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Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
Open accessAbstract
Significance: PIEZOs are mechanically activated cation channels. Recently, loss-of-function mutations of human PIEZO1 were found among patients with familial lymphedema, suggesting a requirement of PIEZO1 in the lymphatic system. In this paper, utilizing mouse models lacking PIEZO1 in endothelial cells, we show that this ion channel is required for the formation of lymphatic valves, a key structure for proper circulation of lymph in the body. The requirement of PIEZO1 in valve formation provides mechanistic insight on how PIEZO1 variants cause lymphatic dysfunction in patients. This study also extends the relevance of PIEZOs beyond acute signaling molecules (e.g., touch sensation) and highlights the importance of these ion channels in controlling morphological/structural specification during development.
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Structural and thermodynamic framework for PIEZO1 modulation by small molecules
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Endothelial force sensing signals to parenchymal cells to regulate bile and plasma lipids
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Metadata
- Authors
- Nonomura, K., Lukacs, V., Sweet, D. T., Goddard, L. M., Kanie, A., Whitwam, T., Ranade, S. S., Fujimori, T., Kahn, M. L., & Patapoutian, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-11-27
- Volume
- 115
- Issue
- 50
- Pages
- 12817-12822
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2903035331
- Cited by
- 267
- References
- 8
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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