The rocky roots of the acetyl-CoA pathway
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Pre-biotic RAFs provided a rich variety of organic molecules from which living systems could be constructed.
“However, they would have provided a rich variety of organic molecules from which living systems could be constructed [96,97,111].”
From Opinion: The Key Steps in the Origin of Life to the Formation of the Eukaryotic Cell (2024) · cites this paper as [96]
The development of intermediate energy transfer molecules was a major innovation early in the emergence of RAFs, effectively enabling action at a distance.
“Thus, the development of intermediate energy transfer molecules was a major innovation early in the emergence of RAFs, effectively enabling action at a distance [96,111].”
From Opinion: The Key Steps in the Origin of Life to the Formation of the Eukaryotic Cell (2024) · cites this paper as [96]
The origin of life occurs within the iron-sulfide bubbles of hydrothermal vent chimneys.
“Russell and Martin, for example, developed a highly detailed model in which the origin of life occurs within the iron-sulfide bubbles of hydrothermal vent chimneys (Russell and Martin, 2004).”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Russell and Martin, 2004
Cites
Energy conservation in chemotrophic anaerobic bacteria
Thauer, R. K., Jungermann, K., & Decker, K. (1977) · Bacteriological Reviews · doi:10.1128/br.41.1.100-180.1977 · Cited by 4,146 · see citing works
An off-axis hydrothermal vent field near the Mid-Atlantic Ridge at 30° N
Party, T. A.-6. S., Kelley, D. S., Karson, J. A., Blackman, D. K., Früh-Green, G. L., Butterfield, D. A., Lilley, M. D., Olson, E. J., Schrenk, M. O., Roe, K. K., et al. (2001) · Nature · doi:10.1038/35084000 · Cited by 1,168 · see citing works
Activated Acetic Acid by Carbon Fixation on (Fe,Ni)S Under Primordial Conditions
Huber, C., & Wächtershäuser, G. (1997) · Science · doi:10.1126/science.276.5310.245 · Cited by 714 · see citing works
Pyrite Formation, the First Energy Source for Life: a Hypothesis
Wächtershäuser, G. (1988) · Systematic and Applied Microbiology · doi:10.1016/s0723-2020(88)80001-8 · Cited by 374 · see citing works
Some like it hot, but not the first biomolecules
Bada, J. L., & Lazcano, A. (2002) · Science · doi:10.1126/science.1069487 · Cited by 222 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ecological Aspects of the Distribution of Different Autotrophic CO <sub>2</sub> Fixation Pathways
Berg, I. A. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.02473-10 · Cited by 821 · see citing works
On the origin of biochemistry at an alkaline hydrothermal vent
Martin, W., & Russell, M. J. (2007) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1881 · Cited by 771 · see citing works
Self-citationAlternative Pathways of Carbon Dioxide Fixation: Insights into the Early Evolution of Life?
Fuchs, G. (2011) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102801 · Cited by 726 · see citing works
<i>Old Acetogens, New Light</i>
Drake, H. L., Gößner, A. S., & Daniel, S. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1419.016 · Cited by 578 · see citing works
Serpentinization as a source of energy at the origin of life
RUSSELL, M. J., HALL, A. J., & MARTIN, W. (2010) · Geobiology · doi:10.1111/j.1472-4669.2010.00249.x · Cited by 527 · see citing works
Self-citationThe origin of membrane bioenergetics
Lane, N., & Martin, W. F. (2012) · Cell · doi:10.1016/j.cell.2012.11.050 · Cited by 452 · see citing works
Self-citationCommercial Biomass Syngas Fermentation.
Daniell, J., Köpke, M., & Simpson, S. (2012) · Energies · doi:10.3390/en5125372 · Cited by 444 · see citing works
On the origin of genomes and cells within inorganic compartments
Koonin, E. V., & Martin, W. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.09.006 · Cited by 406 · see citing works
Self-citationHow did LUCA make a living? Chemiosmosis in the origin of life
Lane, N., Allen, J. F., & Martin, W. (2010) · BioEssays · doi:10.1002/bies.200900131 · Cited by 377 · see citing works
Self-citationThe Origin of Life in Alkaline Hydrothermal Vents
Sojo, V., Herschy, B., Whicher, A., Camprubí, E., & Lane, N. (2016) · Astrobiology · doi:10.1089/ast.2015.1406 · Cited by 341 · see citing works
Nonenzymatic Metabolic Reactions and Life’s Origins
Muchowska, K. B., Varma, S. J., & Moran, J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00191 · Cited by 317 · see citing works
The Drive to Life on Wet and Icy Worlds
Russell, M. J., Barge, L. M., Bhartia, R., Bocanegra, D., Bracher, P. J., Branscomb, E., Kidd, R., McGlynn, S., Meier, D. H., Nitschke, W., et al. (2014) · Astrobiology · doi:10.1089/ast.2013.1110 · Cited by 288 · see citing works
“, 2013); and (9) acetate, water, and nitric oxide being the first waste products (Russell and Martin, 2004; Nitschke and Russell, 2013).”
