The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Calcification in atherosclerosis: Bone biology and chronic inflammation at the arterial crossroads
Open accessAbstract
Dystrophic or ectopic mineral deposition occurs in many pathologic conditions, including atherosclerosis. Calcium mineral deposits that frequently accompany atherosclerosis are readily quantifiable radiographically, serve as a surrogate marker for the disease, and predict a higher risk of myocardial infarction and death. Accelerating research interest has been propelled by a clear need to understand how plaque structure, composition, and stability lead to devastating cardiovascular events. In atherosclerotic plaque, accumulating evidence is consistent with the notion that calcification involves the participation of arterial osteoblasts and osteoclasts. Here we summarize current models of intimal arterial plaque calcification and highlight intriguing questions that require further investigation. Because atherosclerosis is a chronic vascular inflammation, we propose that arterial plaque calcification is best conceptualized as a convergence of bone biology with vascular inflammatory pathobiology.
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Cites
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Cited by
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Vascular Actions of Estrogens: Functional Implications
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Vascular Calcification—New Insights into Its Mechanism
Lee, S. J., Lee, I.-K., & Jeon, J.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082685 · Cited by 438
Aortic Valve Stenosis: From Basic Mechanisms to Novel Therapeutic Targets
Goody, P. R., Hosen, M. R., Christmann, D., Niepmann, S. T., Zietzer, A., Adam, M., Bönner, F., Zimmer, S., Nickenig, G., & Jansen, F. (2020) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.313067 · Cited by 331
Metadata
- Authors
- Doherty, T. M., Asotra, K., Fitzpatrick, L. A., Qiao, J.-H., Wilkin, D. J., Detrano, R. C., Dunstan, C. R., Shah, P. K., & Rajavashisth, T. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-09-19
- Volume
- 100
- Issue
- 20
- Pages
- 11201-11206
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2114721006
- Cited by
- 458
- References
- 52
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Doherty, T. M., Asotra, K., Fitzpatrick, L. A., Qiao, J.-H., Wilkin, D. J., Detrano, R. C., Dunstan, C. R., Shah, P. K., & Rajavashisth, T. B. (2003). Calcification in atherosclerosis: Bone biology and chronic inflammation at the arterial crossroads. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1932554100
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