Cited by 339Evolution and Genetic DynamicsMathematical and Theoretical Epidemiology and Ecology ModelsRNA and protein synthesis mechanisms

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Error catastrophe and antiviral strategy

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Eigen, Manfred·2002·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.212514799PMC PMC129678

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Selforganization of matter and the evolution of biological macromolecules
Eigen, M. (1971) · Die Naturwissenschaften · doi:10.1007/bf00623322 · Cited by 3,788
Self-citation
The Hypercycle: A principle of natural self-organization
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Eigen, M., & Schuster, P. (1977) · Naturwissenschaften · doi:10.1007/bf00450633 · Cited by 1,752
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Crotty, S., Cameron, C. E., & Andino, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111085598 · Cited by 844
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Coding and Information Theory
Hamming, R. W. (1980) · Cited by 693
Molecular quasi-species
Eigen, M., McCaskill, J., & Schuster, P. (1988) · The Journal of Physical Chemistry · doi:10.1021/j100335a010 · Cited by 670
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Origin and Evolution of Viruses
Holland, J. J., & Domingo, E. (1998) · Virus Genes · doi:10.1023/a:1007989407305 · Cited by 524
Lethal mutagenesis of HIV with mutagenic nucleoside analogs
Loeb, L. A., Essigmann, J. M., Kazazi, F., Zhang, J., Rose, K. D., & Mullins, J. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1492 · Cited by 358

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Research works printed but not linked: 4

Kimura M. & Ohta T. (1971) Population Genetics (Princeton Univ. Press Princeton NJ).
Eigen M., McCaskill, J. & Schuster, P. (1989) Adv. Chem. Phys.75,149-263.
10.1007/BF02460094 · DOI
Gebinoga M. (1991) Ph.D. thesis (Technical University of Braunschweig Braunschweig Germany).

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Viral Quasispecies: Dynamics, Interactions, and Pathogenesis**Dedicated to Manfred Eigen on the occasion of his 80th birthday, for the insights that his pioneer studies have represented for virology.
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Authors: Eigen, M.
Affiliations: Max Planck Society (DE)
Corresponding author: Eigen, Manfred
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2002-10-07
Volume: 99
Issue: 21
Pages: 13374-13376
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.212514799
PMC: PMC129678
OpenAlex: W1981105411
Cited by: 339
References: 19
Citations by year: 2026: 6 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 10 · 2019: 15 · 2018: 12 · 2017: 11 · 2016: 12 · 2015: 20 · 2014: 19 · 2013: 14 · 2012: 25
FWCI: 7.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Physical Sciences › Mathematics › Applied Mathematics › Mathematical and Theoretical Epidemiology and Ecology Models
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: error catastrophe, antiviral strategies, viral replication, error threshold, viral quasispecies
MeSH terms: Antiviral Agents, DNA Replication, Models, Biological, Mutation, Virus Replication, Viruses, Virus Physiological Phenomena

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