Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse
Open accessAbstract
Three retinaldehyde dehydrogenases (RALDH1, RALDH2 and RALDH3), which catalyze the oxidation of retinaldehyde into retinoic acid, have been shown to be differentially expressed during early embryogenesis. Here, we report their differential expression patterns throughout later mouse organogenesis. Raldh1 is prominently expressed in developing lung (notably in bronchial and tracheal epithelia), and shows stage-specific expression in stomach and intestine epithelial and mesenchymal layers. Raldh3 expression is specific to the differentiating intestinal lamina propria. Raldh2 is expressed throughout the kidney nephrogenic zone, whereas Raldh1 and Raldh3 are mostly expressed in collecting duct epithelia. Raldh3 expression is more restricted than that of Raldh1 in the urogenital tract and sex gland epithelia, whereas Raldh2 expression is mesenchymal. Raldh1 is coexpressed with Raldh2 in the early heart epicardium, and is later specifically expressed in developing heart valves. All three genes exhibit distinct expression patterns in respiratory and olfactory epithelia and/or mesenchymes, and in developing teeth. Only Raldh1 expression is seen after birth in specific brain structures. These data indicate a requirement for regulated RA synthesis in various differentiating organs.
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ATRA has been reported to be the triggering factor in the meiotic entry process in animal models and humans.
“ATRA has been reported to be the triggering factor in the meiotic entry process in animal models and humans [238,239,240].”
From Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use and Toxicity (2021) · cites this paper as [239]
The Abstract describes retinoic acid synthesis and RALDH expression during mouse development, but does not address meiotic entry. A search for meiosis and germ cells found no passage linking retinoic acid to the initiation of meiosis in animals or humans. (LLM, conf=0.75)
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Cites
Métézeau, P. (1998) · Research in Microbiology · doi:10.1016/s0923-2508(98)80442-7 · Cited by 1,254 · see citing works
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
Niederreither, K., Subbarayan, V., Dollé, P., & Chambon, P. (1999) · Nature Genetics · doi:10.1038/7788 · Cited by 1,111 · see citing works
Self-citationNiederreither, K., McCaffery, P., Dräger, U. C., Chambon, P., & Dollé, P. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00653-3 · Cited by 523 · see citing works
Self-citationHuman aldehyde dehydrogenase gene family
Yoshida, A., Rzhetsky, A., Hsu, L. C., & Chang, C. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2510549.x · Cited by 478 · see citing works
Anatomy and embryology of the laboratory rat
Hebel, R., & Stromberg, M. W. (1986) · Cited by 433 · see citing works
Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse
Niederreither, K., Vermot, J., Messaddeq, N., Schuhbaur, B., Chambon, P., & Dollé, P. (2001) · Development · doi:10.1242/dev.128.7.1019 · Cited by 418 · see citing works
Self-citationRetinoic acid synthesis and hindbrain patterning in the mouse embryo
Niederreither, K., Vermot, J., Schuhbaur, B., Chambon, P., & Dollé, P. (2000) · Development · doi:10.1242/dev.127.1.75 · Cited by 378 · see citing works
Self-citationZhao, D., McCaffery, P. J. A., Ivins, K. J., Neve, R. L., Hogan, P. G., Chin, W. W., & Dräger, U. C. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0015h.x · Cited by 344 · see citing works
Regulation of retinoic acid signaling during lung morphogenesis
Malpel, S., Mendelsohn, C. L., & Cardoso, W. V. (2000) · Development · doi:10.1242/dev.127.14.3057 · Cited by 274 · see citing works
Fate of Mesencephalic AHD2-Expressing Dopamine Progenitor Cells in Nurr1 Mutant Mice
Wallén, Å., Zetterström, R. H., Solomin, L., Arvidsson, M., Olson, L., & Perlmann, T. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4691 · Cited by 232 · see citing works
Dynamic Patterns of Retinoic Acid Synthesis and Response in the Developing Mammalian Heart
Moss, J. B., Xavier‐Neto, J., Shapiro, M. D., Nayeem, S. M., McCaffery, P. J. A., Dräger, U. C., & Rosenthal, N. A. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8911 · Cited by 231 · see citing works
MacLean, G. A., Abu–Abed, S., Dollé, P., Tahayato, A., Chambon, P., & Petkovich, M. P. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00463-4 · Cited by 224 · see citing works
Self-citationMetabolic Deficiencies in Alcohol Dehydrogenase Adh1,Adh3, and Adh4 Null Mutant Mice
Deltour, L., Foglio, M. H., & Duester, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.16796 · Cited by 190 · see citing works
Cloning of a cDNA Encoding an Aldehyde Dehydrogenase and Its Expression in
Wang, X., Penzes, P., & Napoli, J. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.27.16288 · Cited by 169 · see citing works
A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse.
