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Cited by 900

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Programmed cell death, mitochondria and the plant hypersensitive response

Lam, Eric, Kato, Naohiro, Lawton, Michael·2001·Nature
DOI 10.1038/35081184
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  1. Feys, B. J. & Parker, J. E. Interplay of signaling pathways in plant disease resistance. Trends Genet. 16, 449–455 (2000). · DOI · Paper page
  2. Baker, B., Zambryski, P., Staskawicz, B. & Dinesh-Kumer, S. P. Signaling in plant-microbe interactions. Science 276, 726–733 (1997). · DOI · Paper page
  3. Morel, J.-B. & Dangl, J. The hypersensitive response and the induction of cell death in plants. Cell Death Differ. 4, 671–683 (1997). · DOI
  4. Heath, M. C. Nonhost resistance and nonspecific plant defenses. Curr. Opin. Plant Biol. 3, 315–319 (2000). · DOI · Paper page
  5. Heath, M. C. Hypersensitive response-related death. Plant Mol. Biol. 44, 321–334 (2000). · DOI · Paper page
  6. Dinesh-Kumar, S. P., Tham, W.-H. & Baker, B. Structure-function analysis of the tobacco mosaic virus resistance gene N . Proc. Natl Acad. Sci. USA 97, 14789–14794 (2000). · DOI · Paper page
  7. Erickson, F. L. et al. The helicase domain of the TMV replicase proteins induces the N-mediated defence response in tobacco. Plant J. 18, 67–75 (1999). · DOI · Paper page
  8. White, E. Life, death, and the pursuit of apoptosis. Genes Dev. 10, 1–15 (1996). · DOI · Paper page
  9. Clem, R. J., Hardwick, J. M. & Miller, L. K. Anti-apoptotic genes of baculoviruses. Cell Death Differ. 3, 9–16 (1996).
  10. Green, D. R. Apoptotic pathways: paper wraps stone blunts scissors. Cell 102, 1–4 (2000). · DOI · Paper page
  11. Uren, A. G. et al. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol. Cell 6, 961–967 (2000).
  12. Shirasu, K. & Schulze-Lefert, P. Regulators of cell death in disease resistance. Plant Mol. Biol. 44, 371–385 (2000). · DOI · Paper page
  13. Hammond-Kosack, K. E., Silverman, P., Raskin, I. & Jones, J. D. G. Race-specific elicitors of Cladosporium fulvum induce changes in cell morphology and the synthesis of ethylene and salicylic acid in tomato plants carrying the corresponding Cf disease resistance gene. Plant Physiol. 110, 1381–1394 (1996). · doi:10.1104/pp.110.4.1381
  14. Clough, S. J. et al. The Arabidopsis dnd1 “defense, no death” gene encodes a mutated cyclic nucleotide-gated ion channel. Proc. Natl. Acad. Sci. USA 97, 9323–9328 (2000). · DOI · Paper page
  15. Bendahmane, A., Kanyuka, K. & Baulcombe, D. The Rx gene from potato controls separate virus resistance and cell death responses. Plant Cell 11, 781–791 (1999). · DOI
  16. Govrin, E. M. & Levine, A. The hypersensitive response facilitates plant infection by the necrotrophic pathogen Botrytis cinerea . Curr. Biol. 10, 751–757 (2000). · DOI · Paper page
  17. Navarre, W. W. & Zychlinsky, A. Pathogen-induced apoptosis of macrophages: a common end for different pathogenic strategies. Cell Microbiol. 2, 265–273 (2000). · DOI · Paper page
  18. Ferri, K. F. & Kroemer, G. Mitochondria - the suicide organelles. BioEssays 23, 111–115 (2001). · DOI · Paper page
  19. Vander Heiden, M. G. et al. Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proc. Natl Acad. Sci. USA 97, 4666–4671 (2000). · DOI · Paper page
  20. Chai, J. et al. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature 406, 855–862 (2000). · DOI · Paper page
  21. Blackstone, N. W. & Green, D. R. The evolution of a mechanism of cell suicide. BioEssays 21, 84–88 (1999). · DOI
  22. Lam, E., Pontier, D. & del Pozo, O. Die and let live - programmed cell death in plants. Curr. Opin. Plant Biol. 2, 502–507 (1999). · DOI
  23. Xie, Z. & Chen, Z. Harpin-induced hypersensitive cell death is associated with altered mitochondrial functions in tobacco cells. Mol. Plant-Microbe Interact. 13, 183–190 (2000). · doi:10.1094/mpmi.2000.13.2.183
