Selection of Nucleic Acid Aptamers Targeting Tumor Cell-Surface Protein Biomarkers

Mercier, Marie-Cécile; Dontenwill, Monique; Choulier, Laurence

doi:10.3390/cancers9060069

Cited by 113Advanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryDNA and Nucleic Acid Chemistry

Selection of Nucleic Acid Aptamers Targeting Tumor Cell-Surface Protein Biomarkers

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Mercier, Marie-Cécile, Dontenwill, Monique, Choulier, Laurence·2017·Cancers

DOI 10.3390/cancers9060069PMC PMC5483888

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Abstract

Aptamers are nucleic acids referred to as chemical antibodies as they bind to their specific targets with high affinity and selectivity. They are selected via an iterative process known as ‘selective evolution of ligands by exponential enrichment’ (SELEX). Aptamers have been developed against numerous cancer targets and among them, many tumor cell-membrane protein biomarkers. The identification of aptamers targeting cell-surface proteins has mainly been performed by two different strategies: protein- and cell-based SELEX, when the targets used for selection were proteins and cells, respectively. This review aims to update the literature on aptamers targeting tumor cell surface protein biomarkers, highlighting potentials, pitfalls of protein- and cell-based selection processes and applications of such selected molecules. Aptamers as promising agents for diagnosis and therapeutic approaches in oncology are documented, as well as aptamers in clinical development.

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Nucleic acid aptamers are single-stranded oligonucleotides that fold into unique tertiary structures to identify targets.
“Nucleic acid aptamers are single-stranded oligonucleotides (ssDNA or ssRNA), which can be folded into a unique tertiary structure to identify its target.237”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [237]

