Cited by 153SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinationsImmunotherapy and Immune Responses

Avoiding pitfalls in the pursuit of a COVID-19 vaccine

Open access
Peeples, Lynne·2020·Proceedings of the National Academy of Sciences

Abstract

As they race to devise a vaccine, researchers are trying to ensure that their candidates don't spur a counterproductive, even dangerous, immune system reaction known as immune enhancement.

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Crossref · 10.1073/pnas.2005456117

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7 of 7 references verified0 citation errors · 0 not checkable

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  • The Th2-bias hypothesis for T cell immunopathology has not been borne out.

    “The initial emphasis on the T cell immunopathology model came from a Th2-bias hypothesis (Peeples, 2020) and that has not been borne out, as discussed above in the CD4+ T cell section.”

    From Adaptive immunity to SARS-CoV-2 and COVID-19 (2021) · cites this paper as Peeples, 2020

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Authors
Peeples, L.
Corresponding author
Peeples, Lynne
Venue
Proceedings of the National Academy of Sciences
Published
2020-03-30
Volume
117
Issue
15
Pages
8218-8221
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W3013160031
Cited by
152
References
8
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 8 · 2022: 16 · 2021: 56 · 2020: 66
FWCI
4.82
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
COVID-19 vaccines, immune enhancement, vaccine safety, SARS-CoV-2, vaccine candidate, immune response
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Vaccines, Animals, Antigens, Viral, Clinical Trials as Topic, Humans, Inflammation, Pneumonia, Viral, T-Lymphocytes, Viral Vaccines, Coronavirus Infections, Antibody-Dependent Enhancement, Severe Acute Respiratory Syndrome, Pandemics

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