Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
Tee, Andrew R., Fingar, Diane C., Manning, Brendan D., Kwiatkowski, David J., Cantley, Lewis C., Blenis, John·2002·Proceedings of the National Academy of Sciences
Cited by (828)
Items 101–200 of 828
- Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cellsChen, Long, Xu, Baoshan, Liu, Lei, Luo, Yan, Yin, Jun, Zhou, Hongyu, Chen, Wenxing, Shen, Tao, Han, Xiuzhen, Huang, Shile · 2010 · Laboratory Investigation
- TSC1 Stabilizes TSC2 by Inhibiting the Interaction between TSC2 and the HERC1 Ubiquitin LigaseChong-Kopera, Huira, Inoki, Ken, Li, Yong, Zhu, Tianqing, Garcia-Gonzalo, Francesc R., Rosa, Jose Luis, Guan, Kun-Liang · 2006 · Journal of Biological Chemistry
- Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of Tuberous Sclerosis ComplexL.-H. Zeng, Nicholas R. Rensing, B. Zhang, David H. Gutmann, Michael J. Gambello, Michael Wong · 2010 · Human Molecular Genetics
- Staying aliveJames R. Valcourt, Johanna M. S. Lemons, Erin M. Haley, Mina L. Kojima, Olukunle O. Demuren, Hilary A. Coller · 2012 · Cell Cycle
- mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of ActionGhada A. Soliman, Hugo A. Acosta-Jaquez, Elaine A. Dunlop, Bilgen Ekim Üstünel, Nicole E. Maj, Andrew R. Tee, Diane C. Fingar · 2009 · Journal of Biological Chemistry
- Protein interactome reveals converging molecular pathways among autism disordersSakai, Yasunari, Shaw, Chad A., Dawson, Brian C., Dugas, Diana V., Al-Mohtaseb, Zaina, Hill, David E., Zoghbi, Huda Y. · 2011 · Science Translational Medicine
- Metabolic transformation in cancerDaniel A. Tennant, Raúl V. Durán, Houda Boulahbel, Eyal Gottlieb · 2009 · Carcinogenesis
- Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signallingDouglas R. Bolster, Leonard S. Jefferson, Scot R. Kimball · 2004 · Proceedings of The Nutrition Society
- Multiple amino acid sensing inputs to mTORC1Mitsugu Shimobayashi, Michael N. Hall · 2015 · Cell Research
- Inactivation of the Tuberous Sclerosis Complex-1 and -2 Gene Products Occurs by Phosphoinositide 3-Kinase/Akt-dependent and -independent Phosphorylation of TuberinAndrew R. Tee, Rana Anjum, John Blenis · 2003 · Journal of Biological Chemistry
- Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral NervesNamiko Abe, Steven Borson, Michael J. Gambello, Fan Wang, Valeria Cavalli · 2010 · Journal of Biological Chemistry
- Sustained Activation of the JNK Cascade and Rapamycin-Induced Apoptosis Are Suppressed by p53/p21Cip1Shile Huang, Lili Shu, Michael B. Dilling, John B. Easton, Franklin C. Harwood, Hidenori Ichijo, Peter J. Houghton · 2003 · Molecular Cell
- Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic FunctionBateup, H. S., Takasaki, K. T., Saulnier, J. L., Denefrio, C. L., Sabatini, B. L. · 2011 · Journal of Neuroscience
- Chapter 1 Physiological Roles of Ribosomal Protein S6: One of Its KindOded Meyuhas · 2008 · International review of cytology
- Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in CancerEvan C. Lien, Costas Andreas Lyssiotis, Lewis C. Cantley · 2016 · Recent results in cancer research/Recent Results in Cancer Research
- Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressorsBryan A. Ballif, Philippe P. Roux, Scott A. Gerber, Jeffrey P. MacKeigan, John Blenis, Steven P. Gygi · 2005 · Proceedings of the National Academy of Sciences
- Comprehensive Proteomic Analysis of Interphase and Mitotic 14-3-3-binding ProteinsSarah E. M. Meek, William S. Lane, Helen M. Piwnica-Worms · 2004 · Journal of Biological Chemistry
- Tuberous sclerosis complex: linking growth and energy signaling pathways with human diseaseAristotelis Astrinidis, Elizabeth P. Henske · 2005 · Oncogene
