Sexually dimorphic role of oxytocin in medaka mate choice
Open accessAbstract
Oxytocin is a central neuromodulator required for facilitating mate preferences for familiar individuals in a monogamous rodent (prairie vole), irrespective of sex. While the role of oxytocin in mate choice is only understood in a few monogamous species, its function in nonmonogamous species, comprising the vast majority of vertebrate species, remains unclear. To address this issue, we evaluated the involvement of an oxytocin homolog (isotocin, referred herein as oxt) in mate choice in medaka fish ( Oryzias latipes ). Female medaka prefer to choose familiar mates, whereas male medaka court indiscriminately, irrespective of familiarity. We generated mutants of the oxt ligand ( oxt ) and receptor genes ( oxtr1 and oxtr2 ) and revealed that the oxt-oxtr1 signaling pathway was essential for eliciting female mate preference for familiar males. This pathway was also required for unrestricted and indiscriminate mating strategy in males. That is, either oxt or oxtr1 mutation in males decreased the number of courtship displays toward novel females, but not toward familiar females. Further, males with these mutations exhibited enhanced mate-guarding behaviors toward familiar females, but not toward novel females. In addition, RNA-sequencing (seq) analysis revealed that the transcription of genes involved in gamma-amino butyric acid metabolism as well as those encoding ion-transport ATPase are up-regulated in both oxt and oxtr1 mutants only in female medaka, potentially explaining the sex difference of the mutant phenotype. Our findings provide genetic evidence that oxt-oxtr1 signaling plays a role in the mate choice for familiar individuals in a sex-specific manner in medaka fish.
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Mutating oxytocin receptors using CRISPR reduces mating preference in female medaka and results in the emergence of preference for familiar females in males.
“However, mutating oxytocin receptors using CRISPR reduces mating preference in females and results in the emergence of preference for familiar females in males (Yokoi et al. 2020).”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Yokoi et al. 2020
The Results report that oxtr1 mutation removes females’ preference for familiar males and produces a preference for familiar females in males. But the Results section on mutant generation says oxtr1 mutants were made using TALEN, not CRISPR/Cas9; the receptor mutated with CRISPR/Cas9 was oxtr2. The claim gets the behavioral findings right but attributes them to the wrong editing method. (LLM, conf=0.92)
Experimental — accuracy not yet measuredOxytocin mediates mating preferences in polygamous species.
“Oxytocin also mediates mating preferences in polygamous species.”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Yokoi et al. 2020
Females with targeted Oxt or Oxtr mutations lose preference for familiar males and mate indiscriminately, while Oxt or Oxtr mutant males preferentially mate with familiar females.
“Females with targeted Oxt or Oxtr mutations lose preference for familiar males and mate indiscriminately, while Oxt or Oxtr mutant males preferentially mate with familiar females.”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [28]
Thus, OXTR signaling promotes the adaptive mate preference of particular species, which in promiscuous species may be sexually dimorphic.
