Cited by 350Redox biology and oxidative stressNitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

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Proteomic method identifies proteins nitrated in vivo during inflammatory challenge

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Aulak, Kulwant S., Miyagi, Masaru, Yan, Lin, West, Karen A., Massillon, Duna, Crabb, John W., Stuehr, Dennis J.·2001·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.221269198PMC PMC59826

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Abstract

Inflammation in asthma, sepsis, transplant rejection, and many neurodegenerative diseases associates an up-regulation of NO synthesis with increased protein nitration at tyrosine. Nitration can cause protein dysfunction and is implicated in pathogenesis, but few proteins that appear nitrated in vivo have been identified. To understand how this modification impacts physiology and disease, we used a proteomic approach toward targets of protein nitration in both in vivo and cell culture inflammatory disease models. This approach identified more than 40 nitrotyrosine-immunopositive proteins, including 30 not previously identified, that became modified as a consequence of the inflammatory response. These targets include proteins involved in oxidative stress, apoptosis, ATP production, and other metabolic functions. Our approach provides a means toward obtaining a comprehensive view of the nitroproteome and promises to broaden understanding of how NO regulates cellular processes.

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Authors: Aulak, K. S., Miyagi, M., Yan, L., West, K. A., Massillon, D., Crabb, J. W., & Stuehr, D. J.
Affiliations: Cleveland Clinic (US)
ORCID: Aulak, Kulwant S.
Miyagi, Masaru
Stuehr, Dennis J.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2001-10-02
Volume: 98
Issue: 21
Pages: 12056-12061
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.221269198
PMC: PMC59826
OpenAlex: W1980805550
Cited by: 350
References: 51
Citations by year: 2026: 2 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 1 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 9 · 2016: 13 · 2015: 8 · 2014: 14 · 2013: 12 · 2012: 14
FWCI: 10.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
Cleveland Clinic
Cleveland Clinic Foundation
National Institutes of Health (5r21ns041644-02, CA53914, EY06603)
National Eye Institute (EY06603, F32EY006603, R01EY006603)
National Cancer Institute (CA-53914, R01CA053914)
National Institute of General Medical Sciences (GM51491, R01GM051491)
National Institute of Neurological Disorders and Stroke (NS41644)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: protein nitration, nitrotyrosine, nitric oxide, inflammation, oxidative stress, apoptosis, ATP production, metabolic proteins, asthma, sepsis, graft rejection, neurodegenerative diseases
MeSH terms: Animals, Humans, Interferon-gamma, Interleukin-1, Nitrates, Nitric Oxide, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Electrophoresis, Gel, Two-Dimensional, Gene Expression, Rats, Sprague-Dawley, Nitric Oxide Synthase, Proteome, Rats, Nitric Oxide Synthase Type II

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Proteomic method identifies proteins nitrated in vivo during inflammatory challenge

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