Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells
Open accessAbstract
Significance: Using an approach derived from statistical physics, we quantify transcriptome-wide motif usage in human and murine noncoding RNAs (ncRNAs), determining that most have motif usage consistent with the coding genome. However, an outlier subset of tumor-associated ncRNAs comprises repetitive elements whose motif usage patterns are more typically associated with the genomes of inflammatory pathogens. We demonstrate that a key subset of these elements directly activates the cellular innate immune response. We propose that the innate response in tumors partially originates from direct interaction of immunogenic ncRNAs preferentially expressed in cancer cells with innate pattern recognition receptors.
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Noncoding hSATII RNA is highly expressed in most cancer cells and tissues.
“Previous reports demonstrated that noncoding hSATII RNA is highly expressed in most cancer cells and tissues (27–32).”
From Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment (2023) · cites this paper as [29]
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- Authors
- Tanne, A., Muniz, L. R., Puzio-Kuter, A., Leonova, K. I., Gudkov, A. V., Ting, D. T., Monasson, R., Cocco, S., Levine, A. J., Bhardwaj, N., & Greenbaum, B. D.
- Affiliations
- Tisch Cancer Institute (US)
- Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903;
- Roswell Park Comprehensive Cancer Center (US)
- Massachusetts General Hospital (US)
- Centre National de la Recherche Scientifique (FR)
- Institute for Advanced Study (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-11-02
- Volume
- 112
- Issue
- 49
- Pages
- 15154-15159
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4679042
- OpenAlex
- W1892467251
- Cited by
- 74
- References
- 6
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 11 · 2022: 10 · 2021: 6 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 8 · 2015: 2
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Cancer Institute (5P01CA087497-13, 1R01CA180913-01A1, K12CA087723-11A1)
- HHS | NIH | National Institute of Allergy and Infectious Diseases (5R01AI081848-05)
- Cancer Research Institute (NA)
- Agence Nationale de la Recherche (ANR-13-BS04-0012-01)
- Burroughs Wellcome Fund (1010968.01)
- DOD | U.S. Army (W81XWH-13-1-0237)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- non-coding RNA, immunostimulatory RNA, RNA motifs, CpG, AU-rich elements, repetitive elements, reticuloendothelial system, inflammatory cytokines, tumor microenvironment, tumor immunology
- MeSH terms
- Animals, Humans, Immunity, Innate, Neoplasms, RNA, Untranslated, Mice
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