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Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes

Bhattacharyya, Raja, Black, Sophia E., Lotlikar, Madhura S., Fenn, Rebecca H., Jorfi, Mehdi, Kovacs, Dora M., Tanzi, Rudolph E.·2021·Cell Reports
DOI 10.1016/j.celrep.2021.109134PMC PMC8287518
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Crossref · 10.1016/j.celrep.2021.109134

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  • The APP processing pathway is highly regulated by mobilization of cholesterol between lipid rafts and the plasma membrane.

    “The APP processing pathway is highly regulated by the mobilization of cholesterol between the lipid rafts and PM [41, 42].”

    From Inhibition of ACAT as a Therapeutic Target for Alzheimer's Disease Is Independent of ApoE4 Lipidation (2023) · cites this paper as [41]

    The Discussion (page not provided) reports that changes in MAM assembly alter palmitoylated APP trafficking, β-secretase cleavage, and Aβ generation, supporting regulation of APP processing. It does not show that mobilization of cholesterol between lipid rafts and the plasma membrane is the regulating mechanism. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • APP is palmitoylated at the ER for mobilization to the PM lipid rafts to be processed by γ and β secretases.

    “APP is palmitoylated at the ER for mobilization to the PM lipid rafts to be processed by γ and β secretases [41].”

    From Inhibition of ACAT as a Therapeutic Target for Alzheimer's Disease Is Independent of ApoE4 Lipidation (2023) · cites this paper as [41]

    The Introduction says APP is palmitoylated in the ER before localizing to lipid rafts, where it is preferentially cleaved by β-secretase. The Discussion also reports cell-surface trafficking of palmitoylated APP, but emphasizes that most is localized to mitochondria-associated ER membranes (MAMs). The paper does not establish that APP is mobilized to plasma-membrane lipid rafts to be processed there by both β- and γ-secretases. Page numbers are unavailable in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Metadata

Authors
Bhattacharyya, R., Black, S. E., Lotlikar, M. S., Fenn, R. H., Jorfi, M., Kovacs, D. M., & Tanzi, R. E.
ORCID
Fenn, Rebecca H.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2021-05
Volume
35
Issue
7
Pages
109134
ISSN
2211-1247
DOI
10.1016/j.celrep.2021.109134
PMC
PMC8287518
Cited by
77
References
10
Language
en
Licence
Funders
NIH

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