A goal-driven modular neural network predicts parietofrontal neural dynamics during grasping
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Significance: Grasping objects is something primates do effortlessly, but how does our brain coordinate such a complex task? Multiple brain areas across the parietal and frontal cortices of macaque monkeys are essential for shaping the hand during grasping, but we lack a comprehensive model of grasping from vision to action. In this work, we show that multiarea neural networks trained to reproduce the arm and hand control required for grasping using the visual features of objects also reproduced neural dynamics in grasping regions and the relationships between areas, outperforming alternative models. Simulated lesion experiments revealed unique deficits paralleling lesions to specific areas in the grasping circuit, providing a model of how these areas work together to drive behavior.
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A shortcoming of the DNN approach is that it does not predict how an individual neuron causally contributes to behaviour.
“A shortcoming of this approach is that the DNN does not predict how an individual neuron causally contributes to behaviour, making it difficult to interpret the role of the neuron in the sensorimotor transformation.”
From Mapping model units to visual neurons reveals population code for social behaviour (2024) · cites this paper as [16]
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- Authors
- Michaels, J. A., Schaffelhofer, S., Agudelo-Toro, A., & Scherberger, H.
- Affiliations
- Western University (CA)
- German Primate Center (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2020-11-30
- Volume
- 117
- Issue
- 50
- Pages
- 32124-32135
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC7749336
- OpenAlex
- W3107175997
- Cited by
- 103
- References
- 76
- Citations by year
- 2026: 12 · 2025: 20 · 2024: 29 · 2023: 18 · 2022: 11 · 2021: 12 · 2020: 1
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (FOR-1847, B3 (SCHE1575/3-2))
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Keywords
- visually guided grasping, anterior intraparietal area, ventral premotor cortex, primary motor cortex, recurrent neural network model, modular neural networks, muscle kinematics, linear dynamics, lesion models, macaque
- MeSH terms
- Animals, Arm, Female, Frontal Lobe, Hand, Macaca mulatta, Male, Models, Neurological, Motor Activity, Parietal Lobe, Neural Networks, Computer, Hand Strength, Models, Animal
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