Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

TOR, a Central Controller of Cell Growth

Schmelzle, T., & Hall, M. N. (2000) · Cell · doi:10.1016/s0092-8674(00)00117-3 · Cited by 1,914

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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Regulation of translation initiation by FRAP/mTOR

Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

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Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

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Mammalian TOR: a homeostatic ATP sensor

Dennis, P. B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S. C., & Thomas, G. (2001) · Science · doi:10.1126/science.1063518 · Cited by 962

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

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The mRNA 5′ cap-binding protein eIF4E and control of cell growth

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Temsirolimus: Safety and Efficacy in the Treatment of Renal Cell Carcinoma

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Targeted Therapeutics in Cancer Treatment

Weekes, C. D., & Hidalgo, M. M. (2007) · Elsevier eBooks · doi:10.1016/b978-012372551-6/50072-9 · Cited by 1

Contractile and Genetic Characterization of Cardiac Constructs Engineered from Human Induced Pluripotent Stem Cells: Modeling of Tuberous Sclerosis Complex and the Effects of Rapamycin

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Atypical case of tuberous sclerosis with isolated neurologic findings: A case report

Devkota, S., Bhatta, O. P., Kalikote, A., Gyawali, P., & Lamichhane, S. (2024) · Clinical Case Reports · doi:10.1002/ccr3.9379 · Cited by 1

TSC2 gene characterization and mechanism of ammonia nitrogen stress inhibiting growth through AMPK/mTOR pathway mediated by TSC2 in Megalobrama amblycephala

Yuan, X., Wang, Q., Dai, M., Wang, H., Xiong, X., Pan, L., & Wang, C. (2024) · Aquaculture Reports · doi:10.1016/j.aqrep.2024.102342 · Cited by 1

Nonfunctioning Pancreatic Neuroendocrine Tumors

Koumarianou, A. A., & Fazio, N. (2015) · Springer eBooks · doi:10.1007/978-3-662-45215-8_18 · Cited by 1

Signaling Pathways that Mediate Translational Control of Ribosome Recruitment to mRNA

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Metabolic Shunt Pathways, Carcinoma, and mTOR

Shibuya, N., Inoue, K.-I., & Kubota, K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802733-2.00022-0 · Cited by 2

Current Status of mTOR Inhibitors as Novel Therapeutic Agents

Kurady, L. B. (2017) · Journal of global pharma technology · Cited by 1

Metformin and mTOR Inhibitors: Allies against Ovarian and Breast Cancers

Guimarães, I. D. S., Tessarollo, N. G., dos Santos, D. Z., de Souza, M. L. M., Henriques, T. B., Silva, I. V., & Rangel, L. B. A. (2017) · Journal of Carcinogenesis & Mutagenesis · doi:10.4172/2157-2518.1000299 · Cited by 1

Aberrant Cellular Pathways in PKD

Grazioli, A., Outeda, P., & Watnick, T. J. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7784-0_4 · Cited by 1

Neurocutaneous Syndromes

Islam, M. P. (2020) · Springer eBooks · doi:10.1007/978-3-319-43153-6_13 · Cited by 1

Non-Functioning Pancreatic Neuroendocrine Tumors

Fazio, N., & Koumarianou, A. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-56968-5_18 · Cited by 1

Regulation of the mammalian target of rapamycin complex 2 (mTORC2)

Molle, K. D. (2006) · edoc (University of Basel) · doi:10.5451/unibas-004670272 · Cited by 1

The Physiological Function of Beclin, a Novel BCL-2 Interacting Protein in Protein Trafficking

Zeng, X. (2005) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 1

Renal Cell Carcinoma and Targeted Therapy

Gartrell, B. A., Small, A., Oh, W. K., & Galsky, M. D. (2015) · doi:10.1002/9781118468678.ch29 · Cited by 1

TSC1 loss-of-function increases risk for tauopathy by inducing tau acetylation and preventing autophagy-mediated tau clearancePreprint

Alquézar, C., Schoch, K. M., Geier, E. G., Ramos, E. M., Scrivo, A., Li, K. K., Argouarch, A. R., Mlynarski, E. E., Dombroski, B. A., Yokoyama, J. S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.08.371922 · Cited by 1

STAT3 regulates the generation of astroglia in human brain organoids with high mTORC1 activityPreprint

