The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
Open accessAbstract
Significance: PIEZOs are mechanically activated cation channels. Recently, loss-of-function mutations of human PIEZO1 were found among patients with familial lymphedema, suggesting a requirement of PIEZO1 in the lymphatic system. In this paper, utilizing mouse models lacking PIEZO1 in endothelial cells, we show that this ion channel is required for the formation of lymphatic valves, a key structure for proper circulation of lymph in the body. The requirement of PIEZO1 in valve formation provides mechanistic insight on how PIEZO1 variants cause lymphatic dysfunction in patients. This study also extends the relevance of PIEZOs beyond acute signaling molecules (e.g., touch sensation) and highlights the importance of these ion channels in controlling morphological/structural specification during development.
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Cites
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Structure of the mechanically activated ion channel Piezo1
Saotome, K., Murthy, S. E., Kefauver, J. M., Whitwam, T., Patapoutian, A., & Ward, A. B. (2018) · Nature · doi:10.1038/nature25453 · Cited by 649
Self-citationStructure and mechanogating mechanism of the Piezo1 channel
Zhao, Q., Zhou, H., Chi, S., Wang, Y., Wang, J., Geng, J., Wu, K., Liu, W., Zhang, T., Dong, M.-Q., et al. (2018) · Nature · doi:10.1038/nature25743 · Cited by 628
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release
Wang, S., Chennupati, R., Kaur, H., Iring, A., Wettschureck, N., & Offermanns, S. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87343 · Cited by 616
The Role of PIEZO2 in Human Mechanosensation
Chesler, A. T., Szczot, M., Bharucha-Goebel, D., Čeko, M., Donkervoort, S., Laubacher, C., Hayes, L. H., Alter, K., Zampieri, C., Stanley, C., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1602812 · Cited by 462
Sabine, A., Agalarov, Y., Maby-El Hajjami, H., Jaquet, M., Hägerling, R., Pollmann, C., Bebber, D., Pfenniger, A., Miura, N., Dormond, O., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.020 · Cited by 411
Rode, B., Shi, J., Endesh, N., Drinkhill, M. J., Webster, P. J., Lotteau, S. J., Bailey, M. A., Yuldasheva, N. Y., Ludlow, M. J., Cubbon, R. M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00429-3 · Cited by 305
Notch signaling functions in lymphatic valve formation
Murtomaki, A., Uh, M. K., Kitajewski, C., Zhao, J., Nagasaki, T., Shawber, C. J., & Kitajewski, J. (2014) · Development · doi:10.1242/dev.101188 · Cited by 55
Cited by
Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
Atcha, H., Jairaman, A., Holt, J. R., Meli, V. S., Nagalla, R. R., Veerasubramanian, P. K., Brumm, K. T., Lim, H. E., Othy, S., Cahalan, M. D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23482-5 · Cited by 644
Mechanical regulation of bone remodeling
Wang, L., You, X., Zhang, L., Zhang, C., & Zou, W. (2022) · Bone Research · doi:10.1038/s41413-022-00190-4 · Cited by 641
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
Mechanical stiffness controls dendritic cell metabolism and function
Chakraborty, M., Chu, K., Shrestha, A., Revelo, X. S., Zhang, X., Gold, M. J., Khan, S., Lee, M., Huang, C., Akbari, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108609 · Cited by 258
Force Sensing by Piezo Channels in Cardiovascular Health and Disease
Beech, D. J., & Kalli, A. C. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.313348 · Cited by 242
Metadata
- Authors
- Nonomura, K., Lukacs, V., Sweet, D. T., Goddard, L. M., Kanie, A., Whitwam, T., Ranade, S. S., Fujimori, T., Kahn, M. L., & Patapoutian, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-11-27
- Volume
- 115
- Issue
- 50
- Pages
- 12817-12822
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2903035331
- Cited by
- 267
- References
- 8
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
