The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Myosin VI is a processive motor with a large step size
Open accessAbstract
Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. To carry out its cellular functions myosin VI moves toward the pointed end of actin, backward in relation to all other characterized myosins. Myosin V, a motor that moves toward the barbed end of actin, is processive, undergoing multiple catalytic cycles and mechanical advances before it releases from actin. Here we show that myosin VI is also processive by using single molecule motility and optical trapping experiments. Remarkably, myosin VI takes much larger steps than expected, based on a simple lever-arm mechanism, for a myosin with only one light chain in the lever-arm domain. Unlike other characterized myosins, myosin VI stepping is highly irregular with a broad distribution of step sizes.
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Cites
Single myosin molecule mechanics: piconewton forces and nanometre steps
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Self-citationBead movement by single kinesin molecules studied with optical tweezers
Block, S. M., Goldstein, L. S. B., & Schnapp, B. J. (1990) · Nature · doi:10.1038/348348a0 · Cited by 1,038
Reversible Unfolding of Single RNA Molecules by Mechanical Force
Liphardt, J., Onoa, B., Smith, S. B., Tinoco, I., & Bustamante, C. (2001) · Science · doi:10.1126/science.1058498 · Cited by 931
Movement of microtubules by single kinesin molecules
Howard, J., Hudspeth, A. J., & Vale, R. D. (1989) · Nature · doi:10.1038/342154a0 · Cited by 885
Myosin-V is a processive actin-based motor
Mehta, A. D., Rock, R. S., Rief, M., Spudich, J. A., Mooseker, M. S., & Cheney, R. E. (1999) · Nature · doi:10.1038/23072 · Cited by 786
Self-citationMyosin VI is an actin-based motor that moves backwards
Wells, A. L., Lin, A. W., Chen, L.-Q., Safer, D., Cain, S. M., Hasson, T., Carragher, B. O., Milligan, R. A., & Sweeney, H. L. (1999) · Nature · doi:10.1038/46835 · Cited by 681
Self-citationA single myosin head moves along an actin filament with regular steps of 5.3 nanometres
Kitamura, K., Tokunaga, M., Iwane, A. H., & Yanagida, T. (1999) · Nature · doi:10.1038/16403 · Cited by 530
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Molecular motors: structural adaptations to cellular functions
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Myosin-V stepping kinetics: A molecular model for processivity
Rief, M., Rock, R. S., Mehta, A. D., Mooseker, M. S., Cheney, R. E., & Spudich, J. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.17.9482 · Cited by 402
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Cited by
High-Resolution, Single-Molecule Measurements of Biomolecular Motion
Greenleaf, W. J., Woodside, M. T., & Block, S. M. (2007) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.36.101106.101451 · Cited by 462
Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis
Sahlender, D. A., Roberts, R. C., Arden, S. D., Spudich, G., Taylor, M. J., Luzio, J. P., Kendrick-Jones, J., & Buss, F. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200501162 · Cited by 426
Force-Induced Bidirectional Stepping of Cytoplasmic Dynein
Gennerich, A., Carter, A. P., Reck-Peterson, S. L., & Vale, R. D. (2007) · Cell · doi:10.1016/j.cell.2007.10.016 · Cited by 381
Intramolecular Strain Coordinates Kinesin Stepping Behavior along Microtubules
Yildiz, A., Tomishige, M., Gennerich, A., & Vale, R. D. (2008) · Cell · doi:10.1016/j.cell.2008.07.018 · Cited by 313
Functional diversity among a family of human skeletal muscle myosin motors
Resnicow, D. I., Deacon, J. C., Warrick, H. M., Spudich, J. A., & Leinwand, L. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913527107 · Cited by 116
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Metadata
- Authors
- Rock, R. S., Rice, S. E., Wells, A. L., Purcell, T. J., Spudich, J. A., & Sweeney, H. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-11-13
- Volume
- 98
- Issue
- 24
- Pages
- 13655-13659
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2055027542
- Cited by
- 377
- References
- 29
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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