Avoiding pitfalls in the pursuit of a COVID-19 vaccine
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As they race to devise a vaccine, researchers are trying to ensure that their candidates don't spur a counterproductive, even dangerous, immune system reaction known as immune enhancement.
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The Th2-bias hypothesis for T cell immunopathology has not been borne out.
“The initial emphasis on the T cell immunopathology model came from a Th2-bias hypothesis (Peeples, 2020) and that has not been borne out, as discussed above in the CD4+ T cell section.”
From Adaptive immunity to SARS-CoV-2 and COVID-19 (2021) · cites this paper as Peeples, 2020
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Berenbaum, M. R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2006488117 · Cited by 8 · see citing works
Phytochemicals as Potential Curative Agents against Viral Infection: A Review
Kumar, A., Singh, A. K., & Tripathi, G. (2020) · Current Organic Chemistry · doi:10.2174/138527282499920091009352 · Cited by 7 · see citing works
Poteryaev, D. A., Авгатович, Х. Р., Efimov, G. A., & Shuster, А. М. (2020) · Biological Products Prevention Diagnosis Treatment · doi:10.30895/2221-996x-2020-20-3-146-158 · Cited by 7 · see citing works
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Jain, S., Abrham, E., Khan, M., & Mathur, R. (2021) · Aging and Disease · doi:10.14336/ad.2020.1019 · Cited by 7 · see citing works
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Liu, Y., Lam, T. T., Lai, F. Y. L., Krajden, M., Drews, S. J., Hatchette, T. F., Fraaij, P. L. A., van Kampen, J. J. A., Badarch, D., Nymadawa, P., et al. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.04.032 · Cited by 7 · see citing works
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Pandemic number five – Latest insights into the COVID-19 crisis
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Current Status of COVID‐19 (Pre)Clinical Vaccine Development
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Leveraging Nanotechnology for Addressing COVID-19: Revealing Antiviral Approaches and Hurdles
Mostafavi, M., & Shabani, M. (2024) · World Journal of Nano Science and Engineering · doi:10.4236/wjnse.2024.141001 · Cited by 5 · see citing works
Abdullahi, I. N., Emeribe, A. U., Adekola, H. A., Abubakar, S. D., Dangana, A., Shuwa, H. A., Nwoba, S. T., Mustapha, J. O., Haruna, M., Olowookere, A. K., et al. (2020) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2020.1812313 · Cited by 5 · see citing works
- Authors
- Peeples, L.
- Corresponding author
- Peeples, Lynne
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2020-03-30
- Volume
- 117
- Issue
- 15
- Pages
- 8218-8221
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC7165470
- OpenAlex
- W3013160031
- Cited by
- 152
- References
- 8
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 8 · 2022: 16 · 2021: 56 · 2020: 66
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- COVID-19 vaccines, immune enhancement, vaccine safety, SARS-CoV-2, vaccine candidate, immune response
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Vaccines, Animals, Antigens, Viral, Clinical Trials as Topic, Humans, Inflammation, Pneumonia, Viral, T-Lymphocytes, Viral Vaccines, Coronavirus Infections, Antibody-Dependent Enhancement, Severe Acute Respiratory Syndrome, Pandemics
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