The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Laminar specificity of functional MRI onset times during somatosensory stimulation in rat
Open accessAbstract
The blood oxygenation level-dependent (BOLD) response to somatosensory stimulation was measured in α-chloralose-anesthetized rats. BOLD fMRI was obtained at 40-ms temporal resolution and spatial resolution of 200 × 200 × 2,000 μm 3 by using a gated activation paradigm in an 11.7 T MRI. Results show a consistent heterogeneity of fMRI onset times and amplitudes. The earliest onset time (0.59 ± 0.17 s, n = 9) corresponded anatomically to layer IV, with superficial and deeper layers starting significantly later (1.27 ± 0.43 s in layers I–III, and 1.11 ± 0.45 s in layer VI). The amplitude of BOLD signal changes also varied with the cortical depth from the pial surface. Changes in the supragranular layers (8.3%) were 44% bigger than changes in the intermediate layers (5.5%), located only ≈700 μm below, and 144% larger than the bottom layer (3.5%), located ≈1.4 mm below the pial surface. The data presented demonstrate that BOLD signal changes have distinct amplitude and temporal characteristics, which vary spatially across cortical layers.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,551
Kleinfeld, D., Mitra, P. P., Helmchen, F., & Denk, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15741 · Cited by 832
Representation of the temporal envelope of sounds in the human brain
Giraud, A.-L., Lorenzi, C., Ashburner, J., Wable, J., Johnsrude, I., Frackowiak, R., & Kleinschmidt, A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.3.1588 · Cited by 353
Cited by
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
Iadecola, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.030 · Cited by 2,480
Neurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213
The fMRI signal, slow cortical potential and consciousness
He, B. J., & Raichle, M. E. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.04.004 · Cited by 332
Spatio-temporal point-spread function of fMRI signal in human gray matter at 7 Tesla
Shmuel, A., Yacoub, E., Chaimow, D., Logothetis, N. K., & Ugurbil, K. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.030 · Cited by 294
Layer-specific BOLD activation in human V1
Koopmans, P. J., Barth, M., & Norris, D. G. (2010) · Human Brain Mapping · doi:10.1002/hbm.20936 · Cited by 220
Metadata
- Authors
- Silva, A. C., & Koretsky, A. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-10-29
- Volume
- 99
- Issue
- 23
- Pages
- 15182-15187
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1991831794
- Cited by
- 269
- References
- 3
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Laminar specificity of functional MRI onset times during somatosensory stimulation in rat. https://app.cochat.ai/papers/10.1073/pnas.222561899
- The paper
- Silva, A. C., & Koretsky, A. P. (2002). Laminar specificity of functional MRI onset times during somatosensory stimulation in rat. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.222561899
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
