Cited by 648Evolution and Genetic DynamicsOrigins and Evolution of LifeRNA and protein synthesis mechanisms

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An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule.

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Mills, D R, Peterson, R L, Spiegelman, S·1967·Proceedings of the National Academy of Sciences

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Abstract

Understanding a visual scene is an unsolved and daunting task, since scenes can contain a large number of objects, their properties, and interrelations. Extracting the full scene structure is therefore infeasible, but often unnecessary, since ...In modeling vision, there has been a remarkable progress in recognizing a range of scene components, but the problem of analyzing full scenes, an ultimate goal of visual perception, is still largely open. To deal with complete scenes, recent work focused ...

Integrity signals

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Specific template requirments of RNA replicases.
Haruna, I., & Spiegelman, S. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.2.579 · Cited by 220
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THE SELECTIVE SYNTHESIS OF INFORMATIONAL RNA IN BACTERIA
Hayashi, M., & Spiegelman, S. (1961) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.47.10.1564 · Cited by 212
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The synthesis of a self-propagating and infectious nucleic acid with a purified enzyme.
Spiegelman, S., Haruna, I., Holland, I. B., Beaudreau, G. S., & Mills, D. C. B. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.3.919 · Cited by 188
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AN RNA „REPLICASE” INDUCED BY AND SELECTIVE FOR A VIRAL RNA: ISOLATION AND PROPERTIES
Haruna, I., Nozu, K., Ohtaka, Y., & Spiegelman, S. (1963) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.50.5.905 · Cited by 155
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Comparison of Two Serologically Distinct Ribonucleic Acid Bacteriophages I. Properties of the Viral Particles
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Autocatalytic Synthesis of a Viral RNA in vitro
Haruna, I., & Spiegelman, S. (1965) · Science · doi:10.1126/science.150.3698.884 · Cited by 126
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Recognition of size and sequence by an RNA replicase.
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In Vitro Synthesis of an Infectious Mutant RNA with a Normal RNA Replicase
Pace, N. R., & Spiegelman, S. (1966) · Science · doi:10.1126/science.153.3731.64 · Cited by 42
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Über infektiöse substrukturen aus Escherichia coli bakteriophagen
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The dissociation of Q-beta-replicase and the relation of one of the components to a poly-C-dependent poly-G-polymerase.
Eikhom, T. S., & Spiegelman, S. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.57.6.1833 · Cited by 39
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Authors: Mills, D. R., Peterson, R. L., & Spiegelman, S.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1967-07
Volume: 58
Issue: 1
Pages: 217-224
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.58.1.217
PMC: PMC335620
OpenAlex: W2112864600
Cited by: 648
References: 13
Citations by year: 2026: 20 · 2025: 16 · 2024: 33 · 2023: 25 · 2022: 23 · 2021: 23 · 2020: 25 · 2019: 26 · 2018: 25 · 2017: 22 · 2016: 18 · 2015: 22 · 2014: 12 · 2013: 15 · 2012: 19
FWCI: 11.66
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Profiles in Science (submittedVersion, public-domain)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: Darwinian evolution, in vitro evolution, RNA self-replication, origin of life
MeSH terms: Coliphages, Electrophoresis, Biological Evolution, Kinetics, Molecular Weight, Phosphorus Isotopes, RNA, Viral, Ultracentrifugation

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An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule.

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