The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Extensive and specific responses of a eukaryote to bacterial quorum-sensing signals
Open accessAbstract
Many bacteria use N -acyl homoserine lactone (AHL) signals to coordinate the behavior of individual cells in a local population. The successful infection of eukaryotic hosts by bacteria seems to depend particularly on such AHL-mediated “quorum-sensing” regulation. We have used proteome analysis to show that a eukaryotic host, the model legume Medicago truncatula , is able to detect nanomolar to micromolar concentrations of bacterial AHLs from both symbiotic ( Sinorhizobium meliloti ) and pathogenic ( Pseudomonas aeruginosa ) bacteria, and that it responds in a global manner by significant changes in the accumulation of over 150 proteins, 99 of which have been identified by peptide mass fingerprinting. The accumulation of specific proteins and isoforms depended on AHL structure, concentration, and time of exposure. AHLs were also found to induce tissue-specific activation of β-glucuronidase ( GUS ) reporter fusions to an auxin-responsive and three chalcone synthase promoters, consistent with AHL-induced changes in the accumulation of auxin-responsive and flavonoid synthesis proteins. In addition, exposure to AHLs was found to induce changes in the secretion of compounds by the plants that mimic quorum-sensing signals and thus have the potential to disrupt quorum sensing in associated bacteria. Our results indicate that eukaryotes have an extensive range of functional responses to AHLs that may play important roles in the beneficial or pathogenic outcomes of eukaryote–prokaryote interactions.
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Cites
Quorum-sensing in Gram-negative bacteria
Whitehead, N. (2001) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(01)00059-6 · Cited by 1,607
Structural identification of a bacterial quorum-sensing signal containing boron
Chen, X., Schauder, S., Potier, N., Van Dorsselaer, A., Pelczer, I., Bassler, B. L., & Hughson, F. M. (2002) · Nature · doi:10.1038/415545a · Cited by 1,571
Regulation of Gene Expression by Cell-to-Cell Communication: Acyl-Homoserine Lactone Quorum Sensing
Fuqua, C., Parsek, M. R., & Greenberg, E. P. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.090913 · Cited by 1,388
Bacterial Quorum Sensing in Pathogenic Relationships
de Kievit, T. R., & Iglewski, B. H. (2000) · Infection and Immunity · doi:10.1128/iai.68.9.4839-4849.2000 · Cited by 1,110
Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes.
Pearson, J. P., Gray, K. M., Passador, L., Tucker, K. D., Eberhard, A., Iglewski, B. H., & Greenberg, E. P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.197 · Cited by 990
Programmed cell death, mitochondria and the plant hypersensitive response
Lam, E., Kato, N., & Lawton, M. (2001) · Nature · doi:10.1038/35081184 · Cited by 900
Winson, M. (1998) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(98)00172-4 · Cited by 593
Teplitski, M., Robinson, J. B., & Bauer, W. D. (2000) · Molecular Plant-Microbe Interactions® · doi:10.1094/mpmi.2000.13.6.637 · Cited by 591
Self-citationMedicago truncatula — a model in the making!
Cook, D. R. (1999) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(99)80053-3 · Cited by 567
Mathesius, U., Schlaman, H. R. M., Spaink, H. P., Of Sautter, C., Rolfe, B. G., & Djordjevic, M. A. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00090.x · Cited by 471
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Cited by
THE ROLE OF ROOT EXUDATES IN RHIZOSPHERE INTERACTIONS WITH PLANTS AND OTHER ORGANISMS
Bais, H. P., Weir, T. L., Perry, L. G., Gilroy, S., & Vivanco, J. M. (2006) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105159 · Cited by 4,682
Structure and functions of the bacterial microbiota of plants
Bulgarelli, D., Schlaeppi, K., Spaepen, S., van Themaat, E. V. L., & Schulze-Lefert, P. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120106 · Cited by 3,308
Compant, S., Duffy, B., Nowak, J., Clément, C., & Barka, E. A. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.9.4951-4959.2005 · Cited by 2,640
Indole-3-acetic acid in microbial and microorganism-plant signaling
Spaepen, S., Vanderleyden, J., & Remans, R. (2007) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2007.00072.x · Cited by 1,954
Inter-kingdom signalling: Communication between bacteria and their hosts
Hughes, D. T., & Sperandio, V. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1836 · Cited by 761
Metadata
- Authors
- Mathesius, U., Mulders, S., Gao, M., Teplitski, M., Caetano-Anollés, G., Rolfe, B. G., & Bauer, W. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-01-02
- Volume
- 100
- Issue
- 3
- Pages
- 1444-1449
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1969395262
- Cited by
- 532
- References
- 21
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- green
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