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Cited by 633SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesZoonotic diseases and public health

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

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Damas, Joana, Hughes, Graham M., Keough, Kathleen C., Painter, Corrie A., Persky, Nicole S., Corbo, Marco, Hiller, Michael, Koepfli, Klaus-Peter +11 more·2020·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.2010146117PMC PMC7486773

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Abstract

Significance: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a major pandemic that threatens millions of human lives and the global economy. We identified a large number of mammals that can potentially be infected by SARS-CoV-2 via their ACE2 proteins. This can assist the identification of intermediate hosts for SARS-CoV-2 and hence reduce the opportunity for a future outbreak of COVID-19. Among the species we found with the highest risk for SARS-CoV-2 infection are wildlife and endangered species. These species represent an opportunity for spillover of SARS-CoV-2 from humans to other susceptible animals. Given the limited infectivity data for the species studied, we urge caution not to overinterpret the predictions of the present study.

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  • TOGA enables phylogenomic analyses as well as screens for selection patterns and gene losses that are linked to relevant phenotypes.

    “First, by detecting inactivated genes and providing orthologous sequences for codon alignments, TOGA enables phylogenomic analyses as well as screens for selection patterns and gene losses that are linked to relevant phenotypes (6, 35–38).”

    From Integrating gene annotation with orthology inference at scale (2023) · cites this paper as [35]

    The Materials and Methods section, “Identifying Sites Undergoing Positive Selection” (page unavailable), describes codon alignments generated with pal2nal and selection analyses performed with CodeML. Searches for TOGA, inactivated genes, and gene losses found no passage attributing these capabilities to TOGA; the claim therefore cannot be verified from our copy. (LLM, conf=0.76)

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Authors
Damas, J., Hughes, G. M., Keough, K. C., Painter, C. A., Persky, N. S., Corbo, M., Hiller, M., Koepfli, K.-P., Pfenning, A. R., Zhao, H., Genereux, D. P., Swofford, R., Pollard, K. S., Ryder, O. A., Nweeia, M. T., Lindblad-Toh, K., Teeling, E. C., Karlsson, E. K., & Lewin, H. A.
Affiliations
  • University of California, Davis (US)
  • University College Dublin (IE)
  • Gladstone Institutes (US)
  • Broad Institute (US)
  • Max Planck Institute for the Physics of Complex Systems (DE)
  • Smithsonian Conservation Biology Institute (US)
  • Carnegie Mellon University (US)
  • Tibet University (CN)
  • University of California San Diego (US)
  • Smithsonian Institution (US)
  • Broad Institute of MIT and Harvard, Cambridge, MA 02142;
  • Institute of the Environment (US)
Corresponding author
Lewin, Harris A.
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2020-08-21
Volume
117
Issue
36
Pages
22311-22322
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.2010146117
PMC
PMC7486773
OpenAlex
W3080128212
Cited by
633
References
8
Citations by year
2026: 17 · 2025: 39 · 2024: 82 · 2023: 111 · 2022: 149 · 2021: 158 · 2020: 77
FWCI
16.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Uppsala University Publications (Uppsala University) (submittedVersion, other-oa)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • Knut och Alice Wallenbergs Stiftelse (n/a)
  • Irish Research Council (n/a)
  • Roddenberry Foundation (n/a)
  • Gladstone Institutes (n/a)
  • HHS | NIH | National Human Genome Research Institute (R01HG008742)
  • National Science Foundation (2029774)
  • National Natural Science Foundation of China (31722051)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Zoonotic diseases and public health
Keywords
SARS-CoV-2, ACE2, spike protein binding, host range, catarrhine primates, bats, positive selection, accelerated evolution, intermediate hosts, animal model of COVID-19, interspecies transmission
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, Amino Acids, Animals, Binding Sites, Humans, Peptidyl-Dipeptidase A, Pneumonia, Viral, Protein Binding, Receptors, Virus, Selection, Genetic, Genetic Variation, Vertebrates, Coronavirus Infections, Evolution, Molecular, Host Specificity, Pandemics, Spike Glycoprotein, Coronavirus

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