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The Wavelengths in Sunlight Effective in Producing Skin Cancer: A Theoretical Analysis
Open accessAbstract
DNA is taken as the target for skin cancer induced by ultraviolet light, and the known data on the sensitivity of DNA as a function of wavelength are summarized. The sun's spectrum at the surface of the earth and the DNA action spectrum are used to calculate the carcinogenic effectiveness as a function of wavelength. The most effective wavelengths at 30°N latitude are <305 nm, and a 1% change in atmospheric ozone results in a 2% change in the effective dose of ultraviolet light. Since both the basic biological and physical data are reasonably precise, the major requirement for a quantitative evaluation of the dose response relation for ultraviolet-induced skin cancer in man is better epidemiological data to compare with data from animal models.
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“In addition, relevant UVRinduced DNA damage markers such as cyclobutene pyrimidine dimers cannot be measured in SC tapes (Kraemer, 1997;Setlow, 1974).”
From Effect of Repeated Low-Dose UVR Exposure on Skin Inflammation Threshold, Skin Biomarkers, and Vitamin D in Healthy Adults (2025) · cites this paper as Setlow, 1974
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Gamma-ray bursts and terrestrial planetary atmospheres
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Ultraviolet limit of solar radiation at the earth's surface with a photon counting monochromator
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Construction of spectral sensitivity function using polychromatic UV sources
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PROTECTION FROM VISIBLE LIGHT DAMAGE TO ENZYMES AND TRANSPORT IN ESCHERICHIA COLI*
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Metadata
- Authors
- Setlow, R. B.
- Affiliations
- Oak Ridge National Laboratory (US)
- Corresponding author
- Setlow, R. B.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1974-09
- Volume
- 71
- Issue
- 9
- Pages
- 3363-3366
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC433772
- OpenAlex
- W2092873988
- Cited by
- 1,125
- References
- 20
- Citations by year
- 2026: 12 · 2025: 6 · 2024: 13 · 2023: 14 · 2022: 13 · 2021: 14 · 2020: 23 · 2019: 13 · 2018: 18 · 2017: 17 · 2016: 20 · 2015: 19 · 2014: 21 · 2013: 18 · 2012: 21
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
- Keywords
- ultraviolet radiation, skin cancer, solar spectrum, atmospheric ozone, dose-response relationship, UV-induced DNA damage, latitude effects
- MeSH terms
- DNA, Dose-Response Relationship, Radiation, Environmental Exposure, Models, Biological, Ozone, Photochemistry, Radiation Injuries, Skin Neoplasms, Sunlight, Ultraviolet Rays
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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