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Cancer immunotherapy via nucleic acid aptamers
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Aptamer for imaging and therapeutic targeting of brain tumor glioblastoma
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2′,4′-BNA/LNA aptamers: CE-SELEX using a DNA-based library of full-length 2′-O,4′-C-methylene-bridged/linked bicyclic ribonucleotides
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Aptamers: Molecular Tools for Medical Diagnosis
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Towards the selection of phosphorothioate aptamers
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Randomized phase II trial of the nucleolin targeting aptamer AS1411 combined with high-dose cytarabine in relapsed/refractory acute myeloid leukemia (AML)
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Knocking down nucleolin expression in gliomas inhibits tumor growth and induces cell cycle arrest
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Selection of Aptamers Against Whole Living Cells: From Cell-SELEX to Identification of Biomarkers
Quang, N. N., Miodek, A., Cibiel, A., & Ducongè, F. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6857-2_16 · Cited by 48 · see citing works
Pitfalls of Cell-Systematic Evolution of Ligands by Exponential Enrichment (SELEX): Existing Dead Cells During In Vitro Selection Anticipate the Enrichment of Specific Aptamers
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Aptamers Selected by Cell-SELEX for Theranostics
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From Ugly Duckling to Swan: Unexpected Identification from Cell-SELEX of an Anti-Annexin A2 Aptamer Targeting Tumors
Cibiel, A., Quang, N. N., Gombert, K., Thezé, B., Garofalakis, A., & Ducongè, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087002 · Cited by 45 · see citing works
RNA Aptamer-Based Functional Ligands of the Neurotrophin Receptor, TrkB
Huang, Y. Z., Hernández, F. J., Gu, B., Stockdale, K. R., Nanapaneni, K., Scheetz, T. E., Behlke, M. A., Peek, A. S., Bair, T., Giangrande, P. H., et al. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.078220 · Cited by 43 · see citing works
Generation of an enriched pool of DNA aptamers for an HER2‐overexpressing cell line selected by Cell SELEX
Dastjerdi, K., Tabar, G. H., Dehghani, H., & Haghparast, A. (2011) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.36 · Cited by 42 · see citing works
Ligand-guided selection of aptamers against T-cell Receptor-cluster of differentiation 3 (TCR-CD3) expressed on Jurkat.E6 cells
Zümrüt, H. E., Ara, M. N., Maio, G. E., Van, N. A., Batool, S., & Mallikaratchy, P. R. (2016) · Analytical Biochemistry · doi:10.1016/j.ab.2016.08.007 · Cited by 42 · see citing works
Metastasis‐focused cell‐based SELEX generates aptamers inhibiting cell migration and invasion
Zueva, E., Rubio, L. I., Ducongè, F., & Tavitian, B. (2010) · International Journal of Cancer · doi:10.1002/ijc.25401 · Cited by 41 · see citing works
Identification of RNA aptamers that internalize into HPV-16 E6/E7 transformed tonsillar epithelial cells
Gourronc, F. A., Rockey, W. M., Thiel, W. H., Giangrande, P. H., & Klingelhutz, A. J. (2013) · Virology · doi:10.1016/j.virol.2013.08.015 · Cited by 41 · see citing works
SELEX Aptamer Used as a Probe to Detect Circulating Tumor Cells in Peripheral Blood of Pancreatic Cancer Patients
Zhang, J., Li, S., Liu, F., Zhou, L., Shao, N., & Zhao, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121920 · Cited by 41 · see citing works
A cell-based single-stranded DNA aptamer specifically targets gastric cancer
Zhang, X., Zhang, J., Ma, Y., Pei, X., Liu, Q., Lü, B., Li, J., Wang, J., & Liu, J. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.10.006 · Cited by 41 · see citing works
Selection of DNA aptamers for extra cellular domain of human epidermal growth factor receptor 2 to detect HER2 positive carcinomas
Sett, A., Borthakur, B. B., & Bora, U. (2017) · Clinical & Translational Oncology · doi:10.1007/s12094-017-1629-y · Cited by 41 · see citing works
Targeted delivery of Epirubicin to cancer cells by PEGylated A10 aptamer
Taghdisi, S. M., Danesh, N. M., Emrani, A. S., Tabrizian, K., Zandkarimi, M., Ramezani, M., & Abnous, K. (2013) · Journal of drug targeting · doi:10.3109/1061186x.2013.812095 · Cited by 40 · see citing works
Selection and Characterization of an α6β4 Integrin blocking DNA Aptamer
Berg, K., Lange, T., Mittelberger, F., Schumacher, U., & Hahn, U. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2016.10 · Cited by 39 · see citing works
Targeting Insulin Receptor with a Novel Internalizing Aptamer
Iaboni, M., Fontanella, R., Rienzo, A., Capuozzo, M., Nuzzo, S., Santamaria, G., Catuogno, S., Condorelli, G., de Franciscis, V., & Esposito, C. L. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2016.73 · Cited by 39 · see citing works
