Stuehr, Dennis J.

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells

Stuehr, D. J., & Nathan, C. F. (1989) · The Journal of Experimental Medicine

Immune cells in cancerNitric Oxide and Endothelin Effects

Cited by 1,744

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

Stuehr, D. J., & Marletta, M. A. (1985) · Proceedings of the National Academy of Sciences

Immune Response and InflammationNitric Oxide and Endothelin Effects

Cited by 1,126

Function of Mitochondrial Stat3 in Cellular Respiration

Wegrzyn, J., Potla, R., Chwae, Y.-J., Sepuri, N. B. V., Zhang, Q., Koeck, T., Derecka, M., Szczepanek, K., Szelag, M., Gornicka, A., et al. (2009) · Science

Mitochondrial Function and PathologyCytokine Signaling Pathways and Interactions

Cited by 1,014

Mammalian nitric oxide synthases

Stuehr, D. J. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Nitric Oxide and Endothelin EffectsHemoglobin structure and function

Cited by 996

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. F., & Nathan, C. F. (1991) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 816

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

Kwon, N. S., Nathan, C. F., & Stuehr, D. J. (1989) · Journal of Biological Chemistry

Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 570

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide

Stuehr, D. J., Gross, S. S., Sakuma, I., Levi, R., & Nathan, C. F. (1989) · The Journal of experimental medicine

Nitric Oxide and Endothelin EffectsImmune cells in cancer

Cited by 457

Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.

Baek, K. J., Thiel, B. A., Lucas, S., & Stuehr, D. J. (1993) · Journal of Biological Chemistry

Nitric Oxide and Endothelin EffectsHemoglobin structure and function

Cited by 389

Proteomic method identifies proteins nitrated in vivo during inflammatory challenge

Aulak, K. S., Miyagi, M., Yan, L., West, K. A., Massillon, D., Crabb, J. W., & Stuehr, D. J. (2001) · Proceedings of the National Academy of Sciences

Redox biology and oxidative stressNitric Oxide and Endothelin Effects

Cited by 350

Modulation of Nitrogen Oxide Synthesis In Vivo: NG-Monomethyl-L-Arginine Inhibits Endotoxin-Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

Billiar, T. R., Curran, R. D., Harbrecht, B. G., Stuehr, D. J., Demetris, A. J., & Simmons, R. L. (1990) · Journal of Leukocyte Biology

Nitric Oxide and Endothelin EffectsDrug-Induced Hepatotoxicity and Protection

Cited by 335

Arginine Conversion to Nitroxide by Tetrahydrobiopterin-free Neuronal Nitric-oxide Synthase

Adak, S., Wang, Q., & Stuehr, D. J. (2000) · Journal of Biological Chemistry

Nitric Oxide and Endothelin EffectsMetal-Catalyzed Oxygenation Mechanisms

Cited by 229

Enzymes of the l-arginine to nitric oxide pathway

Stuehr, D. J. (2004) · The Journal of Nutrition

Nitric Oxide and Endothelin EffectsAmino Acid Enzymes and Metabolism

Cited by 218

Novel Mechanism of Activation of NADPH Oxidase 5

Jagnandan, D., Church, J. E., Banfi, B., Stuehr, D. J., Marrero, M. B., & Fulton, D. J. R. (2007) · Journal of Biological Chemistry

Redox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 210

Direct Evidence for Nitric Oxide Production by a Nitric-oxide Synthase-like Protein from Bacillus subtilis

Adak, S., Aulak, K. S., & Stuehr, D. J. (2002) · Journal of Biological Chemistry

Metal-Catalyzed Oxygenation MechanismsNitric Oxide and Endothelin Effects

Cited by 195

Tetrahydrobiopterin Radical Enzymology

Wei, C.-C., Crane, B. R., & Stuehr, D. J. (2003) · Chemical Reviews

Metal-Catalyzed Oxygenation MechanismsMetabolism and Genetic Disorders

Cited by 175

Abnormalities in nitric oxide and its derivatives in lung cancer

Masri, F. A., Comhair, S. A. A., Koeck, T., Xu, W., Janocha, A., Ghosh, S., Dweik, R. A., Golish, J., Kinter, M., Stuehr, D. J., et al. (2005) · American Journal of Respiratory and Critical Care Medicine

Redox biology and oxidative stressNitric Oxide and Endothelin Effects

Cited by 128

Differences in Three Kinetic Parameters Underpin the Unique Catalytic Profiles of Nitric-oxide Synthases I, II, and III

Santolini, J., Meade, A. L., & Stuehr, D. J. (2001) · Journal of Biological Chemistry

Nitric Oxide and Endothelin EffectsHemoglobin structure and function

Cited by 116

N‐terminal domain swapping and metal ion binding in nitric oxide synthase dimerization

Crane, B. R., Rosenfeld, R. J., Arvai, A. S., Ghosh, D. K., Ghosh, S., Tainer, J. A., Stuehr, D. J., & Getzoff, E. D. (1999) · The EMBO Journal

Nitric Oxide and Endothelin EffectsEnzyme Structure and Function

Cited by 110

A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins

Zhang, H., Amick, J., Chakravarti, R., Santarriaga, S., Schlanger, S., McGlone, C., Dare, M., Nix, J. C., Scaglione, K. M., Stuehr, D. J., et al. (2015) · Structure

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 98

Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-l-arginine

Donzelli, S., Espey, M. G., Flores-Santana, W., Switzer, C. H., Yeh, G. C., Huang, J., Stuehr, D. J., King, S. B., Miranda, K. M., & Wink, D. A. (2008) · Free Radical Biology and Medicine

Hemoglobin structure and functionNitric Oxide and Endothelin Effects

Cited by 91

Tetrahydrobiopterin in nitric oxide synthase

Tejero, J., & Stuehr, D. (2013) · IUBMB Life

Nitric Oxide and Endothelin EffectsMetal-Catalyzed Oxygenation Mechanisms

Cited by 75

Nitric oxide blocks cellular heme insertion into a broad range of heme proteins

Waheed, S. M., Ghosh, A., Chakravarti, R., Biswas, A., Haque, M. M., Panda, K., & Stuehr, D. J. (2010) · Free Radical Biology and Medicine

Hemoglobin structure and functionHeme Oxygenase-1 and Carbon Monoxide

Cited by 62

Analysis of Neuronal NO Synthase under Single-Turnover Conditions: Conversion of Nω-Hydroxyarginine to Nitric Oxide and Citrulline

Abu-Soud, H. M., Presta, A., Mayer, B., & Stuehr, D. J. (1997) · Biochemistry

Nitric Oxide and Endothelin EffectsMetal-Catalyzed Oxygenation Mechanisms

Cited by 59

Versatile Regulation of Neuronal Nitric Oxide Synthase by Specific Regions of Its C-Terminal Tail

Tiso, M., Tejero, J., Panda, K., Aulak, K. S., & Stuehr, D. J. (2007) · Biochemistry

Nitric Oxide and Endothelin EffectsHemoglobin structure and function

Cited by 34