The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections
Open accessAbstract
Significance: The cGAS-STING pathway is important for immune defense against infection and cancer. STING activation triggers multiple signaling cascades leading to activation of IRF3, NF-κB, and autophagy. By generating mice harboring mutations of STING that specifically inactivate different signaling cascades, we found that ablation of IRF3 activation, which is essential for the induction of type I interferons, was not sufficient to abolish the immune defense against virus infection and cancer in mouse models. Rather, impairing the ability of STING to recruit TBK1, which is important for activating both IRF3 and NF-κB, abolished the immune defense functions of STING. These results demonstrate that the recruitment of TBK1 to STING has functions that are broader than activating IRF3 and inducing type I interferons.
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Self-citationSTING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
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BackgroundNF-κB, inflammation, immunity and cancer: coming of age
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Self-citationPhosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
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Mitochondrial control of inflammation
Marchi, S., Guilbaud, E., Tait, S. W. G., Yamazaki, T., & Galluzzi, L. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00760-x · Cited by 1,027
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances
Xu, X., Pang, Y., & Fan, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02253-4 · Cited by 800
The cGAS–STING pathway and cancer
Samson, N., & Ablasser, A. (2022) · Nature Cancer · doi:10.1038/s43018-022-00468-w · Cited by 668
The type I interferonopathies: 10 years on
Crow, Y. J., & Stetson, D. B. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00633-9 · Cited by 489
Cellular functions of cGAS-STING signaling
Chen, C., & Xu, P. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.11.001 · Cited by 451
Metadata
- Authors
- Yum, S., Li, M., Fang, Y., & Chen, Z. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2021-03-30
- Volume
- 118
- Issue
- 14
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W3151167688
- Cited by
- 566
- References
- 63
- FWCI
- 23.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yum, S., Li, M., Fang, Y., & Chen, Z. J. (2021). TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2100225118
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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