“Thus, OXTR signaling promotes the adaptive mate preference of particular species, which in promiscuous species may be sexually dimorphic (28).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [28]
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Cites
Guide for the Care and Use of Laboratory Animals: Eighth Edition
(2011) · doi:10.17226/12910 · Cited by 16,199 · see citing works
Sexual Selection and the Descent of Man
(2017) · Routledge eBooks · doi:10.4324/9781315129266 · Cited by 7,284 · see citing works
Parental Investment and Sexual Selection
Campbell, B. (2017) · doi:10.4324/9781315129266-7 · Cited by 1,051 · see citing works
The biology of mammalian parenting and its effect on offspring social development
Rilling, J. K., & Young, L. J. (2014) · Science · doi:10.1126/science.1252723 · Cited by 452 · see citing works
Self-citationNuman, M., & Young, L. J. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.015 · Cited by 355 · see citing works
Self-citationThe neural mechanisms and circuitry of the pair bond
Walum, H., & Young, L. J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0072-6 · Cited by 353 · see citing works
Self-citationExtracellular matrix and the brain: components and function
Novak, U., & Kaye, A. H. (2000) · Journal of Clinical Neuroscience · doi:10.1054/jocn.1999.0212 · Cited by 279 · see citing works
The prairie vole: An emerging model organism for understanding the social brain
McGraw, L. A., & Young, L. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.006 · Cited by 276 · see citing works
Self-citationFamiliarity leads to female mate preference for novel males in the guppy, Poecilia reticulata
Hughes, K. A., DU, L., Rodd, F. H., & Reznick, D. N. (1999) · Animal Behaviour · doi:10.1006/anbe.1999.1225 · Cited by 271 · see citing works
Song, Z., & Albers, H. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.004 · Cited by 244 · see citing works
Hormonal and pheromonal control of spawning behavior in the goldfish
Kobayashi, M., Sorensen, P. W., & Stacey, N. E. (2002) · Fish Physiology and Biochemistry · doi:10.1023/a:1023375931734 · Cited by 236 · see citing works
Targeted mutagenesis using CRISPR/Cas system in medaka
Ansai, S., & Kinoshita, M. (2014) · Biology Open · doi:10.1242/bio.20148177 · Cited by 222 · see citing works
Self-citationJohnson, Z. V., Walum, H., Jamal, Y. A., Xiao, Y., Keebaugh, A. C., Inoue, K., & Young, L. J. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.11.011 · Cited by 190 · see citing works
Self-citationA Neural Mechanism Underlying Mating Preferences for Familiar Individuals in Medaka Fish
Okuyama, T., Yokoi, S., Abe, H., Isoe, Y., Suehiro, Y., Imada, H., Tanaka, M., Kawasaki, T., Yuba, S., Taniguchi, Y., et al. (2014) · Science · doi:10.1126/science.1244724 · Cited by 180 · see citing works
Self-citationGeneration of medaka gene knockout models by target-selected mutagenesis
Taniguchi, Y., Takeda, S., Furutani‐Seiki, M., Kamei, Y., Todo, T., Sasado, T., Deguchi, T., Kondoh, H., Mudde, J., Yamazoe, M., et al. (2006) · Genome biology · doi:10.1186/gb-2006-7-12-r116 · Cited by 149 · see citing works
Self-citationBull, C. M. (2000) · Behavioural Processes · doi:10.1016/s0376-6357(00)00115-7 · Cited by 148 · see citing works
Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior
Yabuki, Y., Koide, T., Miyasaka, N., Wakisaka, N., Masuda, M., Ohkura, M., Nakai, J., Tsuge, K., Tsuchiya, S., Sugimoto, Y., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4314 · Cited by 148 · see citing works
Oxytocin-like receptors mediate pair bonding in a socially monogamous songbird
Klatt, J. D., & Goodson, J. L. (2012) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2012.2396 · Cited by 132 · see citing works
Paciorkowski, A. R., McDaniel, S. S., Jansen, L. A., Tully, H. M., Tuttle, E. T., Ghoneim, D. H., Tupal, S., Gunter, S. A., Vasta, V., Zhang, Q., et al. (2015) · Epilepsia · doi:10.1111/epi.12914 · Cited by 122 · see citing works
