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Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase
Open accessAbstract
A crystal structure of the anaerobic Ni-Fe-S carbon monoxide dehydrogenase (CODH) from Rhodospirillum rubrum has been determined to 2.8-Å resolution. The CODH family, for which the R. rubrum enzyme is the prototype, catalyzes the biological oxidation of CO at an unusual Ni-Fe-S cluster called the C-cluster. The Ni-Fe-S C-cluster contains a mononuclear site and a four-metal cubane. Surprisingly, anomalous dispersion data suggest that the mononuclear site contains Fe and not Ni, and the four-metal cubane has the form [NiFe 3 S 4 ] and not [Fe 4 S 4 ]. The mononuclear site and the four-metal cluster are bridged by means of Cys 531 and one of the sulfides of the cube. CODH is organized as a dimer with a previously unidentified [Fe 4 S 4 ] cluster bridging the two subunits. Each monomer is comprised of three domains: a helical domain at the N terminus, an α/β (Rossmann-like) domain in the middle, and an α/β (Rossmann-like) domain at the C terminus. The helical domain contributes ligands to the bridging [Fe 4 S 4 ] cluster and another [Fe 4 S 4 ] cluster, the B-cluster, which is involved in electron transfer. The two Rossmann domains contribute ligands to the active site C-cluster. This x-ray structure provides insight into the mechanism of biological CO oxidation and has broader significance for the roles of Ni and Fe in biological systems.
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PROCHECK: a program to check the stereochemical quality of protein structures
Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889892009944 · Cited by 24,581
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Metadata
- Authors
- Drennan, C. L., Heo, J., Sintchak, M. D., Schreiter, E., & Ludden, P. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-10-02
- Volume
- 98
- Issue
- 21
- Pages
- 11973-11978
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2077936718
- Cited by
- 322
- References
- 3
- FWCI
- 23.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Drennan, C. L., Heo, J., Sintchak, M. D., Schreiter, E., & Ludden, P. W. (2001). Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.211429998
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