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Cited by 332Neural dynamics and brain functionPhilosophy and Theoretical ScienceFunctional Brain Connectivity Studies

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The fMRI signal, slow cortical potential and consciousness

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He, Biyu J., Raichle, Marcus E.·2009·Trends in Cognitive Sciences
DOI 10.1016/j.tics.2009.04.004PMC PMC2855786
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Abstract

As functional magnetic resonance imaging (fMRI) has become a driving force in cognitive neuroscience, it is crucial to understand the neural basis of the fMRI signal. Here, we discuss a novel neurophysiological correlate of the fMRI signal, the slow cortical potential (SCP), which also seems to modulate the power of higher-frequency activity, the more established neurophysiological correlate of the fMRI signal. We further propose a hypothesis for the involvement of the SCP in the emergence of consciousness, and review existing data that lend support to our proposal. This hypothesis, unlike several previous theories of consciousness, is firmly rooted in physiology and as such is entirely amenable to empirical testing.

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Metadata

Authors
He, B. J., & Raichle, M. E.
Affiliations
Washington University in St. Louis (US)
Corresponding author
He, Biyu J.
ORCID
Venue
Trends in Cognitive Sciences
Publisher
Elsevier BV
Published
2009-07
Volume
13
Issue
7
Pages
302-309
ISSN
1364-6613 (ISSN-L)
DOI
10.1016/j.tics.2009.04.004
PMC
PMC2855786
OpenAlex
W2105642595
Cited by
332
References
17
Citations by year
2026: 7 · 2025: 7 · 2024: 8 · 2023: 12 · 2022: 16 · 2021: 15 · 2020: 23 · 2019: 15 · 2018: 10 · 2017: 24 · 2016: 23 · 2015: 25 · 2014: 31 · 2013: 36 · 2012: 24
FWCI
1.94
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Cognitive Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (P50NS006833)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Social Sciences › Arts and Humanities › Philosophy › Philosophy and Theoretical Science
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
fMRI signal, slow cortical potentials, consciousness, theory of consciousness, neurophysiological correlates, emergence of consciousness
MeSH terms
Brain Mapping, Cerebral Cortex, Consciousness, Electroencephalography, Evoked Potentials, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Models, Neurological, Oxygen

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