DNA Aptamer Based Nanodrugs: Molecular Engineering for Efficiency
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Aptamers Against Cell Surface Receptors: Selection, Modification and Application
Wang, J., & Li, G. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711797189628 · Cited by 37 · see citing works
Aptamers: A Feasible Technology in Cancer Immunotherapy
Soldevilla, M. M., Villanueva, H., & Pastor, F. (2016) · Journal of Immunology Research · doi:10.1155/2016/1083738 · Cited by 37 · see citing works
Aptamers and Their Significant Role in Cancer Therapy and Diagnosis
Prakash, J. J. S., & Rajamanickam, K. (2015) · Biomedicines · doi:10.3390/biomedicines3030248 · Cited by 36 · see citing works
Update on the first phase I study of AGRO100 in advanced cancer
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ErbB Family Signalling: A Paradigm for Oncogene Addiction and Personalized Oncology
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Aptamers: A New Technological Platform in Cancer Immunotherapy
Pastor, F. (2016) · Pharmaceuticals · doi:10.3390/ph9040064 · Cited by 33 · see citing works
The efficient cell-SELEX strategy, Icell-SELEX, using isogenic cell lines for selection and counter-selection to generate RNA aptamers to cell surface proteins
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Cell Internalization SELEX: In Vitro Selection for Molecules That Internalize into Cells
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Aptamer-Functionalized Nanoparticles for Drug Delivery
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Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Aptamer-Based Detection of Circulating Targets for Precision Medicine
Wu, L., Wang, Y., Xu, X., Liu, Y., Lin, B., Zhang, M., Zhang, J., Wan, S., Yang, C. J., & Tan, W. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01140 · Cited by 704 · see citing works
Recent Advances in Aptamer Discovery and Applications
Zhang, Y., Lai, B. S., & Juhas, M. (2019) · Molecules · doi:10.3390/molecules24050941 · Cited by 670 · see citing works
Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development
Wang, T., Chen, C., Larcher, L. M., Barrero, R. A., & Veedu, R. N. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.11.001 · Cited by 531 · see citing works
Perspective on the Future Role of Aptamers in Analytical Chemistry
Wu, Y., Belmonte, I., Sykes, K. S., Xiao, Y., & White, R. J. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03853 · Cited by 173 · see citing works
Cancer stem cells-emanated therapy resistance: Implications for liposomal drug delivery systems
Dianat-Moghadam, H., Heidarifard, M., Jahanban-Esfahlan, R., Panahi, Y., Hamishehkar, H., Pouremamali, F., Rahbarghazi, R., & Nouri, M. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.08.043 · Cited by 140 · see citing works
Recent developments in cell-SELEX technology for aptamer selection
Kaur, H. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.07.029 · Cited by 128 · see citing works
Advances in the development of fluorescence probes for cell plasma membrane imaging
Liu, C., Gao, X., Yuan, J., & Zhang, R. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116092 · Cited by 120 · see citing works
The research of aptamer biosensor technologies for detection of microorganism
Yi, J., Xiao, W., Li, G., Wu, P., He, Y., Chen, C., He, Y., Ding, P., & Kai, T. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10940-1 · Cited by 109 · see citing works
Electrochemical biosensors based on polymer nanocomposites for detecting breast cancer: Recent progress and future prospects
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Development of a fluorescence aptasensor for rapid and sensitive detection of Listeria monocytogenes in food
Liu, R., Zhang, Y., Ali, S., Haruna, S. A., He, P., Li, H., Ouyang, Q., & Chen, Q. (2020) · Food Control · doi:10.1016/j.foodcont.2020.107808 · Cited by 97 · see citing works
Fluorescence Sensing Using DNA Aptamers in Cancer Research and Clinical Diagnostics
Musumeci, D., Platella, C., Riccardi, C., Moccia, F., & Montesarchio, D. (2017) · Cancers · doi:10.3390/cancers9120174 · Cited by 95 · see citing works
Application of aptamers for in vivo molecular imaging and theranostics
Bouvier‐Müller, A., & Ducongè, F. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.08.004 · Cited by 89 · see citing works
Development of Phosphorothioate DNA and DNA Thioaptamers
Volk, D. E., & Lokesh, G. L.-R. (2017) · Biomedicines · doi:10.3390/biomedicines5030041 · Cited by 83 · see citing works
Role of Integrins in Resistance to Therapies Targeting Growth Factor Receptors in Cancer
Silva, E. C. D., Dontenwill, M., Choulier, L., & Lehmann, M. (2019) · Cancers · doi:10.3390/cancers11050692 · Cited by 81 · see citing works
Self-citation