Deb, B. K., Li, T. L., Blair, J. D., Hockemeyer, D. F., & Bateup, H. S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.21.572786 · Cited by 1

Control of Protein Synthesis by Insulin

Christian, J. F., & Lawrence, J. C. (2007) · Springer eBooks · doi:10.1007/978-0-387-72204-7_4 · Cited by 1

Skeletal muscle regulatory factors with alterations in muscle mass

Miller, L., & Michele, J. (2007) · Summit (Simon Fraser University) · Cited by 1

Hormonal and Nutrient Signalling to Protein Kinase B and Mammalian Target of Rapamycin in Pancreatic Beta-Cells

Mostafa, N. M. E.-S. B. E.-D. (2012) · Figshare · Cited by 1

Targeted Therapeutics in Cancer Treatment

Weekes, C. D., & Hidalgo, M. M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7358-0_15

The functional roles of the intra-oocyte phosphatidylinositol 3-kinase (PI3K) signaling in controlling follicular development in mice

Jagarlamudi, K. (2009) · DiVA at Umeå University (Umeå University)

Current and Novel Approaches for Genetic Skin Disorders

Lai‐Cheong, J. E., & Paller, A. S. (2013) · Springer eBooks · doi:10.1007/978-3-642-39532-1_11

Regulation of peripheral nerve regeneration by the mTOR pathway

Abe, N. (2010) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7k64g37

Ovarian Cancer Training Program at the Dana Farber/Harvard Cancer Center

Seiden, M. V. (2004) · doi:10.21236/ada425655

CHARACTERIZATION AND TREATMENT OF A NOVEL MOUSE MODEL OF TSC-ASSOCIATED AUTISM

Reith, R. M. (2012) · Digital Commons-TMC (Texas Medical Center)

Leucine and exercise improve skeletal muscle function in the mdx mouse

Voelker, K. A. (2010) · VTechWorks (Virginia Tech)

Las Bases Moleculares del Cáncer

Pérez, J. C. R. (2006) · Acta Universitaria · doi:10.15174/au.2006.202

Rabdomiomas cardiacos múltiples en dos neonatos

Soria-Céspedes, D., Durán-Padilla, M. A., David Aguirre, Q., & Romero, M. (2007) · Revista Médica Del Hospital General De México

Combinations of Cytotoxic Drugs, Ionizing Radiation, and Mammalian Target of Rapamycin (mTOR) Inhibitors

Sarkaria, J. N. (2006) · Springer eBooks · doi:10.1007/3-540-35662-2_9

Targeting cancer with reovirus.

Comins, C. (2015) · Surrey Research Insight Open Access (The University of Surrey)

Targeting Signal Transduction Pathways for the Treatment of Kaposi Sarcoma

Douglas, J. L., Koon, H. B., & Moses, A. V. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1513-9_5

Familial or Infectious…or Both? the Complexity of Confirming Causality of Cortical Malformations

Gilliam, F. G. (2014) · Epiliepsy currents/Epilepsy currents · doi:10.5698/1535-7597-14.5.259

Sclerosing fibroma formed in the chin in a patient with tuberous sclerosis complex: A ten-year followed-up case after the operation

Yanagibashi, K., Hayashi, T., Itoh, M., Orikawa, H., Shinnakasu, M., Hirahara, N., & Hayashi, N. (2012) · Journal of Oral and Maxillofacial Surgery Medicine and Pathology · doi:10.1016/j.ajoms.2011.12.007

Everolimus for renal cell carcinoma: predictive factors for response and future directions

Sonpavde, G., & Hutson, T. E. (2009) · Medical Oncology · doi:10.1007/s12032-008-9150-3

The Biological Role of mTOR in the Pathogenesis of Solid Tumors: An Overview

Koropouli, E., Manolopoulos, L., Pandha, H., & Syrigos, K. (2009) · Current Enzyme Inhibition · doi:10.2174/157340809787314274

Angiomyolipome Rénal et Sclérose Tubéreuse de Bourneville: Revue de la Littérature à Propos de Deux Cas.

