The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1
Open accessAbstract
Significance: Endoplasmic reticulum (ER) and mitochondria form close associations that serve as a critical signaling platform. Loss-of-function mutations in DJ-1 are associated with autosomal recessive early onset Parkinson’s disease (PD). We found that DJ-1 knockout caused significant impairments in the structure and function of ER-mitochondria association in neuronal cells and in vivo. Reduced DJ-1 was associated with deficits in ER-mitochondria association in the substantia nigra of sporadic PD. Our study identifies DJ-1 as a critical component of the macrocomplex containing IP3R3-Grp75-VDAC1 at mitochondria-associated membrane and as playing an important role in the regulation of the integrity and function of ER-mitochondria association. Our research offers insights into the regulation mechanism of ER-mitochondria association and the pathogenic mechanism of DJ-1 deficiency in PD.
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Cited by
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Metadata
- Authors
- Liu, Y., Ma, X., Fujioka, H., Liu, J., Chen, S., & Zhu, X.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2019-11-25
- Volume
- 116
- Issue
- 50
- Pages
- 25322-25328
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2990547772
- Cited by
- 294
- References
- 42
- FWCI
- 14.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liu, Y., Ma, X., Fujioka, H., Liu, J., Chen, S., & Zhu, X. (2019). DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1906565116
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