The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Intestinal barrier dysfunction orchestrates the onset of inflammatory host–microbiome cross-talk in a human gut inflammation-on-a-chip
Open accessAbstract
Significance: Identification of the trigger of human intestinal inflammation can be a compelling clinical strategy for developing effective and target-specific antiinflammatory therapeutics. The pathomimetic “gut inflammation-on-a-chip” inspired by dextran sodium sulfate (DSS)-induced colitis models in mice enabled the independent uncoupling of complex inflammatory cross-talks and the combinatorial recoupling of individual contributing factors one at a time to identify the initiator of inflammatory responses. Our discovery suggests that an intact epithelial barrier is necessary to maintain the “homeostatic tolerance” in response to physiological host–gut microbiome cross-talks. We also expound an insight of probiotic therapy that the undamaged epithelial barrier is a prerequisite for eliciting the probiotic efficacy. Finally, the gut inflammation-on-a-chip verifies how microphysiological systems can be successfully implemented to dissect the mechanisms of gastrointestinal diseases.
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Cited by
A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip
Jalili-Firoozinezhad, S., Gazzaniga, F. S., Calamari, E. L., Camacho, D. M., Fadel, C. W., Bein, A., Swenor, B., Nestor, B., Cronce, M. J., Tovaglieri, A., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0397-0 · Cited by 855
Elinav, E., Garrett, W. S., Trinchieri, G., & Wargo, J. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0155-3 · Cited by 215
Shin, W., Hinojosa, C. D., Ingber, D. E., & Kim, H. J. (2019) · iScience · doi:10.1016/j.isci.2019.04.037 · Cited by 186
Self-citationFowler, S., Chen, W. L. K., Duignan, D. B., Gupta, A., Hariparsad, N., Kenny, J. R., Lai, W. G., Liras, J., Phillips, J. A., & Gan, J. (2020) · Lab on a Chip · doi:10.1039/c9lc00857h · Cited by 109
Intestinal organoids: A new paradigm for engineering intestinal epithelium in vitro
Rahmani, S., Breyner, N. M., Su, H.-M., Verdu, E. F., & Didar, T. F. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.12.006 · Cited by 98
Metadata
- Authors
- Shin, W., & Kim, H. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-10-22
- Volume
- 115
- Issue
- 45
- Pages
- E10539-E10547
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2897044614
- Cited by
- 309
- References
- 65
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Shin, W., & Kim, H. J. (2018). Intestinal barrier dysfunction orchestrates the onset of inflammatory host–microbiome cross-talk in a human gut inflammation-on-a-chip. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1810819115
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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