. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3680 · Cited by 630

The SARM1 toll/interleukin-1 receptor domain possesses intrinsic NAD(+) cleavage activity that promotes pathological axonal degeneration

Essuman, K., Summers, D. W., Sasaki, Y., Mao, X., DiAntonio, A., & Milbrandt, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.022 · Cited by 619

Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene

Mack, T. G. A., Reiner, M., Beirowski, B., Mi, W., Emanuelli, M., Wagner, D., Thomson, D., Gillingwater, T., Court, F., Conforti, L., et al. (2001) · Nature Neuroscience · doi:10.1038/nn770 · Cited by 611

SARM1 activation triggers axon degeneration locally via NAD + destruction

Gerdts, J., Brace, E. J., Sasaki, Y., DiAntonio, A., & Milbrandt, J. (2015) · Science · doi:10.1126/science.1258366 · Cited by 593

REVERSIBLE ENZYMATIC SYNTHESIS OF DIPHOSPHOPYRIDINE NUCLEOTIDE AND INORGANIC PYROPHOSPHATE

Kornberg, A. (1950) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56513-3 · Cited by 503

NAD+ in Brain Aging and Neurodegenerative Disorders

Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.001 · Cited by 790

Programmed axon degeneration: from mouse to mechanism to medicine

Coleman, M. P., & Höke, A. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0269-3 · Cited by 329

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

Figley, M. D., Gu, W., Nanson, J. D., Shi, Y., Sasaki, Y., Cunnea, K., Malde, A. K., Jia, X., Luo, Z., Saikot, F. K., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.02.009 · Cited by 324

Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications

Gasperi, V., Sibilano, M., Savini, I., & Catani, M. V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040974 · Cited by 286

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

Tribble, J. R., Otmani, A., Sun, S., Ellis, S. A., Cimaglia, G., Vohra, R., Jöe, M., Lardner, E., Venkataraman, A. P., Domínguez‐Vicent, A., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101988 · Cited by 236

Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity

Heer, C. D., Sanderson, D. J., Voth, L. S., Alhammad, Y. M. O., Schmidt, M. S., Trammell, S. A. J., Perlman, S., Cohen, M. S., Fehr, A. R., & Brenner, C. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015138 · Cited by 192

Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism

Hong, W., Mo, F., Zhang, Z., Huang, M., & Wei, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00246 · Cited by 182

SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling

Liu, H., Zhang, J., Xu, X., Lu, S., Yang, D., Xie, C., Jia, M., Zhang, W., Jin, L., Wang, X., et al. (2021) · Theranostics · doi:10.7150/thno.49054 · Cited by 162

Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program

Geisler, S., Doan, R. A., Cheng, G., Cetinkaya‐Fisgin, A., Huang, S. X., Höke, A., Milbrandt, J., & DiAntonio, A. (2019) · JCI Insight · doi:10.1172/jci.insight.129920 · Cited by 146

The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease

Figley, M. D., & DiAntonio, A. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.02.012 · Cited by 144

Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells

Cambronne, X. A., & Kraus, W. L. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.05.010 · Cited by 137

Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1

Bratkowski, M. A., Xie, T., Thayer, D. A., Lad, S., Mathur, P., Yang, Y.-S., Danko, G., Burdett, T. C., Danao, J., Cantor, A. J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107999 · Cited by 132

Chemotherapy-induced peripheral neuropathy: part 1—current state of knowledge and perspectives for pharmacotherapy

Sałat, K. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00109-y · Cited by 131

Structural basis for SARM1 inhibition and activation under energetic stress

Sporny, M., Guez-Haddad, J., Khazma, T., Yaron, A., Dessau, M., Shkolnisky, Y., Mim, C., Isupov, M. N., Zalk, R., Hons, M., et al. (2020) · eLife · doi:10.7554/elife.62021 · Cited by 119

