The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment
Open accessAbstract
The retinoic acid (RA) signal, produced locally from vitamin A by retinaldehyde dehydrogenase (Raldh) and transduced by the nuclear receptors for retinoids (RA receptor and 9- cis -RA receptor), is indispensable for ontogenesis and homeostasis of numerous tissues. We demonstrate that Raldh3 knockout in mouse suppresses RA synthesis and causes malformations restricted to ocular and nasal regions, which are similar to those observed in vitamin A-deficient fetuses and/or in retinoid receptor mutants. Raldh3 knockout notably causes choanal atresia (CA), which is responsible for respiratory distress and death of Raldh3 -null mutants at birth. CA is due to persistence of nasal fins, whose rupture normally allows the communication between nasal and oral cavities. This malformation, which is similar to isolated congenital CA in humans and may result from impaired RA-controlled down-regulation of Fgf8 expression in nasal fins, can be prevented by a simple maternal treatment with RA.
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Cites
A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889
Self-citationDuester, G. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01497.x · Cited by 570
Niederreither, K., Fraulob, V., Garnier, J.-M., Chambon, P., & Dollé, P. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00561-5 · Cited by 246
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Cited by
Retinoic Acid Synthesis and Signaling during Early Organogenesis
Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098
Retinoic acid signalling during development
Rhinn, M., & Dollé, P. (2012) · Development · doi:10.1242/dev.065938 · Cited by 849
Retinoic acid in development: Towards an integrated view
Niederreither, K., & Dollé, P. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2340 · Cited by 726
Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress
Singh, S., Brocker, C., Koppaka, V., Chen, Y., Jackson, B. C., Matsumoto, A., Thompson, D. C., & Vasiliou, V. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.010 · Cited by 601
Mechanisms of retinoic acid signalling and its roles in organ and limb development
Cunningham, T. J., & Duester, G. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3932 · Cited by 598
Metadata
- Authors
- Dupé, V., Matt, N., Garnier, J.-M., Chambon, P., Mark, M., & Ghyselinck, N. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-11-17
- Volume
- 100
- Issue
- 24
- Pages
- 14036-14041
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2149940976
- Cited by
- 315
- References
- 3
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Dupé, V., Matt, N., Garnier, J.-M., Chambon, P., Mark, M., & Ghyselinck, N. B. (2003). A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2336223100
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