Li, H., Wagner, E., McCaffery, P., Smith, D., Andreadis, A., & Dräger, U. C. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00352-x · Cited by 167 · see citing works
Mic, F. A., Molotkov, A., Fan, X., Cuenca, A. E., & Duester, G. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00434-2 · Cited by 163 · see citing works
Grün, F., Hirose, Y., Kawauchi, S., Ogura, T., & Umesono, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007376200 · Cited by 129 · see citing works
Suzuki, R., Shintani, T., Sakuta, H., Kato, A., Ohkawara, T., Osumi, N., & Noda, M. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00450-0 · Cited by 107 · see citing works
In Situ Hybridization with 35S-Labeled Probes for Retinoid Receptors
Niederreither, K., & Dollé, P. (1998) · Humana Press eBooks · doi:10.1385/0-89603-438-0:247 · Cited by 30 · see citing works
Self-citationKathmann, E. C., Naylor, S., & Lipsky, J. J. (2000) · Biochemistry · doi:10.1021/bi001120m · Cited by 23 · see citing works
Changing Patterns of Renal Retinal Dehydrogenase Expression Parallel Nephron Development in the Rat
Bhat, P. V., Marcinkiewicz, M. M., Li, Y., et al. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804600906 · Cited by 20 · see citing works
Yun, U. J., Kim, S. Y., Liu, J., Adler, P. N., Bae, E., Kim, J., & Park, W. J. (1999) · Developmental Genetics · doi:10.1002/(sici)1520-6408(1999)25:4 · Cited by 16 · see citing works
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Clagett-Dame, M., & Knutson, D. (2011) · Nutrients · doi:10.3390/nu3040385 · Cited by 439 · see citing works
“In the embryonic kidney, Raldh2 is localized in stromal mesenchyme of the outer cortex and Raldh3 is expressed in the ureteric bud [130,237,238].”
BackgroundCarazo, A., Macáková, K., Matoušová, K., Krčmová, L. K., Protti, M., & Mladěnka, P. (2021) · Nutrients · doi:10.3390/nu13051703 · Cited by 418 · see citing works
DeSisto, J., O’Rourke, R., Jones, H. E., Pawlikowski, B., Malek, A. D., Bonney, S., Guimiot, F., Jones, K. L., & Siegenthaler, J. A. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.009 · Cited by 241 · see citing works
Alcohol and aldehyde dehydrogenases: Retinoid metabolic effects in mouse knockout models
Kumar, S., Sandell, L. L., Trainor, P. A., Koentgen, F., & Duester, G. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.04.004 · Cited by 190 · see citing works
Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke.
Kelly, K. K., MacPherson, A. M., Grewal, H., Strnad, F., Jones, J. W., Yu, J., Pierzchalski, K., Kane, M. A., Herson, P. S., & Siegenthaler, J. A. (2016) · BMC Neuroscience · doi:10.1186/s12868-016-0284-5 · Cited by 75 · see citing works
Kim, Y.-K., Wassef, L., Hamberger, L., Piantedosi, R., Palczewski, K., Blaner, W. S., & Quadro, L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708885200 · Cited by 80 · see citing works
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Hiriart, E., Deepe, R., & Wessels, A. (2019) · Journal of Developmental Biology · doi:10.3390/jdb7020007 · Cited by 66 · see citing works
Uebi, T., Umeda, M., & Imai, T. (2015) · Genes to Cells · doi:10.1111/gtc.12214 · Cited by 52 · see citing works
- Authors
- Niederreither, K., Fraulob, V., Garnier, J.-M., Chambon, P., & Dollé, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Dollé, Pascal
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 110
- Issue
- 1-2
- Pages
- 165-171
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W1971045517
- Cited by
- 246
- References
- 22
- Citations by year
- 2025: 4 · 2024: 8 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 16 · 2019: 11 · 2018: 10 · 2017: 6 · 2016: 10 · 2015: 11 · 2014: 15 · 2013: 11 · 2012: 12
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Association pour la Recherche sur le Cancer
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- retinaldehyde dehydrogenase, ALDH1A1, Raldh2, retinoic acid synthesis, gene expression patterns, organogenesis, lung development, intestinal lamina propria, heart development, heart valves, urogenital tract, gonads, tooth development, olfactory epithelium, brain, mouse embryo
- MeSH terms
- Abdomen, Aldehyde Oxidoreductases, Animals, Brain, Facial Bones, Embryonic and Fetal Development, Heart Valves, Male, Organ Specificity, Skull, Tooth, Tretinoin, Gene Expression Regulation, Enzymologic, In Situ Hybridization, Gene Expression Regulation, Developmental, Hair Follicle, Retinal Dehydrogenase, Mice
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