Chemotherapy-Induced Peripheral Neuropathy: Mechanisms and Therapeutic Avenues

Bae, E. H., Greenwald, M. K., & Schwartz, A. G. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01142-2 · Cited by 125

cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons

Sasaki, Y., Engber, T. M., Hughes, R. O., Figley, M. D., Wu, T., Bosanac, T., Devraj, R. V., Milbrandt, J., Krauss, R., & DiAntonio, A. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113252 · Cited by 111

Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity

Yang, L., Shen, J., Liu, C., Kuang, Z., Tang, Y., Qian, Z., Guan, M., Yang, Y., Zhan, Y., Li, N., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36543-8 · Cited by 104

SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites

Angeletti, C., Amici, A., Gilley, J., Loreto, A., Trapanotto, A. G., Antoniou, C., Merlini, E., Coleman, M. P., & Orsomando, G. (2022) · iScience · doi:10.1016/j.isci.2022.103812 · Cited by 95

Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy

DiAntonio, A. (2019) · Pain · doi:10.1097/j.pain.0000000000001528 · Cited by 84

Keeping the balance in NAD metabolism

Strømland, Ø., Niere, M., Nikiforov, A. A., VanLinden, M. R., Heiland, I., & Ziegler, M. (2019) · Biochemical Society Transactions · doi:10.1042/bst20180417 · Cited by 73

Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid storm

Wang, Y., Ge, M., Wang, J., Xu, Y., Wang, N., & Xu, S. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08114-w · Cited by 83

Identification of evolutionary and kinetic drivers of NAD-dependent signaling

Bockwoldt, M., Houry, D., Niere, M., Gossmann, T. I., Reinartz, I., Schug, A. H., Ziegler, M., & Heiland, I. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902346116 · Cited by 68

Inflammation-induced mitochondrial and metabolic disturbances in sensory neurons control the switch from acute to chronic pain

Willemen, H. L. D. M., Ribeiro, P. S. S., Broeks, M. H., Meijer, N. W. F., Versteeg, S., Tiggeler, A., de Boer, T. P., Małecki, J., Falnes, P. Ø., Jans, J. J. M., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101265 · Cited by 67

Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases

Hikosaka, K., Yaku, K., Okabe, K., & Nakagawa, T. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1637504 · Cited by 62

Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells

Kropotov, A., Kulikova, V., Nerinovski, K., Yakimov, A. P., Svetlova, M., Solovjeva, L., Sudnitsyna, J. S., Migaud, M. E., Khodorkovskiy, M., Ziegler, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031391 · Cited by 63

CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

Higashida, H., Hashii, M., Tanaka, Y., Matsukawa, S., Higuchi, Y., Gabata, R., Tsubomoto, M., Seishima, N., Teramachi, M., Kamijima, T., et al. (2019) · Cells · doi:10.3390/cells9010062 · Cited by 58

NAD+ Metabolism and Regulation: Lessons From Yeast

Croft, T., Venkatakrishnan, P., & Lin, S.-J. (2020) · Biomolecules · doi:10.3390/biom10020330 · Cited by 62

The Drama of Wallerian Degeneration: The Cast, Crew, and Script

Zhang, K., Jiang, M., & Fang, Y. (2021) · Annual Review of Genetics · doi:10.1146/annurev-genet-071819-103917 · Cited by 59

Sarm1 loss reduces axonal damage and improves cognitive outcome after repetitive mild closed head injury

Maynard, M. E., Redell, J. B., Zhao, J., Hood, K. N., Vita, S. M., Kobori, N., & Dash, P. K. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113207 · Cited by 55

Emerging Pharmacological and Non-Pharmacological Therapeutics for Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy

Li, Y., Lustberg, M. B., & Hu, S. (2021) · Cancers · doi:10.3390/cancers13040766 · Cited by 50

Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunityPreprint

Heer, C. D., Sanderson, D. J., Voth, L. S., Alhammad, Y. M. O., Schmidt, M. S., Trammell, S. A. J., Perlman, S. M., Cohen, M. S., Fehr, A. R., & Brenner, C. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.17.047480 · Cited by 50

Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors

She, J., Sheng, R., & Qin, Z. (2021) · Aging and Disease · doi:10.14336/ad.2021.0523 · Cited by 50

Deletion of enzymes for de novo NAD + biosynthesis accelerated ovarian aging

Yang, Q., Li, H., Wang, H., Chen, W., Zeng, X., Luo, X., Xu, J., & Sun, Y. (2023) · Aging Cell · doi:10.1111/acel.13904 · Cited by 50

Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy

Pero, M. E., Meregalli, C., Qu, X., Shin, G. J.-E., Kumar, A., Shorey, M., Rolls, M. M., Tanji, K., Brannagan, T. H., Alberti, P., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2012685118 · Cited by 49

SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration

Ozaki, E., Gibbons, L., Neto, N. G. B., Kenna, P. F., Carty, M., Humphries, M. M., Humphries, P., Campbell, M., Monaghan, M. G., Bowie, A., et al. (2020) · Life Science Alliance · doi:10.26508/lsa.201900618 · Cited by 43

Injury-Induced Inhibition of Bystander Neurons Requires dSarm and Signaling from Glia

Hsu, J.-M., Kang, Y., Corty, M. M., Mathieson, D., Peters, O. M., & Freeman, M. R. (2020) · Neuron · doi:10.1016/j.neuron.2020.11.012 · Cited by 45

SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells

Lu, M., Busquets, J., Impedovo, V., Wilson, C. N., Chan, H., Chang, Y.-T., Matsui, W. H., Tiziani, S., & Cambronne, X. A. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.01.013 · Cited by 47

Wallerian degeneration as a therapeutic target in traumatic brain injury

Koliatsos, V. E., & Alexandris, A. S. (2019) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000763 · Cited by 43

NAD+ Metabolism, Metabolic Stress, and Infection

Groth, B., Venkatakrishnan, P., & Lin, S.-J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.686412 · Cited by 42

Vincristine- and bortezomib-induced neuropathies – from bedside to bench and back

Geisler, S. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113519 · Cited by 42

Nicotinamide adenine dinucleotide treatment alleviates the symptoms of experimental autoimmune encephalomyelitis by activating autophagy and inhibiting the NLRP3 inflammasome

Wang, X., Li, B., Liu, L., Zhang, L., Ma, T., & Guo, L. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107092 · Cited by 40

A Novel Role of CD38 and Oxytocin as Tandem Molecular Moderators of Human Social Behavior

Tolomeo, S., Chiao, B., Lei, Z., Chew, S. H., & Ebstein, R. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.013 · Cited by 40

Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection

Sasaki, Y., Zhu, J., Shi, Y. Y., Gu, W., Kobe, B., Ve, T., DiAntonio, A., & Milbrandt, J. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113842 · Cited by 39

Mechanisms of injury-induced axon degeneration

Ding, C., & Hammarlund, M. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.03.006 · Cited by 37

Tumor-infiltrating nerves: unraveling the role of cancer neuroscience in tumorigenesis, disease progression, and emerging therapies

Wang, X., Fan, Y., Wang, Q., Shu, X., Lin, J., Guo, J., Li, Z., & Xu, J. (2025) · Discover Oncology · doi:10.1007/s12672-025-02827-2 · Cited by 31

Nicotinamide Adenine Dinucleotide Metabolome Is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol‐Related Liver Disease

Parker, R., Schmidt, M. S., Cain, O. L., Gunson, B. K., & Brenner, C. (2020) · Hepatology Communications · doi:10.1002/hep4.1530 · Cited by 29

Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD+ and ATP

Yang, T., Wang, Y., Liao, W., Zhang, S., Wang, S., Xu, N., Xie, W., Luo, C., Wang, Y., Wang, Z., et al. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00705-2 · Cited by 30

