The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Genome-wide study of aging and oxidative stress response in Drosophilamelanogaster
Open accessAbstract
Aging is a universal but poorly understood biological process. Free radicals accumulate with age and have been proposed to be a major cause of aging. We measured genome-wide changes in transcript levels as a function of age in Drosophila melanogaster and compared these changes with those caused by paraquat, a free-radical generator. A number of genes exhibited changes in transcript levels with both age and paraquat treatment. We also found genes whose transcript levels changed with age but not with paraquat treatment. This study suggests that free radicals play an important role in regulating transcript levels in aging but that they are not the only factors. This genome-wide survey also identifies candidates for molecular markers of aging.
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Cites
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Cited by
Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883
Aging Biology and Geriatric Clinical Pharmacology
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Yankner, B. A., Lu, T., & Loerch, P. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.2.010506.092044 · Cited by 677
Insect CYP Genes and P450 Enzymes
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Self-citation
Metadata
- Authors
- Zou, S., Meadows, S., Sharp, L., Jan, L. Y., & Jan, Y. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-11-28
- Volume
- 97
- Issue
- 25
- Pages
- 13726-13731
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2113374835
- Cited by
- 313
- References
- 36
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Zou, S., Meadows, S., Sharp, L., Jan, L. Y., & Jan, Y. N. (2000). Genome-wide study of aging and oxidative stress response in Drosophilamelanogaster. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.260496697
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