Ghoundale, O., Hjira, N., Erregragui, Y., & Touiti, D. (2011) · African Journal of Urology · doi:10.1007/s12301-011-0019-x

Characterising the tumour suppression function of folliculin

Preston, R. S. (2013) · ORCA Online Research @Cardiff (Cardiff University)

Early clinical cancer trials: Proof of concept and beyond

Konings, I. R. H. M. (2011) · EUR Research Repository (Erasmus University Rotterdam)

Effects of immunosuppressive drugs on human adipose tissue metabolism

Pereira, M. J. (2012) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Reducing infarct size by ischemic preconditioning versus insulin treatment in the heart : same outcome - similar mechanisms?

Fuglesteg, B. N. (2008) · NORA - Norwegian Open Research Archives

Tuberous Sclerosis: Genetics

Tee, A. R., Sampson, J. R., & Davies, D. M. (2012) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0005934.pub2

Renal Cell Carcinoma

Hahn, O. M., & Stadler, W. M. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-337-0_11

Dynamic tubers in tuberous sclerosis complex

Ess, K. C., & Chugani, H. T. (2015) · Neurology · doi:10.1212/wnl.0000000000002056

AMPK and Metabolic Remodeling in Cardiac Disease

Pulinilkunnil, T., Nagendran, J., & Dyck, J. R. B. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-891-7_5

Molecular Neurooncology and Neoangiogenesis of Malignant Gliomas

Hutterer, M., & Stockhammer, G. (2009) · Springer eBooks · doi:10.1007/978-3-642-00475-9_2

Biologie des Melanoms: Signaltransduktionsmolekule als Zielstrukturen für die Melanomtherapie

Schittek, B., Sinnberg, T. W., & Meier, F. E. (2006) · Springer eBooks · doi:10.1007/3-540-28988-7_2

PI3K, PTEN and Akt

Franke, T. F., & Berwick, D. C. (2005) · Springer eBooks · doi:10.1007/3-540-27194-5_20

The Role of SAD-1 Kinase in Caenorhabditis elegans Neuronal Circuit Development and Function

Pekar, T. (2013) · TSpace (University of Toronto)

The regulation of protein synthesis in adult rat cardiomyocytes

Huang, B. (2008) · cIRcle (University of British Columbia) · doi:10.14288/1.0066408

Targeting acute phosphatase PTEN inhibition and investigation of a novel combination treatment with Schwann cell transplantation to promote spinal cord injury repair in rats

Walker, C. L. (2014) · IUScholarWorks (Indiana University) · doi:10.7912/c2/2098

Role of mTORC1 and Autophagy in the Regulation of Chemoresistance in Leukemic B-Cells

Sharma, A. (2014) · EngagedScholarship @ Cleveland State University (Cleveland State University)

Function of mTOR complex 1 and 2 in Skeletal Muscle

Fakultät, P.-N. (2009)

Progress in Cancer Genomic Medicine: A Year in Review, 2012

Markman, M. M. (2012)

CIRCADIAN REGULATION OF mTOR SIGNALING VIA BMAL1 DEPENDENT MECHANISM

Khapre, R. V. (2014) · OhioLink ETD Center (Ohio Library and Information Network)

Familial or Infectious…or Both? The Complexity of Confirming Causality of Cortical Malformations

Leventer, R. J., Jansen, E., Ho, A., Mohamed, I., Sarnat, H. B., Kato, M., Fukasawa, T., Saitsu, H., Matsumoto, N., Itoh, M., et al. (2014)

Regulation of autophagy and cell death in breast carcinoma cells

Koterba, K. L. (2010) · OhioLink ETD Center (Ohio Library and Information Network)

MECCANISMI DI CONTROLLO DELLA NEOSINTESI PROTEICA IN FIBROCELLULE MUSCOLARI

Ricerca, D. D. (2007)

by AICAR myotubes following AMPK activation 12 C 2 synthesis in C Time course changes in signaling pathways and protein

Williamson, D. L., Bolster, D. R., Kimball, S. R., & Jefferson, L. S. (2016)

Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders

Laurence, A. D. J., Masters, S. L., & O’Shea, J. J. (2008) · Elsevier eBooks · doi:10.1016/b978-0-323-04404-2.10091-0

Regulation of NFAT5 by signaling pathways involved in osmotic stress responses and cell growth

Armisen, B. M. (2008) · Repositori digital de la UPF (Universitat Pompeu Fabra)