Traumatic axonopathy in spinal tracts after impact acceleration head injury: Ultrastructural observations and evidence of SARM1-dependent axonal degeneration

Alexandris, A. S., Lee, Y., Lehar, M., Alam, Z., Samineni, P., Tripathi, S. J., Ryu, J., & Koliatsos, V. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114252 · Cited by 25

Phagocytosis and self-destruction break down dendrites of Drosophila sensory neurons at distinct steps of Wallerian degeneration

Ji, H., Sapar, M. L., Sarkar, A., Wang, B., & Han, C. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111818119 · Cited by 28

SARM1-Dependent Axon Degeneration: Nucleotide Signaling, Neurodegenerative Disorders, Toxicity, and Therapeutic Opportunities

McGuinness, H. Y., Gu, W., Shi, Y. Y., Kobe, B., & Ve, T. (2023) · The Neuroscientist · doi:10.1177/10738584231162508 · Cited by 29

NAD+ Degrading Enzymes, Evidence for Roles During Infection

Tan, A., & Doig, C. L. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.697359 · Cited by 23

NAD + , Axonal Maintenance, and Neurological Disease

Alexandris, A. S., & Koliatsos, V. E. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0350 · Cited by 20

Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy

Kim, M., Kim, H., Kang, B.-G., Lee, J., Kim, T., Lee, H., Jung, J., Oh, M. J., Seo, S., Ryu, M., et al. (2023) · Theranostics · doi:10.7150/thno.85356 · Cited by 21

The copper-sensing transcription factor Mac1, the histone deacetylase Hst1, and nicotinic acid regulate de novo NAD+ biosynthesis in budding yeast

Raj, C. J. T., Croft, T., Venkatakrishnan, P., Groth, B., Dhugga, G., Cater, T., & Lin, S.-J. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006987 · Cited by 24

Scalable syntheses of traceable ribosylated NAD + precursors

Makarov, M. V., Harris, N. W., Rodrigues, M. D. S., & Migaud, M. E. (2019) · Organic & Biomolecular Chemistry · doi:10.1039/c9ob01981b · Cited by 20

Targeting NAD+: is it a common strategy to delay heart aging?

Yuan, Y., Liang, B., Liu, X., Liu, W., Huang, B., Yang, S., Gao, Y.-Z., Meng, J., Li, M., Ye, T., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01031-3 · Cited by 18

Bortezomib-induced neurotoxicity in human neurons is the consequence of nicotinamide adenine dinucleotide depletion

Snavely, A. R., Heo, K., Petrova, V., Ho, T. S., Huang, X., Hermawan, C., Kagan, R. D., Deng, T., Singeç, I., Chen, L., et al. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049358 · Cited by 19

The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products

Garb, J., Amitai, G., Lu, A., Ofir, G., Brandis, A. S., Mehlman, T., Kranzusch, P. J., & Sorek, R. (2024) · PLoS ONE · doi:10.1371/journal.pone.0302251 · Cited by 17

Therapeutic Significance of microRNA-Mediated Regulation of PARP-1 in SARS-CoV-2 Infection

Dash, S., Dash, C., & Pandhare, J. (2021) · Non-Coding RNA · doi:10.3390/ncrna7040060 · Cited by 17

Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model

Takaso, Y., Noda, M., Hattori, T., Roboon, J., Hatano, M., Sugimoto, H., Brenner, C., Yamamoto, Y., Okamoto, H., Higashida, H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-73984-3 · Cited by 17

Current and Emerging Pharmacotherapeutic Interventions for the Treatment of Peripheral Nerve Disorders

Chiang, J. C. B., Arnold, R., Dhanapalaratnam, R., Markoulli, M. P., & Krishnan, A. V. (2022) · Pharmaceuticals · doi:10.3390/ph15050607 · Cited by 16