  24. Lacomme, C. & Santa Cruz, S. Bax-induced cell death in tobacco is similar to the hypersensitive response. Proc. Natl Acad. Sci. USA 96, 7956–7961 (1999). · DOI · Paper page
  25. Chivasa, S. & Carr, J. Cyanide restores N gene-mediated resistance to tobacco mosaic virus in transgenic tobacco expressing salicylic acid hydroxylase. Plant Cell 10, 1489–1498 (1998).
  26. Maxwell, D. P., Wang, Y. & McIntosh, L. The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells. Proc. Natl Acad. Sci. USA 96, 8271–8276 (1999). · DOI · Paper page
  27. Simons, B. H., Millenaar, F. F., Mulder, L., Van Loon, L. C. & Lambers, H. Enhanced expression and activation of the alternative oxidase during infection of Arabidopsis with Pseudomonas syringae pv. tomato . Plant Physiol. 20, 529–538 (1999). · DOI · Paper page
  28. Keller, T. et al. A plant homolog of the neutrophil NADPH oxidase gp91phox subunit gene encodes a plasma membrane protein with Ca2+ binding motifs. Plant Cell 10, 255–266 (1998).
  29. Torres, M. A. et al. Six Arabidopsis homologues of the human respiratory burst oxidase (gp91phox). Plant J. 14, 365–370 (1998). · DOI · Paper page
  30. Seo, S. et al. Reduced levels of chloroplast FtsH protein in tobacco mosaic virus-infected tobacco leaves accelerate the hypersensitive response. Plant Cell 12, 917–932 (2000). · DOI
  31. Wilson, I., Vogel, J. & Somerville, S. Signalling pathways: a common theme in plants and animals? Curr. Biol. 7, R175–R178 (1997). · doi:10.1016/s0960-9822(97)70082-4
  32. van der Biezen, E. A. & Jones, J. D. G. The NB-ARC domain: a novel signalling motif shared by plant resistance gene products and regulators of cell death in animals. Curr. Biol. 8, R226–R227 (1998). · DOI · Paper page
  33. Aravind, L., Dixit, V. M. & Koonin, E. V. The domains of death: evolution of the apoptosis machinery. Trends Biochem. Sci. 24, 47–53 (1999). · DOI · Paper page
  34. Zhang, Y., Fan, W., Kinkema, M., Li, X. & Dong, X. Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. Proc. Natl Acad. Sci. USA 96, 6523–6528 (1999). · DOI · Paper page
  35. Zhou, J.-M. et al. NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid. Mol. Plant-Microbe Interact. 13, 191–219 (2000). · DOI · Paper page
  36. Depres, D., DeLong, C., Glaze, S., Liu, E. & Fobert, P. R. The Arabidopsis NPR1/NIM1 protein enhances the DNA binding activity of a subgroup of the TGA family of bZIP transcription factors. Plant Cell 12, 279–290 (2000). · DOI · Paper page
  37. Daniel, X., Lacomme, C., Morel, J. B. & Roby, D. A novel myb oncogene homologue in Arabidopsis thaliana related to hypersensitive cell death. Plant J. 20, 57–66 (1999). · doi:10.1046/j.1365-313x.1999.00578.x
  38. Mayda, E., Tornero, P., Conejero, V. & Vera, P. A tomato homeobox gene (HD-zip) is involved in limiting the spread of programmed cell death. Plant J. 20, 591–600 (1999). · doi:10.1046/j.1365-313x.1999.00633.x
  39. Euglem, T., Rushton, P. J., Robatzek, S. & Somssich, I. The WRKY superfamily of plant transcription factors. Trends Plant Sci. 5, 199–206 (2000). · DOI · Paper page
  40. Maleck, K. et al. The transcriptome of Arabidopsis thaliana during systemic acquired resistance. Nature Genet. 26, 403–410 (2000). · DOI · Paper page
  41. Kawasaki, T. et al. The small GTP-binding protein Rac is a regulator of cell death in plants. Proc. Natl Acad. Sci. USA 96, 10922–10926 (1999). · DOI · Paper page
  42. Bergmann, A., Agapite, J., McCall, K. & Steller, H. The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331–341 (1998). · DOI · Paper page
  43. del Pozo, O. & Lam, E. Caspases and programmed cell death in the hypersensitive response of plants to pathogens. Curr. Biol. 8, 1129–1132 (1998). · DOI · Paper page
  44. Korthout, H. A. A. J., Berecki, G., Bruin, W., van Duijn, B. & Wang, M. The presence and subcellular localization of caspase 3-like proteinases in plant cells. FEBS Lett. 475, 139–144 (2000). · doi:10.1016/s0014-5793(00)01643-4
