Cancer as a robust system: implications for anticancer therapy
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Acquired drug resistance is the major cause of chemotherapy-based cancer treatment failure.
“Acquired drug resistance is the major cause of chemotherapy-based cancer treatment failure [129, 130].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [129]
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Power law distribution of chromosome aberrations in cancer.
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Extensive cytogenetic heterogeneity in a benign retroperitoneal schwannoma
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Flagged first, then by citations
Cited by
Sorted by citations
Kitano, H. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1471 · Cited by 2,278 · see citing works
Self-citationRobustness of cellular functions
Stelling, J., Sauer, U., Szallasi, Z., Doyle, F. J., & Doyle, J. (2004) · Cell · doi:10.1016/j.cell.2004.09.008 · Cited by 1,049 · see citing works
A robustness-based approach to systems-oriented drug design
Kitano, H. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2195 · Cited by 488 · see citing works
Self-citationNon-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities
Li, L., Hu, S., & Chen, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.031 · Cited by 415 · see citing works
Cell fate decision mediated by p53 pulses
Zhang, X.-P., Liu, F., Cheng, Z., & Wang, W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813088106 · Cited by 253 · see citing works
Novel aspects of oxidative stress-associated carcinogenesis
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Role of mitochondrial uncoupling protein 2 in cancer cell resistance to gemcitabine
Dalla Pozza, E., Fiorini, C., Dando, I., Menegazzi, M., Sgarbossa, A., Costanzo, C., Palmieri, M., & Donadelli, M. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.06.007 · Cited by 84 · see citing works
Albers, J., Markus, A., Svetlove, A., Kraupner, A., Briel, A., Alves, F., & Dullin, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-02560-4 · Cited by 3 · see citing works
- Authors
- Kitano, H.
- Affiliations
- Sony Computer Science Laboratories (JP)
- Corresponding author
- Kitano, Hiroaki
- ORCID
- Kitano, Hiroaki
- Venue
- Nature reviews. Cancer
- Published
- 2004-03
- Volume
- 4
- Issue
- 3
- Pages
- 227-235
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1541316156
- Cited by
- 456
- References
- 130
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 7 · 2023: 9 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 16 · 2018: 18 · 2017: 17 · 2016: 29 · 2015: 20 · 2014: 28 · 2013: 31 · 2012: 30
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Science and Technology Agency
- Exploratory Research for Advanced Technology
- Air Force Office of Scientific Research
- Topics
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- tumor heterogeneity, cancer therapy, cancer systems biology, treatment resistance
- MeSH terms
- Antineoplastic Agents, Humans, Models, Biological, Neoplasms, Drug Design
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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