SARM1 can be a potential therapeutic target for spinal cord injury

Lu, Q., Botchway, B. O. A., Zhang, Y., Jin, T., & Liu, X. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04195-4 · Cited by 16

Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons

Alexandris, A. S., Ryu, J., Rajbhandari, L., Harlan, R., McKenney, J., Wang, Y., Aja, S. M., Graham, D. R. M., Venkatesan, A., & Koliatsos, V. E. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105808 · Cited by 16

NAD+ metabolism in peripheral neuropathic pain

Dai, Y., Lin, J., Ren, J., Zhu, B., Wu, C., & Yu, L. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105435 · Cited by 15

A duplex structure of SARM1 octamers stabilized by a new inhibitor

Khazma, T., Golan-Vaishenker, Y., Guez-Haddad, J., Grossman, A., Sain, R., Weitman, M., Plotnikov, A. N., Zalk, R., Yaron, A., Hons, M., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04641-3 · Cited by 14

Die in pieces: How Drosophila sheds light on neurite degeneration and clearance

Sapar, M. L., & Han, C. (2019) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2019.03.010 · Cited by 12

Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications

Berry, D., Ene, J., Nathani, A., Singh, M. S., Li, Y., & Zeng, C. (2024) · Biomedicines · doi:10.3390/biomedicines12030489 · Cited by 14

SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low doses

Mani, A., Mendel, M., Westwood, P., Bonardi, C., Saal, W., Topp, A., Bilyard, M., Brigo, A., Wittwer, M., Benz, J., et al. (2025) · npj Drug Discovery. · doi:10.1038/s44386-025-00016-3 · Cited by 13

Cross-talk in NAD+ metabolism: insights from Saccharomyces cerevisiae

Raj, C. J. T., & Lin, S.-J. (2019) · Current Genetics · doi:10.1007/s00294-019-00972-0 · Cited by 13

Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway

Parsons, R. B., Kocinaj, A., Ruiz-Pulido, G., Prendergast, S. A., Parsons, A. E., Facey, P. D., & Hirth, F. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac077 · Cited by 13

Risks and rewards of targeting NAD+ homeostasis in the brain

Li, C., & Wu, L. E. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111545 · Cited by 14

Nicotinamide Adenine Dinucleotide (NAD + )-Dependent Signaling in Neurological Disorders

Bresque, M., Esteve, D., Pehar, M., & Vargas, M. R. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0241 · Cited by 13

SARM1 senses dsDNA to promote NAD+ degradation and cell death

Wang, L., Liu, Q., Li, S., Wang, N., Chen, Y., Chen, J., Wang, L., Huang, Y., Sun, Z., Dong, L., et al. (2025) · Cell · doi:10.1016/j.cell.2025.09.026 · Cited by 15

The histone deacetylases Rpd3 and Hst1 antagonistically regulate de novo NAD+ metabolism in the budding yeast Saccharomyces cerevisiae

Groth, B., Huang, C.-C., & Lin, S.-J. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102410 · Cited by 11

Harnessing lactic acid bacteria for nicotinamide mononucleotide biosynthesis: a review of strategies and future directions

Kong, L., Li, X., Liu, T., Yao, Q., & Qin, J. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1492179 · Cited by 10

Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications

Banerjee, P., Olmsted‐Davis, E. A., Deswal, A. M., Nguyen, M. T. H., Koutroumpakis, E., Palaskas, N., Lin, S. H., Kotla, S., Reyes‐Gibby, C. C., Yeung, S. J., et al. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.13 · Cited by 10

NAD in pathological cardiac remodeling: Metabolic regulation and beyond

Norambuena‐Soto, I., Deng, Y., Brenner, C., Lavandero, S., & Wang, Z. V. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167038 · Cited by 9

An updated review of YAP: A promising therapeutic target against cardiac aging?

Leng, J., Wang, C., Liang, Z., Qiu, F., Zhang, S., & Yuan, Y. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127670 · Cited by 11

The curious case of SARM1: Dr. Jekyll and Mr. Hyde in cell death and immunity?