  45. Jabs, T., Dietrich, R. A. & Dangl, J. L. Initiation of runaway cell death in an Arabidopsis mutant by extracellular superoxide. Science 273, 1853–1856 (1996). · DOI · Paper page
  46. Johnson, D. E. Noncaspase proteases in apoptosis. Leukemia 9, 1695–1703 (2000). · DOI · Paper page
  47. Solomon, M., Belenghi, B., Delledonne, M., Menachem, E. & Levine, A. The involvement of cysteine proteases and protease inhibitor genes in the regulation of programmed cell death in plants. Plant Cell 11, 431–444 (1999). · DOI · Paper page
  48. Aravind, L., Dixit, V. M. & Koonin, E. V. Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons. Science 291, 1279–1284 (2001). · DOI · Paper page
  49. Zha, H. et al. Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells. Mol. Cell. Biol. 16, 6494–6508 (1996). · DOI · Paper page
  50. Mitsuhara, I., Malik, K. A., Miura, M. & Ohashi, Y. Animal cell-death suppressors Bcl-xL and Ced-9 inhibit cell death in tobacco plants. Curr. Biol. 9, 775–778 (1999). · DOI · Paper page
  51. Xu, Q. & Reed, J. C. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol. Cell 1, 337–346 (1998). · DOI · Paper page
  52. Kawai, M., Pan, L., Reed., J. C. & Uchimiya, H. Evolutionally conserved plant homologues of the Bax Inhibitor-1 (BH-1) gene capable of suppressing Bax-induced cell death in yeast. FEBS Lett. 464, 143–147 (1999). · DOI
  53. Sanchez, P., de Torres Zabela, M. & Grant, M. AtBI-1, a plant homologue of Bax inhibitor-1, suppresses Bax-induced cell death in yeast and is rapidly upregulated during wounding and pathogen challenge. Plant J. 21, 393–399 (2000). · DOI
  54. Devoto, A. et al. Topology, subcellular localization and sequence diversity of the Mlo family in plants. J. Biol. Chem. 274, 34993–35004 (1999). · DOI · Paper page
  55. Clarke, A., Desikan, R., Hurst, R. D Hancock, J. T. & Neill, S. J. NO way back: nitric oxide and programmed cell death in Arabidopsis thaliana suspension cultures. Plant J. 24, 667–677 (2000). · DOI · Paper page
  56. Mittler, R. Shulaev, V. & Lam, E. Coordinated activation of programmed cell death and defense mechanisms in transgenic tobacco plants expressing a bacterial proton pump. Plant Cell 7, 29–42 (1995). · doi:10.1105/tpc.7.1.29
  57. Kampranis, S. C. et al. A novel plant glutathione S-transferase:peroxidase suppresses Bax lethality in yeast. J. Biol. Chem. 275, 29207–29216 (2000). · DOI · Paper page
  58. Harris, M. H., Vander Heiden, M. G., Kron, S. J. & Thompson, C. B. Role of oxidative phosphorylation in Bax toxicity. Mol. Cell. Biol. 20, 3590–3596 (2000). · DOI
  59. Gottlieb, E., Vander Heiden, M. G. & Thompson, C. B. Bcl-xL prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis. Mol. Cell. Biol. 20, 5680–5689 (2000). · DOI · Paper page
  60. Smith, N. A. et al. Total silencing by intron-spliced hairpin RNAs. Nature 407, 319–320 (2000). · DOI · Paper page
  61. McCabe, P. F., Levine, A, Meijer, P.-J., Tapon, N. A. & Pennell, R. I. A programmed cell death pathway activated in carrot cells at low density. Plant J. 12, 267–280 (1997). · doi:10.1046/j.1365-313x.1997.12020267.x
  62. Gao, M. & Showalter, A. M. Yariv reagent treatment induces programmed cell death in Arabidopsis cell cultures and implicates arabinogalactan protein involvement. Plant J. 19, 321–331 (1999). · DOI · Paper page

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Metadata

Authors
Lam, E., Kato, N., & Lawton, M.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2001-06
Volume
411
Issue
6839
Pages
848-853
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/35081184
OpenAlex
W2004689990
Cited by
900
References
1
FWCI
17.70
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)

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Lam, E., Kato, N., & Lawton, M. (2001). Programmed cell death, mitochondria and the plant hypersensitive response. Nature. https://doi.org/10.1038/35081184

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