Neuropeptide regulation of social behavior in a monogamous cichlid fish
Oldfield, R. G., & Hofmann, H. A. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.11.022 · Cited by 118 · see citing works
Ansai, S., Sakuma, T., Yamamoto, T., Ariga, H., Uemura, N., Takahashi, R., & Kinoshita, M. (2013) · Genetics · doi:10.1534/genetics.112.147645 · Cited by 115 · see citing works
Self-citationYokoi, S., Okuyama, T., Kamei, Y., Naruse, K., Taniguchi, Y., Ansai, S., Kinoshita, M., Young, L. J., Takemori, N., Kubo, T., et al. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005009 · Cited by 95 · see citing works
Self-citationIndividual Recognition in a Cooperatively Breeding Cichlid: Evidence from Video Playback Experiments
Balshine, S., & Lotem, A. (1998) · Behaviour · doi:10.1163/156853998793066221 · Cited by 73 · see citing works
Individual recognition and the ‘face inversion effect’ in medaka fish (Oryzias latipes)
Wang, M.-Y., & Takeuchi, H. (2017) · eLife · doi:10.7554/elife.24728 · Cited by 72 · see citing works
Self-citationHuffman, L. S., O’Connell, L. A., Kenkel, C. D., Kline, R. J., Khan, I. A., & Hofmann, H. A. (2012) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2012.05.002 · Cited by 71 · see citing works
Individual and species recognition in centrarchid fishes: evidence and hypotheses
Brown, J. A., & Colgan, P. W. (1986) · Behavioral Ecology and Sociobiology · doi:10.1007/bf00295711 · Cited by 66 · see citing works
Kawabata, Y., Hiraki‐Kajiyama, T., Takeuchi, A., & Okubo, K. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.021 · Cited by 65 · see citing works
High-resolution melting curve analysis for rapid detection of mutations in a Medaka TILLING library
Ishikawa, T., Kamei, Y., Otozai, S., Kim, J., Sato, A., Kuwahara, Y., Tanaka, M., Deguchi, T., Inohara, H., Tsujimura, T., et al. (2010) · BMC Molecular Biology · doi:10.1186/1471-2199-11-70 · Cited by 63 · see citing works
Self-citationKin recognition and choice of shoal mates by threespine sticklebacks
FitzGerald, G. J., & Morrissette, J. (1992) · Ethology Ecology & Evolution · doi:10.1080/08927014.1992.9523138 · Cited by 57 · see citing works
Yokoi, S., Ansai, S., Kinoshita, M., Naruse, K., Kamei, Y., Young, L. J., Okuyama, T., & Takeuchi, H. (2016) · Frontiers in Zoology · doi:10.1186/s12983-016-0152-2 · Cited by 49 · see citing works
Self-citationThe Effect of Familiarity on Mate Choice
Cheetham, S. A., Thom, M. D. F., Beynon, R. J., & Hurst, J. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-73945-8_26 · Cited by 42 · see citing works
Kang, E., Song, J., Lin, Y.-T., Park, J., Lee, J. H., Hussani, Q., Gu, Y., Ge, S., Li, W., Hsu, K., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.024 · Cited by 34 · see citing works
O’Connor, C. M., Marsh‐Rollo, S. E., Ghio, S. C., Balshine, S., & Aubin‐Horth, N. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.07.008 · Cited by 32 · see citing works
Isoe, Y., Konagaya, Y., Yokoi, S., Kubo, T., & Takeuchi, H. (2016) · ZOOLOGICAL SCIENCE · doi:10.2108/zs150213 · Cited by 16 · see citing works
Self-citationA Role for Oxytocin-Like Receptor in Social Habituation in a Teleost
Weitekamp, C. A., Solomon‐Lane, T. K., Valle, P. D., Triki, Z., Nugent, B. M., & Hofmann, H. A. (2017) · Brain Behavior and Evolution · doi:10.1159/000464098 · Cited by 15 · see citing works
WALTER, R., Smith, C. W. J., & Roy, J. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.9.3054 · Cited by 13 · see citing works
C1q as a Regulator of Brain Development: Implications for Autism Spectrum Disorders
Tan, C. F. J. (2015) · Brain Disorders & Therapy · doi:10.4172/2168-975x.1000152 · Cited by 9 · see citing works
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- [22]Yokoi S., Mito M., Iwasaki S., Nakagawa S., Takeuchi H., The gene expression of the brain/pituitary from oxt/oxtr1 homozygous mutants and WT medaka in both sexes. GEO. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE139158. Deposited 21 October 2019.