Skeletal Muscle Atrophy and Hypertrophy

Glass, D. J. (2005) · CRC Press eBooks · doi:10.1201/9780849333798.ch3

IMPLICATIONS OF MITOTIC ONSET REGULATION IN TUBEROUS SCLEROSIS

Dare-Shih, J. (2016) · Scholarship at UWindsor (University of Windsor)

Effect of Akt (PKB) on the activity of mammalian target of rapamycin (mTOR)

Hahn-Windgassen, A. (2005) · doi:10.14279/depositonce-820

New Indications of mTOR Inhibitors in Rare Tumors

Shah, G., Stergiopoulos, S. G., & Lebwohl, D. (2015) · Springer eBooks · doi:10.1007/978-2-8178-0492-7_6

mTORC1 contributes to ER stress induced cell death

Babcock, J. T. (2014) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1843

Molecular Genetics of Gastroenteropancreatic Neuroendocrine Tumours

Backman, S., & Björklund, P. (2016) · Springer eBooks · doi:10.1007/978-3-319-46038-3_6

Signaling Pathways That Mediate Translational Control of Ribosome Recruitment to mRNA

Sonenberg, N., & Petroulakis, E. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50684-7

Identification of interacting partners of mammalian target of rapamycin complex 1 (mTORC1) assembly in human lymphocytes

Rahman, H. (2012) · doi:10.53846/goediss-528

Phakomatoses-Neurocutaneous Syndromes

Leitenberger, S., Mason, M. N., Coryell, J. C., Enzenauer, R. W., & Karr, D. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-18389-3_16

Phosphatidic Acid Increases Lean Body Tissue And Strength In Resistance Trained Men

Williams, D. R. (2012) · Journal of International Crisis and Risk Communication Research

Drug delivery to osteoclast receptor targets

Kalvapalle, R. (2009) · doi:10.7939/r3ts7w

Skeletal Muscle Growth Responses to Voluminous Resistance Training in Young Men with or without Graded Dosage of Protein Supplementation

Haun, C. T. (2018)

Crosstalk between mTORC1 and cAMP Signaling

Guan, K. (2015)

Evaluating downstream targets of cullin4-dependent E3 ligases and of D-type cyclins: implications for the dysregulation of ubiquitination and cell growth in cancer

Zacharek, S. J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/tp9d-5n23

Genetics of autism spectrum disorders

Gupta, A. R., Fernandez, T. V., & Hoffman, E. J. (2020) · doi:10.1093/med/9780198713005.003.0028

Approach to the patient with tuberous sclerosis

Silvia, M., & Strowd, R. E., III (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-69494-0.00017-8

Targeting the phosphatidylinositol 3-kinase signaling pathway in acute myeloid leukemia

Fuchs, O. (2020) · Integrative Cancer Science and Therapeutics · doi:10.15761/icst.1000342

Dual Target of EGFR and mTOR Suppress Triple Negative Breast Cancer Cell Growth Via Regulation The Phosphorylation of mTOR Downstream ProteinsPreprint

Ma, J., Li, H., Cao, Y., Fan, J., & Ma, B. (2021) · Research Square · doi:10.21203/rs.3.rs-1033131/v1

Fibrous Proliferations

Phung, T. L., Wright, T. S., Pourciau, C. Y., & Smoller, B. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-44824-4_25

The Phakomatoses

Ariss, M. M., Ragge, N., Moodley, M., & Traboulsi, E. I. (2012) · doi:10.1093/med/9780195326147.003.0046

Neuropsychological Problems in Neuro-Oncology

Armstrong, C. L., Schmus, C. J., Belasco, J. B., & Li, Y. (2019) · Springer eBooks · doi:10.1007/978-3-030-14895-9_4

mTOR

Easton, J. B., & Houghton, P. J. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-337-0_2

Neuro-Ophthalmologic Manifestations of Systemic and Intracranial Disease

Brodsky, M. C. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3384-6_11

Retinal Astrocytic Tumors

Lee, C. S., Lee, S., & Singh, A. D. (2019) · Springer eBooks · doi:10.1007/978-3-030-04113-7_4

Skeletal Muscle Atrophy and Hypertrophy

Glass, D. J. (2005) · CRC Press eBooks · doi:10.1201/9781420048957.ch3

Dissecting the Roles of the Tuberin Protein in the Subcellular Localization of the G2/M Cyclin, Cyclin B1Preprint

Dare-Shih, J., Pillon, A., Fong, J., da Silva, E. F., & Porter, L. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.25.465800

S6K1

Dennis, P. B., & Thomas, G. (2008) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a000530.01

The role of PI3K/AKT/TSC/p70S6K1 pathway in tumor growth and angiogenesis

Meng, Q. (2006) · doi:10.33915/etd.2513

Faculty Opinions recommendation of Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma.