Chloroquine in combination with aptamer-modified nanocomplexes for tumor vessel normalization and efficient erlotinib/Survivin shRNA co-delivery to overcome drug resistance in EGFR-mutated non-small cell lung cancer
Lv, T., Li, Z., Xu, L., Zhang, Y., Chen, H., & Gao, Y. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.06.034 · Cited by 74 · see citing works
Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer
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Multifunctional polymeric micellar nanomedicine in the diagnosis and treatment of cancer
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Aptamer-Based Liquid Biopsy
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Aptamer-Based Point-of-Care Devices: Emerging Technologies and Integration of Computational Methods
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Biological Relevance of RGD‐Integrin Subtype‐Specific Ligands in Cancer
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The Discovery of RNA Aptamers that Selectively Bind Glioblastoma Stem Cells
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Computational Frontiers in Aptamer-Based Nanomedicine for Precision Therapeutics: A Comprehensive Review
Kumar, S., Mohan, A., Sharma, N. R., Kumar, A., Girdhar, M., Malik, T., & Verma, A. K. (2024) · ACS Omega · doi:10.1021/acsomega.4c02466 · Cited by 55 · see citing works
Bispecific therapeutic aptamers for targeted therapy of cancer: a review on cellular perspective
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Aptamer-based lateral flow assays
Schüling, T., Institut für Technische Chemie, L. U. H., Eilers, A., Scheper, T. H., & Walter, J. (2018) · AIMS bioengineering · doi:10.3934/bioeng.2018.2.78 · Cited by 51 · see citing works
Anti-PD-L1 DNA aptamer antagonizes the interaction of PD-1/PD-L1 with antitumor effect
Gao, T., Mao, Z., Li, W., & Pei, R. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01668c · Cited by 52 · see citing works
Applications of electrochemical biosensor of aptamers-based (APTASENSOR) for the detection of leukemia biomarker
Nur, Y., Gaffar, S., Hartati, Y. W., & Subroto, T. (2021) · Sensing and Bio-Sensing Research · doi:10.1016/j.sbsr.2021.100416 · Cited by 50 · see citing works
Oligonucleotide aptamers against tyrosine kinase receptors: Prospect for anticancer applications
Camorani, S., Crescenzi, E., Fedele, M., & Cerchia, L. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.03.003 · Cited by 48 · see citing works
Profiling Cancer Cells by Cell-SELEX: Use of Aptamers for Discovery of Actionable Biomarkers and Therapeutic Applications Thereof
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RNA Aptamers Targeting Integrin α5β1 as Probes for Cyto- and Histofluorescence in Glioblastoma
Fechter, P., Silva, E. C. D., Mercier, M.-C., Noulet, F., Étienne-Selloum, N., Guénot, D., Lehmann, M., Vauchelles, R., Martin, S., Lelong-Rebel, I. H., et al. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.05.006 · Cited by 45 · see citing works
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Monoclonal Antibodies Application in Lateral Flow Immunochromatographic Assays for Drugs of Abuse Detection
Qriouet, Z., Cherrah, Y., Sefrioui, H., & Qmichou, Z. (2021) · Molecules · doi:10.3390/molecules26041058 · Cited by 45 · see citing works
Aptamers: novelty tools for cancer biology
Pereira, R. L., Nascimento, I. C., Santos, A. P. D. J., Ogusuku, I. E. Y., Lameu, C., Mayer, G., & Ulrich, H. (2018) · Oncotarget · doi:10.18632/oncotarget.25260 · Cited by 44 · see citing works
An overview on the development of different optical sensing platforms for adenosine triphosphate (ATP) recognition
Sivagnanam, S., Mahato, P., & Das, P. (2023) · Organic & Biomolecular Chemistry · doi:10.1039/d3ob00209h · Cited by 42 · see citing works
Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth
Bai, C., Gao, S., Hu, S., Liu, X., Li, H., Dong, J., Huang, A., Zhu, L., Zhou, P., Li, S., et al. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.03.002 · Cited by 42 · see citing works
Development of Cell-Specific Aptamers: Recent Advances and Insight into the Selection Procedures
Rahimizadeh, K., Shamaileh, H. A., Fratini, M., Chakravarthy, M., Stephen, M. W., Shigdar, S. L., & Veedu, R. N. (2017) · Molecules · doi:10.3390/molecules22122070 · Cited by 41 · see citing works
Toward the Selection of Cell Targeting Aptamers with Extended Biological Functionalities to Facilitate Endosomal Escape of Cargoes
Tawiah, K. D., Porciani, D., & Burke, D. H. (2017) · Biomedicines · doi:10.3390/biomedicines5030051 · Cited by 40 · see citing works
Molecular Recognition and In-Vitro-Targeted Inhibition of Renal Cell Carcinoma Using a DNA Aptamer
Zhang, H., Wang, Z., Xie, L. Y., Zhang, Y., Deng, T., Li, J., Liu, J., Xiong, W., Zhang, L., Zhang, L., et al. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.07.015 · Cited by 39 · see citing works
Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment
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The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer
Roy, D., Pascher, A., Juratli, M. A., & Sporn, J. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115601 · Cited by 37 · see citing works
Detection of Breast Cancer Cells Using Acoustics Aptasensor Specific to HER2 Receptors
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Sgc8 aptamer targeted glutathione-responsive nanoassemblies containing Ara-C prodrug for the treatment of acute lymphoblastic leukemia
Fang, Z., Wang, X., Sun, Y., Fan, R., Liu, Z., Guo, R., & Xie, D. (2019) · Nanoscale · doi:10.1039/c9nr07391d · Cited by 33 · see citing works
Fluorescent aptasensor for detection of four tetracycline veterinary drugs in milk based on catalytic hairpin assembly reaction and displacement of G-quadruplex
Zhou, C., Zou, H., Sun, C., Ren, D., Xiong, W., & Li, Y. (2018) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-018-0981-2 · Cited by 33 · see citing works
Delivery systems exploiting natural cell transport processes of macromolecules for intracellular targeting of Auger electron emitters
Rosenkranz, A. A., Slastnikova, T. A., Georgiev, G. P., Zalutsky, M. R., & Sobolev, A. S. (2019) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2019.11.005 · Cited by 33 · see citing works
Aptamers in neuro-oncology: An emerging therapeutic modality
Doherty, C. L., Wilbanks, B. A., Khatua, S., & Maher, L. J., III (2023) · Neuro-Oncology · doi:10.1093/neuonc/noad156 · Cited by 32 · see citing works
Emerging Combination of Hydrogel and Electrochemical Biosensors
Huang, L., Zhou, Y., Hu, X., & Yáng, Z. (2024) · Small · doi:10.1002/smll.202409711 · Cited by 32 · see citing works
Rapid identification of specific DNA aptamers precisely targeting CD33 positive leukemia cells through a paired cell-based approach
Yang, C., Wang, Y., Ge, M. H., Fu, Y. J., Hao, R., Islam, K., Huang, P. C., Chen, F., Sun, J., Hong, D. F., et al. (2018) · Biomaterials Science · doi:10.1039/c8bm01393d · Cited by 32 · see citing works
Aptamer nucleotide analog drug conjugates in the targeting therapy of cancers
Li, Y., Zhao, J., Xue, Z., Tsang, C., Qiao, X., Dong, L., Li, H., Yang, Y., Yu, B., & Gao, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1053984 · Cited by 31 · see citing works
Aptamers in cancer therapy: problems and new breakthroughs
Jin, B., Guo, Z., Chen, Z., Chen, H., Li, S., Deng, Y., Jin, L. J., Liu, Y., Zhang, Y., & He, N. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02579e · Cited by 31 · see citing works
Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation
Esposito, C. L., Autiero, I., Sandomenico, A., Li, H., Bassal, M. A., Ibba, M. L., Wang, D., Rinaldi, L., Ummarino, S., Gaggi, G., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-35222-4 · Cited by 30 · see citing works
Aptamer-based approaches in leukemia: a paradigm shift in targeted therapy
Bayani, A., Abosaoda, M. K., Rizaev, J. A., Nazari, M., Jafari, Z., & Samarkhazan, H. S. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01724-w · Cited by 29 · see citing works
Electrochemically synthesized polyanine@Cu-BTC MOF as a bifunctional matrix for aptasensing of tetracycline in aquatic products
Zhan, F., Zhao, Y., Dai, X., Zeng, J., & Wang, Q. (2023) · Microchemical Journal · doi:10.1016/j.microc.2023.109512 · Cited by 28 · see citing works
The protean world of non-coding RNAs in glioblastoma
Paulmurugan, R., Malhotra, M., & Massoud, T. F. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01798-6 · Cited by 25 · see citing works
Improving Breast Cancer Treatment Specificity Using Aptamers Obtained by 3D Cell-SELEX
Nelissen, F. H. T., Peeters, W. J. M., Roelofs, T. P., Nagelkerke, A., Span, P. N., & Heus, H. A. (2021) · Pharmaceuticals · doi:10.3390/ph14040349 · Cited by 25 · see citing works
Aptamer Technologies in Neuroscience, Neuro-Diagnostics and Neuro-Medicine Development
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Authors: Mercier, M.-C., Dontenwill, M., & Choulier, L.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Choulier, Laurence
ORCID: Dontenwill, Monique
Choulier, Laurence
Venue: Cancers
Publisher: MDPI AG
Published: 2017-06-21
Volume: 9
Issue: 6
Pages: 69
ISSN: 2072-6694 (ISSN-L)
DOI: 10.3390/cancers9060069
PMC: PMC5483888
OpenAlex: W2721117256
Cited by: 113
References: 233
Citations by year: 2026: 7 · 2025: 8 · 2024: 8 · 2023: 17 · 2022: 7 · 2021: 11 · 2020: 15 · 2019: 15 · 2018: 20 · 2017: 5
FWCI: 1.41
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Cancers (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Funders: Agence Nationale de la Recherche (ANR-10-SATT-0001)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: aptamers, SELEX, cancer diagnosis, cancer therapeutics

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Selection of Nucleic Acid Aptamers Targeting Tumor Cell-Surface Protein Biomarkers

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