- Mammalian target of rapamycin inhibition as therapy for hematologic malignanciesAmit W. Panwalkar, Srđan Verstovšek, Francis Joseph Giles · 2004 · Cancer
- Genetically engineered human cortical spheroid models of tuberous sclerosisJohn D. Blair, Dirk F. Hockemeyer, Helen S. Bateup · 2018 · Nature Medicine
- Distinct Signaling Events Downstream of mTOR Cooperate To Mediate the Effects of Amino Acids and Insulin on Initiation Factor 4E-Binding ProteinsXuemin Wang, Anne Beugnet, Mirei Murakami, Shinya Yamanaka, Christopher G. Proud · 2005 · Molecular and Cellular Biology
- Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: from tuberous sclerosis to common acquired epilepsies.Wong, Michael · 2010 · Epilepsia
- Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor ComplexChristopher S. Beevers, Long Chen, Lei Liu, Yan Luo, Nicholas J. G. Webster, Shile Huang · 2009 · Cancer Research
- Changes in Lung Function and Chylous Effusions in Patients With Lymphangioleiomyomatosis Treated With SirolimusAngelo M. Taveira‐DaSilva, Olanda M. Hathaway, Mario P. Stylianou, Joel Moss · 2011 · Annals of Internal Medicine
- Human Cytomegalovirus Protein UL38 Inhibits Host Cell Stress Responses by Antagonizing the Tuberous Sclerosis Protein ComplexMoorman, Nathaniel J., Cristea, Ileana M., Terhune, Scott S., Rout, Michael P., Chait, Brian T., Shenk, Thomas · 2008 · Cell Host & Microbe
- Class I A Phosphoinositide 3-Kinase Regulates Heart Size and Physiological Cardiac HypertrophyJi Luo, Julie R. McMullen, Cassandra L. Sobkiw, Li Zhang, Adam L. Dorfman, Megan C. Sherwood, M. Nicole Logsdon, James W. Horner, Ronald Anthony DePinho, Seigo Izumo et al. · 2005 · Molecular and Cellular Biology
- Defining the underlying defect in insulin action in type 2 diabetesThiago M. Batista, Nida Haider, C. Ronald Kahn · 2021 · Diabetologia
- Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cellsLihong Wang, Cresson D. Fraley, Jesika S. Faridi, Arthur Kornberg, Richard A. Roth · 2003 · Proceedings of the National Academy of Sciences
- LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAsSungki Hong, Mallory Freeberg, Ting Han, Avani Kamath, Yao Yao, Tomoko Fukuda, Tsukasa Suzuki, John K. Kim, Ken Inoki · 2017 · eLife
- Ras, PI3-kinase and mTOR signaling in cardiac hypertrophyChristopher G. Proud · 2004 · Cardiovascular Research
- mTOR signaling in stem and progenitor cellsDelong Meng, Anderson R. Frank, Jenna L. Jewell · 2018 · Development
- Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863 and Multisite PhosphorylationKathryn G. Foster, Hugo A. Acosta-Jaquez, Yves Roméo, Bilgen Ekim Üstünel, Ghada A. Soliman, Audrey Carriere, Philippe P. Roux, Bryan A. Ballif, Diane C. Fingar · 2009 · Journal of Biological Chemistry
- Integration of Growth Factor and Nutrient SignalingAlykhan F. Shamji, Paul Nghiem, Stuart L. Schreiber · 2003 · Molecular Cell
- The mTOR pathway and its role in human genetic diseasesM ROSNER, Michaela Hanneder, Nicol Siegel, Alessandro Valli, Christiane Fuchs, M HENGSTSCHLAGER · 2008 · Mutation Research/Reviews in Mutation Research
- Training for Endurance and StrengthKeith Baar · 2006 · Medicine & Science in Sports & Exercise
- Behavioral phenotypes of genetic mouse models of autismTatiana M. Kazdoba, Prescott T. Leach, Jacqueline N. Crawley · 2015 · Genes Brain & Behavior
- Phospholipase D1 is an effector of Rheb in the mTOR pathwayYu Sun, Yimin Fang, Mee‐Sup Yoon, Conghao Zhang, Marta Roccio, Fried J. T. Zwartkruis, Michelle D. Armstrong, H. Alex Brown, Jie Chen · 2008 · Proceedings of the National Academy of Sciences
