The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Recombination and mutation during long-term gastric colonization by Helicobacter pylori : Estimates of clock rates, recombination size, and minimal age
Open accessAbstract
The bacterium Helicobacter pylori colonizes the gastric mucosa of half of the human population, resulting in chronic gastritis, ulcers, and cancer. We sequenced ten gene fragments from pairs of strains isolated sequentially at a mean interval of 1.8 years from 26 individuals. Several isolates had acquired small mosaic segments from other H. pylori or point mutations. The maximal mutation rate, the import size, and the frequency of recombination were calculated by using a Bayesian model. The calculations indicate that the last common ancestor of H. pylori existed at least 2,500–11,000 years ago. Imported mosaics have a median size of 417 bp, much smaller than for other bacteria, and recombination occurs frequently (60 imports spanning 25,000 bp per genome per year). Thus, the panmictic population structure of H. pylori results from very frequent recombination during mixed colonization by unrelated strains.
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Self-citationFree recombination within Helicobacter pylori
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Cited by
Pathogenesis of Helicobacter pylori Infection
Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00054-05 · Cited by 2,526
Multilocus Sequence Typing of Bacteria
Maiden, M. C. J. (2006) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121325 · Cited by 915
Pathogenicity Islands in BacterialPathogenesis
Schmidt, H., & Hensel, M. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.1.14-56.2004 · Cited by 776
Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosis
Gutierrez, M. C., Brisse, S., Brosch, R., Fabre, M., Omaïs, B., Marmiesse, M., Supply, P., & Vincent, V. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010005 · Cited by 646
THE PATHOGENESIS OF HELICOBACTER PYLORI–INDUCED GASTRO-DUODENAL DISEASES
Atherton, J. C. (2006) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100125 · Cited by 567
Metadata
- Authors
- Falush, D., Kraft, C., Taylor, N. S., Correa, P., Fox, J. G., Achtman, M., & Suerbaum, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-12-11
- Volume
- 98
- Issue
- 26
- Pages
- 15056-15061
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2169812063
- Cited by
- 429
- References
- 32
- FWCI
- 16.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Falush, D., Kraft, C., Taylor, N. S., Correa, P., Fox, J. G., Achtman, M., & Suerbaum, S. (2001). Recombination and mutation during long-term gastric colonization by Helicobacter pylori : Estimates of clock rates, recombination size, and minimal age. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.251396098
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
