The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Error catastrophe and antiviral strategy
Open accessAbstract
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
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“Selection in these systems thus does not act on the level of individual mutants, but rather on the entire quasi-species [8–10].”
From Towards open-ended evolution in self-replicating molecular systems (2017) · cites this paper as [10]
Experimental — accuracy not yet measuredIn the citing paper
“Indeed, increasing the mutation rate to precipitate an error catastrophe appears to be a practical anti-retroviral strategy (14–16).”
From The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA (2011) · cites this paper as [16]
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Citations
Cites
Selforganization of matter and the evolution of biological macromolecules
Eigen, M. (1971) · Die Naturwissenschaften · doi:10.1007/bf00623322 · Cited by 3,788
Self-citationThe Hypercycle: A principle of natural self-organization
Eigen, M., & Schuster, P. M. (1979) · Cited by 1,906
Self-citationA principle of natural self-organization: Part A: Emergence of the hypercycle
Eigen, M., & Schuster, P. (1977) · Naturwissenschaften · doi:10.1007/bf00450633 · Cited by 1,752
Self-citationEigen, M., & Schuster, P. (1979) · doi:10.1007/978-3-642-67247-7 · Cited by 949
Self-citationRNA virus error catastrophe: Direct molecular test by using ribavirin
Crotty, S., Cameron, C. E., & Andino, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111085598 · Cited by 844
The Hypercycle: A principle of natural self-organization Part B: The abstract hypercycle
Eigen, M., & Schuster, P. (1978) · Naturwissenschaften · doi:10.1007/bf00420631 · Cited by 702
Self-citationHamming, R. W. (1980) · Cited by 693
Eigen, M., McCaskill, J., & Schuster, P. (1988) · The Journal of Physical Chemistry · doi:10.1021/j100335a010 · Cited by 670
Self-citationOrigin and Evolution of Viruses
Holland, J. J., & Domingo, E. (1998) · Virus Genes · doi:10.1023/a:1007989407305 · Cited by 524
Lethal mutagenesis of HIV with mutagenic nucleoside analogs
Loeb, L. A., Essigmann, J. M., Kazazi, F., Zhang, J., Rose, K. D., & Mullins, J. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1492 · Cited by 358
Stationary mutant distributions and evolutionary optimization
Schuster, P., & Swetina, J. (1988) · Bulletin of Mathematical Biology · doi:10.1016/s0092-8240(88)80059-4 · Cited by 203
Viruses at the Edge of Adaptation
Domingo, E. (2000) · Virology · doi:10.1006/viro.2000.0320 · Cited by 174
Tarazona, P. (1992) · Physical Review A · doi:10.1103/physreva.45.6038 · Cited by 170
Grande-Pérez, A., Sierra, S., Castro, M. G., Domingo, E., & Lowenstein, P. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182426999 · Cited by 146
Eigen, M., Biebricher, C. Κ., Gebinoga, M., & Gardiner, W. C. (1991) · Biochemistry · doi:10.1021/bi00110a001 · Cited by 120
Self-citationPhysical Approaches to Biological Evolution
Volkenstein, M. V. (1994) · Springer eBooks · doi:10.1007/978-3-642-78788-1 · Cited by 80
Perspective - Lethal Mutagenesis of HIV by Mutagenic Ribonucleoside Analogs
Loeb, L. A., & Mullins, J. I. (2000) · AIDS Research and Human Retroviruses · doi:10.1089/088922200309539 · Cited by 70
How old is the immunodeficiency virus?
Eigen, M., & Nieselt-Struwe, K. (1990) · AIDS · doi:10.1097/00002030-199001001-00014 · Cited by 46
Self-citationThe Immune System in Vertical HIV Infection: The Immune Response and Disease Progression
Paul, M. E. (1997) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1997.13.1 · Cited by 24
The fifth Paul Ehrlich lecture virus strains as models of molecular evolution
Eigen, M. (1993) · Medicinal Research Reviews · doi:10.1002/med.2610130402 · Cited by 8
Self-citation
Research works printed but not linked: 4
- Kimura M. & Ohta T. (1971) Population Genetics (Princeton Univ. Press Princeton NJ).
- Eigen M., McCaskill, J. & Schuster, P. (1989) Adv. Chem. Phys.75,149-263.
- 10.1007/BF02460094 · DOI
- Gebinoga M. (1991) Ph.D. thesis (Technical University of Braunschweig Braunschweig Germany).
Cited by
Sorted by citations
Domingo, E., Sheldon, J., & Perales, C. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05023-11 · Cited by 1,009
Quasispecies Theory and the Behavior of RNA Viruses
Lauring, A. S., & Andino, R. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001005 · Cited by 888
de Miranda, J. R., & Genersch, E. (2009) · Journal of Invertebrate Pathology · doi:10.1016/j.jip.2009.06.012 · Cited by 555
Colloquium : Criticality and dynamical scaling in living systems
Muñoz, M. A. (2018) · Reviews of Modern Physics · doi:10.1103/revmodphys.90.031001 · Cited by 556
Cancer as a robust system: implications for anticancer therapy
Kitano, H. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1300 · Cited by 456
Metadata
- Authors
- Eigen, M.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Eigen, Manfred
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-10-07
- Volume
- 99
- Issue
- 21
- Pages
- 13374-13376
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC129678
- OpenAlex
- W1981105411
- Cited by
- 339
- References
- 19
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 10 · 2019: 15 · 2018: 12 · 2017: 11 · 2016: 12 · 2015: 20 · 2014: 19 · 2013: 14 · 2012: 25
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Mathematics › Applied Mathematics › Mathematical and Theoretical Epidemiology and Ecology Models
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- error catastrophe, antiviral strategies, viral replication, error threshold, viral quasispecies
- MeSH terms
- Antiviral Agents, DNA Replication, Models, Biological, Mutation, Virus Replication, Viruses, Virus Physiological Phenomena
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