The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Structural organization of yeast and mammalian mediator complexes
Open accessAbstract
Structures of yeast Mediator complex, of a related complex from mouse cells and of thyroid hormone receptor-associated protein complex from human cells have been determined by three-dimensional reconstruction from electron micrographs of single particles. All three complexes show a division in two parts, a “head” domain and a combined “middle-tail” domain. The head domains of the three complexes appear most similar and interact most closely with RNA polymerase II. The middle-tail domains show the greatest structural divergence and, in the case of the tail domain, may not interact with polymerase at all. Consistent with this structural divergence, analysis of a yeast Mediator mutant localizes subunits that are not conserved between yeast and mammalian cells to the tail domain. Biochemically defined Rgr1 and Srb4 modules of yeast Mediator are then assigned to the middle and head domains.
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Cites
Transcriptional activation by recruitment
Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158
A mediator required for activation of RNA polymerase II transcription in vitro
Flanagan, P. M., Kelleher, R. J., Sayre, M. H., Tschochner, H., & Kornberg, R. D. (1991) · Nature · doi:10.1038/350436a0 · Cited by 386
Self-citationMediator protein mutations that selectively abolish activated transcription
Myers, L. C., Gustafsson, C. M., Hayashibara, K. C., Brown, P. O., & Kornberg, R. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.1.67 · Cited by 181
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Cited by
Transcription regulation and animal diversity
Levine, M., & Tjian, R. (2003) · Nature · doi:10.1038/nature01763 · Cited by 1,309
The Mediator complex: a central integrator of transcription
Allen, B. L., & Taatjes, D. J. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3951 · Cited by 922
PPARα: Energy Combustion, Hypolipidemia, Inflammation and Cancer
Pyper, S. R., Viswakarma, N., Yu, S., & Reddy, J. K. (2010) · Nuclear Receptor Signaling · doi:10.1621/nrs.08002 · Cited by 379
Structure, Function, and Activator-Induced Conformations of the CRSP Coactivator
Taatjes, D. J., Näär, A. M., Andel, F., Nogales, E., & Tjian, R. (2002) · Science · doi:10.1126/science.1065249 · Cited by 277
Evidence for a Mediator of RNA Polymerase II Transcriptional Regulation Conserved from Yeast to Man
Boube, M., Joulia, L., Cribbs, D. L., & Bourbon, H.-M. (2002) · Cell · doi:10.1016/s0092-8674(02)00830-9 · Cited by 262
Metadata
- Authors
- Dotson, M. R., Yuan, C. X., Roeder, R. G., Myers, L. C., Gustafsson, C. M., Jiang, Y. W., Li, Y., Kornberg, R. D., & Asturias, F. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-12-12
- Volume
- 97
- Issue
- 26
- Pages
- 14307-14310
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2047009255
- Cited by
- 211
- References
- 3
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- green
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