- Regulation of Body Size and Growth ControlMichael James Texada, Takashi Koyama, Kim Rewitz · 2020 · Genetics
- mTORC1 and Nutrient Homeostasis: The Central Role of the LysosomeYoana Rabanal‐Ruiz, Viktor I. Korolchuk · 2018 · International Journal of Molecular Sciences
- Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activationAgus Suryawan, Asumthia S. Jeyapalan, Renán A. Orellana, Fiona A. Wilson, Hanh V. Nguyen, Teresa A. Davis · 2008 · American Journal of Physiology-Endocrinology and Metabolism
- Airway Smooth Muscle Growth in Asthma: Proliferation, Hypertrophy, and MigrationJohn Kelley Bentley, Marc B. Hershenson · 2007 · Proceedings of the American Thoracic Society
- Signaling control of mRNA translation in cancer pathogenesisEric C. Holland, Nahum Sonenberg, Pier Paolo Pandolfi, George Thomas · 2004 · Oncogene
- Tuberous Sclerosis ComplexFrancis J. DiMario, Mustafa Şahin, Darius Ebrahimi‐Fakhari · 2015 · Pediatric Clinics of North America
- Mammalian Target of Rapamycin (mTOR) Pathways in Neurological DiseasesMichael Wong · 2013 · Biomedical Journal
- Site-Specific mTOR Phosphorylation Promotes mTORC1-Mediated Signaling and Cell GrowthHugo A. Acosta-Jaquez, Jennifer A. Keller, Kathryn G. Foster, Bilgen Ekim Üstünel, Ghada A. Soliman, Edward P. Feener, Bryan A. Ballif, Diane C. Fingar · 2009 · Molecular and Cellular Biology
- mTOR signaling in tumorigenesisKai Lin Xu, Pengda Liu, Wenyi Wei · 2014 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Role of mTOR Signaling in Female ReproductionZaixin Guo, Qi Yu · 2019 · Frontiers in Endocrinology
- Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent mannerJayanta Debnath, Stephanie J. Walker, Joan S. Brugge · 2003 · The Journal of Cell Biology
- The p38 and MK2 Kinase Cascade Phosphorylates Tuberin, the Tuberous Sclerosis 2 Gene Product, and Enhances Its Interaction with 14-3-3Yong Li, Ken Inoki, Panayiotis O. Vacratsis, Kun‐Liang Guan · 2003 · Journal of Biological Chemistry
- AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinaseBenjamin Ate Kefas, Ying Cai, Z. Ling, Harry Heimberg, L. Hue, DANIEL G. PIPELEERS, Mark Van de Casteele · 2003 · Journal of Molecular Endocrinology
- Genetic Variations in the PI3K/PTEN/AKT/mTOR Pathway Are Associated With Clinical Outcomes in Esophageal Cancer Patients Treated With ChemoradiotherapyMichelle A.T. Hildebrandt, Hushan Yang, Mien‐Chie Hung, Julie G. Izzo, Maosheng Huang, Jie Ming Lin, Jaffer A. Ajani, Xifeng Wu · 2009 · Journal of Clinical Oncology
- Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin.Nisreen El-Hashemite, Victoria Walker, Hongbing Zhang, David J. Kwiatkowski · 2003 · PubMed
- Tuberous sclerosis complex: from Drosophila to human diseaseDuojia Pan, Jixin Dong, Yong Zhang, Xinsheng Gao · 2004 · Trends in Cell Biology
- The role of autophagy in hepatocellular carcinoma: friend or foeLian Liu, Jiazhi Liao, Xingxing He, Peiyuan Li · 2017 · Oncotarget
- Targeting the molecular target of rapamycin (mTOR)Eric Keith Rowinsky · 2004 · Current Opinion in Oncology
- Cyclin D1 and c-myc Internal Ribosome Entry Site (IRES)-dependent Translation Is Regulated by AKT Activity and Enhanced by Rapamycin through a p38 MAPK- and ERK-dependent PathwayYijiang Shi, Anushree Sharma, Hong Wu, Alan K. Lichtenstein, Joseph Gera · 2005 · Journal of Biological Chemistry
- Biallelic TSC gene inactivation in tuberous sclerosis complexCrino, Peter B., Aronica, Eleonora, Baltuch, Gordon, Nathanson, Katherine L. · 2010 · Neurology
- Genetic Causes of Brain Tumors: Neurofibromatosis, Tuberous Sclerosis, von Hippel-Lindau, and Other SyndromesChristopher James Farrell, Scott Randall Plotkin · 2007 · Neurologic Clinics
- Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesisHerbert B. Newton · 2004 · Expert Review of Anticancer Therapy
- The Complexes of Mammalian Target of RapamycinHongyu Zhou, Shile Huang · 2010 · Current Protein and Peptide Science
- The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partnersMargit Rosner, Michaela Hanneder, Nicol Siegel, Alessandro Valli, Markus Hengstschläger · 2008 · Mutation Research/Reviews in Mutation Research
- Tuberous sclerosis complex: genetics to pathogenesisVinodh Narayanan · 2003 · Pediatric Neurology
- Dietary intervention in acneBodo Clemens Melnik · 2012 · Dermato-Endocrinology
- Leucine signaling in the pathogenesis of type 2 diabetes and obesityBodo Clemens Melnik · 2012 · World Journal of Diabetes
- The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissueShogo Wada, Michael D. Neinast, Cholsoon Jang, Yasir H. Ibrahim, Gina Lee, Apoorva Babu, Jian Li, Atsushi Hoshino, Glenn C. Rowe, James Rhee et al. · 2016 · Genes & Development
- mTOR signaling for biological control and cancerAnya Alayev, Marina K. Holz · 2013 · Journal of Cellular Physiology
- Regulation of mTOR by amino acids and resistance exercise in skeletal muscleLouise Deldicque, Daniel Theisen, Marc Francaux · 2005 · European Journal of Applied Physiology
- Inhibition of Autophagosome Formation by the Benzoporphyrin Derivative VerteporfinElizabeth Donohue, Andrew Norman Tovey, A. Wayne Vogl, Steve Arns, Ethan D. Sternberg, Robert Norman Young, Michel Roberge · 2010 · Journal of Biological Chemistry
- Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survivalEnrique Rozengurt, James W. Sinnett‐Smith, Guido Eibl · 2018 · Signal Transduction and Targeted Therapy
- Regulation of the small GTPase Rheb by amino acidsMarta Roccio, Johannes L. Bos, Fried J. T. Zwartkruis · 2005 · Oncogene
- Causes of mortality in individuals with tuberous sclerosis complexSam Amin, Andrew L. Lux, Nuala Calder, Matthew J. Laugharne, John P Osborne, Finbar J. O'Callaghan · 2016 · Developmental Medicine & Child Neurology
- Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunctionCondon, Kendall J., Orozco, Jose M., Adelmann, Charles H., Spinelli, Jessica B., van der Helm, Pim W., Roberts, Justin M., Kunchok, Tenzin, Sabatini, David M. · 2021 · Proceedings of the National Academy of Sciences
- PI3-kinase and TOR: PIKTORing cell growthCeleste J. Richardson, Stefanie S. Schalm, John Blenis · 2004 · Seminars in Cell and Developmental Biology
- Genotype and psychological phenotype in tuberous sclerosisJ C Lewis, H V Thomas, K C Murphy, J R Sampson · 2004 · Journal of Medical Genetics
- Epileptogenesis and Reduced Inward Rectifier Potassium Current in Tuberous Sclerosis Complex‐1–Deficient AstrocytesLaura A. Jansen, Erik J. Uhlmann, Peter B. Crino, David H. Gutmann, Michael Wong · 2005 · Epilepsia
- When Overgrowth Bumps Into Cancer: The PTEN-OpathiesJessica L. Mester, Charis Eng · 2013 · American Journal of Medical Genetics Part C Seminars in Medical Genetics
- The mammalian target of rapamycin-signaling pathway in regulating metabolism and growth1,2X. Yang, C.B. Yang, A. Farberman, Todd Christopher Rideout, C. F. M. de Lange, J. France, Ming Z. Fan · 2007 · Journal of Animal Science
- Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPaseMasahiro Uritani, Hidetoshi Hidaka, Yukari Hotta, Masaru Ueno, Takashi Ushimaru, Takashi Toda · 2006 · Genes to Cells
- The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and AgingStephanie Fernandes, Constantinos Demetriades · 2021 · Frontiers in Aging