Sarkar, A., Kumari, N., & Mukherjee, P. (2021) · FEBS Journal · doi:10.1111/febs.16256 · Cited by 9

Biotechnological production of reduced and oxidized NAD+ precursors

Perez, R. Z., García-Saura, A. G., Scantlebery, A. M. L., Schomakers, B. V., Rabadán-Ros, R., van Weeghel, M., Houtkooper, R. H., & Sánchez‐Ferrer, Á. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112560 · Cited by 7

Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans

Khazma, T., Grossman, A., Guez-Haddad, J., Feng, C., Dabas, H., Sain, R., Weitman, M., Zalk, R., Isupov, M. N., Hammarlund, M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113026 · Cited by 7

Nicotinamide Riboside Supplementation Alleviates Testicular Aging Induced by Disruption of Qprt‐Dependent NAD + De Novo Synthesis in Mice

Xu, Y., Wang, H., Li, H., Wei, C., Zhu, Z., Zhao, Y., Zhu, J., Lei, M., Sun, Y., & Yang, Q. (2025) · Aging Cell · doi:10.1111/acel.70004 · Cited by 8

Nicotinamide riboside–amino acid conjugates that are stable to purine nucleoside phosphorylase

Hayat, F., & Migaud, M. E. (2020) · Organic & Biomolecular Chemistry · doi:10.1039/d0ob00134a · Cited by 7

Randomized, placebo-controlled, pilot clinical study evaluating acute Niagen®+ IV and NAD+ IV in healthy adultsPreprint

Hawkins, J., Idoine, R., Kwon, J., Shao, A. E., Dunne, E., Hawkins, E. M., Dawson, K., & Nkrumah-Elie, Y. M. (2024) · medRxiv · doi:10.1101/2024.06.06.24308565 · Cited by 9

Molsidomine provides neuroprotection against vincristine-induced peripheral neurotoxicity through soluble guanylyl cyclase activation

Utkina-Sosunova, I. V., Chiorazzi, A., Planell-Saguer, M. D., Li, H., Meregalli, C., Pozzi, E., Carozzi, V., Canta, A., Monza, L., Alberti, P., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-70294-w · Cited by 6

Fat mobilization without weight loss is a potentially rapid response to nicotinamide riboside in obese people: it’s time to test with exercise

Fluharty, N. T., & Brenner, C. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa109 · Cited by 6

Quantitative Analysis of Daporinad (FK866) and Its In Vitro and In Vivo Metabolite Identification Using Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry

Park, M., Lee, B. I., Choi, J., Park, Y., Park, S., Lim, J.-H., Lee, J., & Shin, Y. G. (2022) · Molecules · doi:10.3390/molecules27062011 · Cited by 5

The Role of SIRT1 in Neuropathic Pain from the Viewpoint of Neuroimmunity

Fan, Y., Dong, R., Zhang, H., Yu, B., & Han, L. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210705162610 · Cited by 5

Why Is Mom Stressed: Homeorhesis as the Potential Problem and Nicotinamide Riboside as the Potential Solution

Brenner, C. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519869679 · Cited by 5

Nicotinamide Adenine Dinucleotide Precursor Supplementation Modulates Neurite Complexity and Survival in Motor Neurons from Amyotrophic Lateral Sclerosis Models

Hamilton, H. L., Akther, M., Anis, S., Colwell, C. B., Vargas, M. R., & Pehar, M. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0360 · Cited by 4

Development of a novel in vitro assay to screen for neuroprotective drugs against iatrogenic neurite shortening

Martínez, A. L., Brea, J. M., Barro, M., Monroy, X., Merlos, M., Burgueño, J., & Loza, M. I. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248139 · Cited by 4

Programmed neurite degeneration in human central nervous system neurons driven by changes in NAD+ metabolism

