The DOI matches its Crossref record.
Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis
Abstract
Analysis of the 1,042,519–base pair Chlamydia trachomatis genome revealed unexpected features related to the complex biology of chlamydiae. Although chlamydiae lack many biosynthetic capabilities, they retain functions for performing key steps and interconversions of metabolites obtained from their mammalian host cells. Numerous potential virulence-associated proteins also were characterized. Several eukaryotic chromatin-associated domain proteins were identified, suggesting a eukaryotic-like mechanism for chlamydial nucleoid condensation and decondensation. The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.
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Citations
Cited by
Horizontal gene transfer in prokaryotes: Quantification and classification
Koonin, E. V., Makarova, K. S., & Aravind, L. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.709 · Cited by 1,126
Self-citationDiagnostics for the developing world
Mabey, D., Peeling, R. W., Ustianowski, A., & Perkins, M. D. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro841 · Cited by 1,054
Delcher, A. L., Kasif, S., Fleischmann, R. D., Peterson, J., White, O., & Salzberg, S. L. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.11.2369 · Cited by 893
The chlamydial developmental cycle: Figure 1
AbdelRahman, Y. M., & Belland, R. J. (2005) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2005.03.002 · Cited by 631
Endosymbiotic theory for organelle origins
Zimorski, V., Ku, C., Martin, W. F., & Gould, S. B. (2014) · Current Opinion in Microbiology · doi:10.1016/j.mib.2014.09.008 · Cited by 453
Metadata
- Authors
- Stephens, R. S., Kalman, S., Lammel, C., Fan, J., Marathe, R., Aravind, L., Mitchell, W., Olinger, L., Tatusov, R. L., Zhao, Q., Koonin, E. V., & Davis, R. W.
- Venue
- Science
- Published
- 1998-10-23
- Volume
- 282
- Issue
- 5389
- Pages
- 754-759
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2115780677
- Cited by
- 1,563
- References
- 0
- FWCI
- 76.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stephens, R. S., Kalman, S., Lammel, C., Fan, J., Marathe, R., Aravind, L., Mitchell, W., Olinger, L., Tatusov, R. L., Zhao, Q., Koonin, E. V., & Davis, R. W. (1998). Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis. Science. https://doi.org/10.1126/science.282.5389.754
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