- [25]Wang M. Y., Takeuchi H.. Individual recognition and the ‘face inversion effect’ in medaka fish (Oryzias latipes). elife 6, e24728 (2017). [DOI] [PMC free article] [PubMed] [Google Scholar]
Cited by
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Oxytocin, Neural Plasticity, and Social Behavior
Froemke, R. C., & Young, L. J. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-102320-102847 · Cited by 487 · see citing works
Self-citationOxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities
Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac111 · Cited by 191 · see citing works
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Padilla, L. F. A., Castañeda-Cortés, D. C., da Rosa, I. F., Acosta, O. D. M., Hattori, R. S., Nóbrega, R. H., & Fernandino, J. I. (2021) · eLife · doi:10.7554/elife.62757 · Cited by 13 · see citing works
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Jackson, L. R., Lopez, M. S., & Alward, B. A. (2023) · Integrative and Comparative Biology · doi:10.1093/icb/icad068 · Cited by 8 · see citing works
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Kondo, Y., Okamoto, K., Kitamukai, Y., Koya, Y., & Awata, S. (2025) · PLoS ONE · doi:10.1371/journal.pone.0318358 · Cited by 7 · see citing works
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Self-citationKayo, D., Kimura, S., Yamazaki, T., Naruse, K., Takeuchi, H., & Ansai, S. (2023) · genesis · doi:10.1002/dvg.23519 · Cited by 7 · see citing works
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Self-citationKondo, Y., Kobayashi, R., Kobayashi, Y., & Awata, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-11082-y · Cited by 2 · see citing works
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Self-citationMeng, Q., Watanabe, Y., Tatsukawa, H., Hashimoto, H., & Hitomi, K. (2022) · The Journal of Biochemistry · doi:10.1093/jb/mvac065 · Cited by 1 · see citing works
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Self-citationLemaire, F. (1990) · OpenGrey (Institut de l'Information Scientifique et Technique)
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Yokoi, S., Mochizuki-Koike, R., Yamashiro, K., Nakagawa, S., Ikegaya, Y., & Matsumoto, N. (2026) · Scientific Reports · doi:10.1038/s41598-026-51830-2
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Fujimoto, S., Myosho, T., Kobayashi, H., Aoyama, H., Murase, I., Sumarto, B. K. A., Yagi, M., Kunishima, T., Matsunami, M., & Kimura, R. (2026) · Ecology and Evolution · doi:10.1002/ece3.74383
Yokoi, S., & Takeuchi, H. (2026) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2026.115035
Self-citation
- Authors
- Yokoi, S., Naruse, K., Kamei, Y., Ansai, S., Kinoshita, M., Mito, M., Iwasaki, S., Inoue, S., Okuyama, T., Nakagawa, S., Young, L. J., & Takeuchi, H.
- Affiliations
- National Institute for Basic Biology (JP)
- Kyoto University (JP)
- RIKEN (JP)
- Hokkaido University (JP)
- Institute for Quantitative Biosciences, The University of Tokyo (JP)
- University of Tsukuba (JP)
- Okayama University (JP)
- Corresponding author
- Yokoi, Saori
- Takeuchi, Hideaki
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2020-02-18
- Volume
- 117
- Issue
- 9
- Pages
- 4802-4808
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC7060708
- OpenAlex
- W3007375964
- Cited by
- 62
- References
- 37
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 8 · 2023: 12 · 2022: 8 · 2021: 8 · 2020: 7
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- MEXT | NINS | National Institute for Basic Biology (10-104, 19-347)
- MEXT | National Institutes of Natural Sciences (#01111904)
- MEXT | Japan Society for the Promotion of Science (16K18369, 19K16247, 16H06524, 18H02479, 16H01276, Grant-in-Aid for JSPS fellows)
- Sumitomo Foundation (180597)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- oxytocin, isotocin, mate choice, medaka, sex differences, courtship behavior, mate guarding, familiarity, GABA metabolism, social behavior genetics
- MeSH terms
- Animals, Courtship, Female, Male, Mutation, Oryzias, Oxytocin, Phenotype, Reproduction, Sexual Behavior, Animal, Sex Characteristics, Receptors, Oxytocin, Recognition, Psychology, Mating Preference, Animal
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