InfluentialSelf-citationBiogeochemical signatures through time as inferred from whole microbial genomes
Zerkle, A. L. (2005) · American Journal of Science · doi:10.2475/ajs.305.6-8.467 · Cited by 223 · see citing works
The last universal common ancestor between ancient Earth chemistry and the onset of genetics
Weiss, M. C., Preiner, M., Xavier, J. C., Zimorski, V., & Martin, W. F. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007518 · Cited by 186 · see citing works
Self-citationAn origin-of-life reactor to simulate alkaline hydrothermal vents
Herschy, B., Whicher, A., Camprubi, E., Watson, C., Dartnell, L., Ward, J., Evans, J. R. G., & Lane, N. (2014) · Journal of Molecular Evolution · doi:10.1007/s00239-014-9658-4 · Cited by 194 · see citing works
Marcellin, E., Behrendorff, J. B., Nagaraju, S., DeTissera, S., Segovia, S., Palfreyman, R. W., Daniell, J., Licona-Cassani, C., Quek, L.-E., Speight, R., et al. (2016) · Green Chemistry · doi:10.1039/c5gc02708j · Cited by 159 · see citing works
The Future of Origin of Life Research: Bridging Decades-Old Divisions
Preiner, M., Asche, S., Becker, S., Betts, H. C., Boniface, A., Camprubi, E., Chandru, K., Erastova, V., Garg, S. G., Khawaja, N., et al. (2020) · Life · doi:10.3390/life10030020 · Cited by 140 · see citing works
CO <sub>2</sub> reduction driven by a pH gradient
Hudson, R., de Graaf, R., Strandoo Rodin, M., Ohno, A., Lane, N., McGlynn, S. E., Yamada, Y. M. A., Nakamura, R., Barge, L. M., Braun, D., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002659117 · Cited by 158 · see citing works
Iron catalysis at the origin of life
Camprubi, E., Jordan, S. F., Vasiliadou, R., & Lane, N. (2017) · IUBMB Life · doi:10.1002/iub.1632 · Cited by 144 · see citing works
Older than genes: the acetyl CoA pathway and origins
Martin, W. F. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00817 · Cited by 132 · see citing works
Self-citationDomagal-Goldman, S. D., Wright, K. E., Domagal-Goldman, S. D., Wright, K. E., Adamala, K., Arina de la Rubia, L., Bond, J., Dartnell, L. R., Goldman, A. D., Lynch, K., et al. (2016) · Astrobiology · doi:10.1089/ast.2015.1460 · Cited by 136 · see citing works
“Russell and Martin, for example, developed a highly detailed model in which the origin of life occurs within the iron-sulfide bubbles of hydrothermal vent chimneys (Russell and Martin, 2004).”
Nitschke, W., & Russell, M. J. (2009) · Journal of Molecular Evolution · doi:10.1007/s00239-009-9289-3 · Cited by 132 · see citing works
Self-citationProton gradients at the origin of life
Lane, N. (2017) · BioEssays · doi:10.1002/bies.201600217 · Cited by 115 · see citing works
Martin, W. F. (2012) · FEBS Letters · doi:10.1016/j.febslet.2011.09.031 · Cited by 108 · see citing works
Self-citationGreen Rust: The Simple Organizing ‘Seed’ of All Life?
