The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.
Aortic Valve Stenosis: From Basic Mechanisms to Novel Therapeutic Targets
Open accessAbstract
Aortic valve stenosis is the most prevalent heart valve disease worldwide. Although interventional treatment options have rapidly improved in recent years, symptomatic aortic valve stenosis is still associated with high morbidity and mortality. Calcific aortic valve stenosis is characterized by a progressive fibro-calcific remodeling and thickening of the aortic valve cusps, which subsequently leads to valve obstruction. The underlying pathophysiology is complex and involves endothelial dysfunction, immune cell infiltration, myofibroblastic and osteoblastic differentiation, and, subsequently, calcification. To date, no pharmacotherapy has been established to prevent aortic valve calcification. However, novel promising therapeutic targets have been recently identified. This review summarizes the current knowledge of pathomechanisms involved in aortic valve calcification and points out novel treatment strategies.
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Cites
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Cited by
Lumican promotes calcific aortic valve disease through H3 histone lactylation
Huang, Y., Wang, C., Zhou, T., Xie, F., Liu, Z., Xu, H., Liu, M., Wang, S., Li, L., Chi, Q., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae407 · Cited by 124
Calcific Aortic Stenosis: A Review
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Lyu, T., Liu, Y., Li, B., Xu, R., Guo, J., & Zhu, D. (2023) · Biology Direct · doi:10.1186/s13062-023-00390-w · Cited by 18
Mueller, K. A. L., Langnau, C., Harm, T., Sigle, M., Mott, K., Droppa, M., Borst, O., Rohlfing, A.-K., Gekeler, S., Günter, M., et al. (2024) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.124.321000 · Cited by 7
Metadata
- Authors
- Goody, P. R., Hosen, M. R., Christmann, D., Niepmann, S. T., Zietzer, A., Adam, M., Bönner, F., Zimmer, S., Nickenig, G., & Jansen, F.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2020-04
- Volume
- 40
- Issue
- 4
- Pages
- 885-900
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W3012454946
- Cited by
- 331
- References
- 159
- FWCI
- 18.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Aortic Valve Stenosis: From Basic Mechanisms to Novel Therapeutic Targets. https://app.cochat.ai/papers/10.1161/atvbaha.119.313067
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- Goody, P. R., Hosen, M. R., Christmann, D., Niepmann, S. T., Zietzer, A., Adam, M., Bönner, F., Zimmer, S., Nickenig, G., & Jansen, F. (2020). Aortic Valve Stenosis: From Basic Mechanisms to Novel Therapeutic Targets. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/atvbaha.119.313067
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
