The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Transcriptome analysis of chlamydial growth during IFN-γ-mediated persistence and reactivation
Open accessAbstract
Chlamydia trachomatis is an obligatory intracellular prokaryotic parasite that causes a spectrum of clinically important chronic inflammatory diseases of humans. Persistent infection may play a role in the pathophysiology of chlamydial disease. Here we describe the chlamydial transcriptome in an in vitro model of IFN-γ-mediated persistence and reactivation from persistence. Tryptophan utilization, DNA repair and recombination, phospholipid utilization, protein translation, and general stress genes were up-regulated during persistence. Down-regulated genes included chlamydial late genes and genes involved in proteolysis, peptide transport, and cell division. Persistence was characterized by altered but active biosynthetic processes and continued replication of the chromosome. On removal of IFN-γ, chlamydiae rapidly reentered the normal developmental cycle and reversed transcriptional changes associated with cytokine treatment. The coordinated transcriptional response to IFN-γ implies that a chlamydial response stimulon has evolved to control the transition between acute and persistent growth of the pathogen. In contrast to the paradigm of persistence as a general stress response, our findings suggest that persistence is an alternative life cycle used by chlamydiae to avoid the host immune response.
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Cites
Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis
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Phospholipase D: molecular and cell biology of a novel gene family
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Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis
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Self-citationChlamydial Infections: (First of Three Parts)
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Self-citationImmunity to Murine Chlamydial Genital Infection
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Cited by
Persistent bacterial infections and persister cells
Fisher, R. A., Gollan, B., & Helaine, S. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.42 · Cited by 1,243
A nutritive view on the host–pathogen interplay
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(2019) · doi:10.7554/elife.42295 · Cited by 31
Bellmann-Weiler, R., Martinz, V., Kurz, K., Engl, S., Feistritzer, C., Fuchs, D., Rupp, J., Paldanius, M., & Weiss, G. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.05.021 · Cited by 27
Metadata
- Authors
- Belland, R. J., Nelson, D. E., Virok, D., Crane, D. D., Hogan, D., Sturdevant, D., Beatty, W. L., & Caldwell, H. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-12-12
- Volume
- 100
- Issue
- 26
- Pages
- 15971-15976
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1968722509
- Cited by
- 270
- References
- 19
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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