Russell, M. J. (2018) · Life · doi:10.3390/life8030035 · Cited by 101 · see citing works
Self-citationCoenzymes and their role in the evolution of life
Kirschning, A. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.201914786 · Cited by 107 · see citing works
A prebiotic basis for ATP as the universal energy currency
Pinna, S., Kunz, C., Halpern, A., Harrison, S. A., Jordan, S. F., Ward, J., Werner, F., & Lane, N. (2022) · PLOS Biology · doi:10.1371/journal.pbio.3001437 · Cited by 103 · see citing works
Serpentinization: connecting geochemistry, ancient metabolism and industrial hydrogenation
Preiner, M., Xavier, J. C., Sousa, F. L., Zimorski, V., Neubeck, A., Lang, S. Q., Greenwell, H. C., Kleinermanns, K., Tüysüz, H., McCollom, T. M., et al. (2018) · Life · doi:10.3390/life8040041 · Cited by 97 · see citing works
Self-citationAcetyl Phosphate as a Primordial Energy Currency at the Origin of Life
Whicher, A., Camprubi, E., Pinna, S., Herschy, B., & Lane, N. (2018) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-018-9555-8 · Cited by 81 · see citing works
Mimicking the Surface and Prebiotic Chemistry of Early Earth Using Flow Chemistry
Ritson, D. J., Battilocchio, C., Ley, S. V., & Sutherland, J. D. (2018) · Nature Communications · doi:10.1038/s41467-018-04147-2 · Cited by 89 · see citing works
A Life with Acetogens, Thermophiles, and Cellulolytic Anaerobes
Ljungdahl, L. G. (2009) · Annual Review of Microbiology · doi:10.1146/annurev.micro.091208.073617 · Cited by 73 · see citing works
Beyazay, T., Belthle, K. S., Farès, C., Preiner, M., Moran, J., Martin, W. F., & Tüysüz, H. (2023) · Nature Communications · doi:10.1038/s41467-023-36088-w · Cited by 72 · see citing works
Self-citationBranscomb, E., & Russell, M. J. (2018) · BioEssays · doi:10.1002/bies.201700182 · Cited by 59 · see citing works
Self-citationFan, J., & Papadopoulos, V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076701 · Cited by 48 · see citing works
Bioenergetic constraints on the origin of autotrophic metabolism
Boyd, E. S., Amenabar, M. J., Poudel, S., & Templeton, A. S. (2020) · Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences · doi:10.1098/rsta.2019.0151 · Cited by 46 · see citing works
Energetics of amino acid synthesis in alkaline hydrothermal environments
Kitadai, N. (2015) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-015-9428-3 · Cited by 34 · see citing works
On the free energy that drove primordial anabolism
Kaufmann, M. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10041853 · Cited by 23 · see citing works
Elucidation of an iterative process of carbon-carbon bond formation of prebiotic significance
Loison, A., Dubant, S., Adam, P., & Albrecht, P. (2010) · Astrobiology · doi:10.1089/ast.2009.0441 · Cited by 26 · see citing works
Belthle, K. S., Martin, W. F., & Tüysüz, H. (2024) · ChemCatChem · doi:10.1002/cctc.202301218 · Cited by 12 · see citing works
Self-citationBeyazay, T., Ochoa‐Hernández, C., Song, Y., Belthle, K. S., Martin, W. F., & Tüysüz, H. (2023) · Angewandte Chemie · doi:10.1002/ange.202218189 · Cited by 11 · see citing works
Self-citationOpinion: The Key Steps in the Origin of Life to the Formation of the Eukaryotic Cell
Brunk, C. F., & Marshall, C. R. (2024) · Life · doi:10.3390/life14020226 · Cited by 5 · see citing works
“Thus, the development of intermediate energy transfer molecules was a major innovation early in the emergence of RAFs, effectively enabling action at a distance [96,111].”
BackgroundInfluential
- Authors
- Russell, M. J., & Martin, W.
- Affiliations
- Scottish Universities Environmental Research Centre (GB)
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Martin, William
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 29
- Issue
- 7
- Pages
- 358-363
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2068934337
- Cited by
- 432
- References
- 5
- Citations by year
- 2026: 26 · 2025: 17 · 2024: 22 · 2023: 26 · 2022: 27 · 2021: 23 · 2020: 25 · 2019: 29 · 2018: 24 · 2017: 29 · 2016: 16 · 2015: 14 · 2014: 17 · 2013: 18 · 2012: 23
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Metalloenzymes and iron-sulfur proteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- origin of life, acetyl-CoA pathway, CO2 fixation, carbon monoxide dehydrogenase, acetyl-CoA synthase, hydrothermal vents, hydrogen as electron donor, early Earth, acetate
- MeSH terms
- Acetyl Coenzyme A, Carbon Dioxide, Geology, Sulfides, Thermodynamics, Geological Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