Brüll, M., Multrus, S., Schäfer, M., Celardo, I., Karreman, C., & Leist, M. (2025) · Cell Death and Disease · doi:10.1038/s41419-024-07326-w · Cited by 5

Brain aging-dependent glioma traits reversible by NAD + /BDNF-mediated neuronal reactivationPreprint

Yamashita, D., Flanary, V. L., Munk, R. B., Sonomura, K., Ozaki, S., Kawaguchi, R., Suehiro, S., Bastola, S., Pavlyukov, M. S., Yamaguchi, S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.10.334748 · Cited by 3

Integrated lipidomics and computational analyses reveal cardiolipin dysregulation as a therapeutic target in bortezomib-induced peripheral neuropathy

Tang, Y., Liu, J., & Gu, W. (2025) · Current Pharmaceutical Analysis · doi:10.1016/j.cpan.2025.02.002 · Cited by 2

Preventive Strategies for Chemotherapy-Induced Peripheral Neuropathy

Nielsen, S. W., & Herrstedt, J. (2021) · Springer eBooks · doi:10.1007/978-3-030-78663-2_4 · Cited by 2

A senescent metabolism-modulating hierarchical scaffold restores NAD+ homeostasis and redox balance for aged bone repair

Jiang, J., Chen, J., Wang, X., Zhang, X., Lv, H., Wu, C., Han, L., & Zhu, Y. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.06.036 · Cited by 1

Phagocytosis and self-destruction execute dendrite degeneration of Drosophila sensory neurons at distinct levels of NAD+ reductionPreprint

Ji, H., Sapar, M. L., Sarkar, A., Wang, B., & Han, C. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.26.173245 · Cited by 1

A Duplex Structure of SARM1 Octamers Induced by a New InhibitorPreprint

Khazma, T., Golan-Vaishenker, Y., Guez-Haddad, J., Grossman, A., Sain, R., Plotnikov, A. N., Zalk, R., Yaron, A., Hons, M., & Opatowsky, Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.02.482641 · Cited by 1

SLC25A51 impacts drug sensitivity in AML cells by sustaining mitochondrial oxidative fluxPreprint

Lu, M., Busquets, J., Impedovo, V., Chang, Y.-T., Matsui, W. H., Tiziani, S., & Cambronne, X. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.15.516643 · Cited by 1

Assessing cellular senescence, NAD+ and ageing in chemotherapy related side-effects in colorectal cancer survivors

Wu, W. (2024) · Research Publications (Maastricht University) · doi:10.26481/dis.20240628ww

Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program

Geisler, S., Doan, R. A., Cheng, G., Cetinkaya‐Fisgin, A., Huang, S. X., Höke, A., Milbrandt, J., & DiAntonio, A. (2019) · JCI Insight · doi:10.1172/jci.insight.129920 · Cited by 146

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

Di Stefano, M., Nascimento-Ferreira, I., Orsomando, G., Mori, V, Gilley, J., Brown, R., Janeckova, L., Vargas, M. E., Worrell, L. A., Loreto, A., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.164 · Cited by 246

Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy

Sasaki, Y., Araki, T., & Milbrandt, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2320-06.2006 · Cited by 269

Nicotinamide adenine dinucleotide prevents axonal degeneration.

Qi, X., Li, Z., Zhang, J., Liu, W., Lü, J., Peng, F., Yang, J., & Sun, J. (2009) · Journal of Shandong University

Exploring clinical markers of Axon degeneration processes in Chemotherapy-induced peripheral neuropathy among young adults receiving vincristine or paclitaxel

Knoerl, R., Mazzola, E., Pazyra‐Murphy, M. F., Ryback, B. A., Frazier, A. L., Freeman, R. L., Hammer, M. J., LaCasce, A. S., Ligibel, J. A., Luskin, M. R., et al. (2024) · BMC Neurology · doi:10.1186/s12883-024-03877-9 · Cited by 8