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Cited by 670Origins and Evolution of LifeEvolution and Genetic DynamicsRNA and protein synthesis mechanisms

Molecular quasi-species

Eigen, Manfred, McCaskill, John, Schuster, Peter·1988·The Journal of Physical Chemistry
DOI 10.1021/j100335a010
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Abstract

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular quasi-speciesManfred Eigen, John McCaskill, and Peter SchusterCite this: J. Phys. Chem. 1988, 92, 24, 6881–6891Publication Date (Print):December 1, 1988Publication History Published online1 May 2002Published inissue 1 December 1988https://pubs.acs.org/doi/10.1021/j100335a010https://doi.org/10.1021/j100335a010research-articleACS PublicationsRequest reuse permissionsArticle Views1524Altmetric-Citations433LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts

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  • For relatively high mutation rates, not a single fittest replicator but rather a distribution of closely related mutants survives.

    “This concept captures the fact that for relatively high mutation rates not a single fittest replicator, but rather a distribution of closely related mutants survives.”

    From Towards open-ended evolution in self-replicating molecular systems (2017) · cites this paper as [8]

  • Unless mutation rates are significantly diminished, an increase in genome length unavoidably leads to a catastrophic loss of hereditary information.

    “In the same work, Eigen showed that unless mutation rates were significantly diminished, the increase in the length of the genome would unavoidably lead to a catastrophic loss of hereditary information.”

    From Towards open-ended evolution in self-replicating molecular systems (2017) · cites this paper as [8]

  • If the replication error rate exceeds a certain error threshold, genetic information will disintegrate and the species will go extinct.

    “If the rate at which errors in the replication occur exceeds a certain error threshold, the genetic information will disintegrate and the species will go extinct [8,12].”

    From Towards open-ended evolution in self-replicating molecular systems (2017) · cites this paper as [8]

  • Selection in quasi-species systems acts on the entire quasi-species, not on individual mutants.

    “Selection in these systems thus does not act on the level of individual mutants, but rather on the entire quasi-species [8–10].”

    From Towards open-ended evolution in self-replicating molecular systems (2017) · cites this paper as [8]

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Sorted by citations

Authors
Eigen, M., McCaskill, J., & Schuster, P.
Affiliations
Max Planck Society (DE)
ORCID
Venue
The Journal of Physical Chemistry
Publisher
American Chemical Society (ACS)
Published
1988-12
Volume
92
Issue
24
Pages
6881-6891
ISSN
  • 0022-3654 (ISSN-L)
  • 1541-5740
DOI
10.1021/j100335a010
OpenAlex
W2045979783
Cited by
670
References
0
Citations by year
2026: 12 · 2025: 8 · 2024: 13 · 2023: 16 · 2022: 16 · 2021: 21 · 2020: 21 · 2019: 18 · 2018: 30 · 2017: 23 · 2016: 19 · 2015: 16 · 2014: 19 · 2013: 27 · 2012: 33
FWCI
14.62
Type
journal article
Language
en
Open access
closed
Locations
The Journal of Physical Chemistry (publishedVersion)
Funders
Max-Planck-Gesellschaft
Topics
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
error catastrophe, error threshold, population dynamics, sequence spaces, mutation-selection balance, molecular evolution

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