- Management of subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC): Clinical recommendationsSergiusz Jóźwiak, Rima Nabbout, Paolo Curatolo · 2013 · European Journal of Paediatric Neurology
- Mechanisms of Kaempferol in the treatment of diabetes: A comprehensive and latest reviewYan Yang, Zhengtao Chen, Xiaoyan Zhao, Hongyan Xie, Lian Du, Hong Li Gao, Chunguang Xie · 2022 · Frontiers in Endocrinology
- mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle ProgressionBilgen Ekim Üstünel, Brian Magnuson, Hugo A. Acosta-Jaquez, Jennifer A. Keller, Edward P. Feener, Diane C. Fingar · 2011 · Molecular and Cellular Biology
- Granulocyte-Macrophage Colony-Stimulating Factor Is a Chemoattractant Cytokine for Human Neutrophils: Involvement of the Ribosomal p70 S6 Kinase Signaling PathwayJulián Gómez-Cambronero, Jeffrey M. Horn, Cassandra C. Paul, Michael A Baumann · 2003 · The Journal of Immunology
- LymphangioleiomyomatosisAngelo M. Taveira‐DaSilva, Wendy K. Steagall, Joel Moss · 2006 · Cancer Control
- Rapamycin-Resistant mTORC1 Kinase Activity Is Required for Herpesvirus ReplicationNathaniel J. Moorman, Thomas E. Shenk · 2010 · Journal of Virology
- Stress-mediated translational control in cancer cellsGabriel Leprivier, Barak Rotblat, Debjit Khan, Eric Jan, Poul H. B. Sorensen · 2014 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignanciesJorge Alberto Garcia, David Danielpour · 2008 · Molecular Cancer Therapeutics
- Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscleZhe Song, Daniel R. Moore, Nathan W. Hodson, Carl Ward, Jessica R. Dent, Mary F. O’Leary, Andrew M. Shaw, David Lee Hamilton, Sovan Sarkar, Yann‐Gaël Gangloff et al. · 2017 · Scientific Reports
- Involvement of Insulin Receptor Substrate 2 in Mammary Tumor MetastasisJulie A. Nagle, Zhefu Ma, Maura A. Byrne, Morris F. White, Leslie M. Shaw · 2004 · Molecular and Cellular Biology
- Are neuroendocrine tumours a feature of tuberous sclerosis? A systematic reviewDorota Dworakowska B, Ashley Barry Grossman · 2008 · Endocrine Related Cancer
- Genetics and Molecular Biology of Tuberous Sclerosis ComplexValerio Napolioni, Paolo Curatolo · 2008 · Current Genomics
- Emerging Role of mTOR in the Response to Cancer TherapeuticsErika Ilagan, Brendan D. Manning · 2016 · Trends in cancer
- Current development of the second generation of mTOR inhibitors as anticancer agentsHongyu Zhou, Shile Huang · 2011 · 癌症:英文版
- AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signalingKelly Casey Carroll, Benoı̂t Viollet, Jill Suttles · 2013 · Journal of Leukocyte Biology
- mTOR Signaling in Parkinson’s DiseaseAiping Lan, Jun Chen, Yuliang Zhao, Zhifang Chai, Yi Hu · 2016 · NeuroMolecular Medicine
- Human Papillomavirus 16 E6 Oncoprotein Interferences with Insulin Signaling Pathway by Binding to TuberinZheming Lu, Xiuhua Hu, Yong Li, Li Zheng, Yue Zhou, Haidi Jiang, Tao Ning, Zhuoma Basang, Chunfeng Zhang, Yang Ke · 2004 · Journal of Biological Chemistry
- Tumorigenic activity and therapeutic inhibition of Rheb GTPaseKonstantinos J. Mavrakis, Hong Zhu, Ricardo L.A. Silva, John R. Mills, Julie Teruya‐Feldstein, Scott W. Lowe, Wayne Tam, Jerry Pelletier, Hans‐Guido Wendel · 2008 · Genes & Development
- Mammalian Target of Rapamycin InhibitionJanice P. Dutcher · 2004 · Clinical Cancer Research
- Analysis of mTOR signaling by the small G‐proteins, Rheb and RhebL1Andrew R. Tee, John Blenis, Christopher G. Proud · 2005 · FEBS Letters
- Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights From Genetic Mouse ModelsPolina Kosillo, Helen S. Bateup · 2021 · Frontiers in Neural Circuits