DeMorrow, S. (2008) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1115376.571398

Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease

Kim, D., Park, G., Huuhtanen, J., Lundgren, S., Khajuria, R., Hurtado, A., Muñoz‐Calleja, C., Cardenoso, L., de Sora, V., Chen-Liang, T., et al. (2020) · immuneACCESS · doi:10.21417/dk2020nc

mTOR pathway inhibition stimulates pharmacologically induced nonsense suppressionPreprint

Wittenstein, A., Caspi, M., Rippin, I., Elroy‐Stein, O., Eldar-Finkelman, H., Thoms, S., & Rosin‐Arbesfeld, R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.31.506003

Kinase Inhibitors in Genetic Diseases

D’Antona, L., Amato, R., Brescia, C., Rocca, V., Colao, E., Iuliano, R., Blazer‐Yost, B. L., & Perrotti, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065276

Data from The PTEN/Akt Pathway Dictates the Direct αVβ3-Dependent Growth-Inhibitory Action of an Active Fragment of Tumstatin in Glioma Cells In vitro and In vivo

Kawaguchi, T., Yamashita, Y., Kanamori, M., Endersby, R., Bankiewicz, K. S., Baker, S. J., Bergers, G., & Pieper, R. O. (2023) · doi:10.1158/0008-5472.c.6494756

Data from The PTEN/Akt Pathway Dictates the Direct αVβ3-Dependent Growth-Inhibitory Action of an Active Fragment of Tumstatin in Glioma Cells In vitro and In vivo

Kawaguchi, T., Yamashita, Y., Kanamori, M., Endersby, R., Bankiewicz, K. S., Baker, S. J., Bergers, G., & Pieper, R. O. (2023) · doi:10.1158/0008-5472.c.6494756.v1

Data from Optimized EGFR Blockade Strategies in EGFR Addicted Gastroesophageal Adenocarcinomas

Corso, S., Pietrantonio, F., Apicella, M., Migliore, C., Conticelli, D., Petrelli, A., D’Errico, L., Durando, S., Moya-Rull, D., Bellomo, S. E., et al. (2023) · doi:10.1158/1078-0432.c.6530756

Data from Ridaforolimus (AP23573; MK-8669), a Potent mTOR Inhibitor, Has Broad Antitumor Activity and Can Be Optimally Administered Using Intermittent Dosing Regimens

Rivera, V. M., Squillace, R. M., Miller, D., Berk, L., Wardwell, S., Ning, Y., Pollock, R. M., Narasimhan, N. I., Iuliucci, J. D., Wang, F., et al. (2023) · doi:10.1158/1535-7163.c.6535203

Data from Ridaforolimus (AP23573; MK-8669), a Potent mTOR Inhibitor, Has Broad Antitumor Activity and Can Be Optimally Administered Using Intermittent Dosing Regimens

Rivera, V. M., Squillace, R. M., Miller, D., Berk, L., Wardwell, S., Ning, Y., Pollock, R. M., Narasimhan, N. I., Iuliucci, J. D., Wang, F., et al. (2023) · doi:10.1158/1535-7163.c.6535203.v1

Suplementação de glutamina e glutamato em dietas com baixo nível de lisina digestível para leitões desmamados

Dórea, E. S. (2022) · doi:10.47328/ufvbbt.2022.694

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., & Blenis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00506-2 · Cited by 1,080

Tumour suppressors hamartin and tuberin: intracellular signalling

Krymskaya, V. P. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(03)00040-8 · Cited by 130

Tuberous sclerosis complex and the mTOR pathway

Kim, K. J. (2011)

Hamartin and tuberin: Working together for tumour suppression

Jóźwiak, J. (2005) · International Journal of Cancer · doi:10.1002/ijc.21542 · Cited by 87

Kinases meet at TSC

Wu, Y., & Zhou, B. P. (2007) · Cell Research · doi:10.1038/cr.2007.106 · Cited by 13