Cited by 103Motor Control and AdaptationNeural dynamics and brain functionAction Observation and Synchronization

A goal-driven modular neural network predicts parietofrontal neural dynamics during grasping

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Michaels, Jonathan A., Schaffelhofer, Stefan, Agudelo-Toro, Andres, Scherberger, Hansjörg·2020·Proceedings of the National Academy of Sciences

Abstract

Significance: Grasping objects is something primates do effortlessly, but how does our brain coordinate such a complex task? Multiple brain areas across the parietal and frontal cortices of macaque monkeys are essential for shaping the hand during grasping, but we lack a comprehensive model of grasping from vision to action. In this work, we show that multiarea neural networks trained to reproduce the arm and hand control required for grasping using the visual features of objects also reproduced neural dynamics in grasping regions and the relationships between areas, outperforming alternative models. Simulated lesion experiments revealed unique deficits paralleling lesions to specific areas in the grasping circuit, providing a model of how these areas work together to drive behavior.

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Crossref · 10.1073/pnas.2005087117

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  • A shortcoming of the DNN approach is that it does not predict how an individual neuron causally contributes to behaviour.

    “A shortcoming of this approach is that the DNN does not predict how an individual neuron causally contributes to behaviour, making it difficult to interpret the role of the neuron in the sensorimotor transformation.”

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Authors
Michaels, J. A., Schaffelhofer, S., Agudelo-Toro, A., & Scherberger, H.
Affiliations
  • Western University (CA)
  • German Primate Center (DE)
Venue
Proceedings of the National Academy of Sciences
Published
2020-11-30
Volume
117
Issue
50
Pages
32124-32135
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W3107175997
Cited by
103
References
76
Citations by year
2026: 12 · 2025: 20 · 2024: 29 · 2023: 18 · 2022: 11 · 2021: 12 · 2020: 1
FWCI
5.64
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft (FOR-1847, B3 (SCHE1575/3-2))
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
Keywords
visually guided grasping, anterior intraparietal area, ventral premotor cortex, primary motor cortex, recurrent neural network model, modular neural networks, muscle kinematics, linear dynamics, lesion models, macaque
MeSH terms
Animals, Arm, Female, Frontal Lobe, Hand, Macaca mulatta, Male, Models, Neurological, Motor Activity, Parietal Lobe, Neural Networks, Computer, Hand Strength, Models, Animal

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