Brownian motion in biological membranes
Open accessAbstract
Brownian motion (diffusion) of particles in membranes occurs in a highly anisotropic environment. For such particles a translational mobility (independent of velocity) can be defined if the viscosity of the liquid embedding the membrane is taken into account. The results of a model calculation are presented. They suggest that for a realistic situation translational diffusion should be about four times faster in relation to rotational diffusion than in the isotropic case.
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For flat membranes, Saffman and Delbruck predicted a logarithmic dependence of the diffusion coefficient with the "size" of the membrane, relative to the size of the protein.
“For flat membranes, Saffman and Delbruck (1975) predicted a logarithmic dependence of the diffusion coefficient with the “size” of the membrane, relative to the size of the protein.”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Saffman and Delbruck (1975)
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“For flat membranes, Saffman and Delbruck (1975) predicted a logarithmic dependence of the diffusion coefficient with the “size” of the membrane, relative to the size of the protein.”
‘Assembly and analysis of cell-scale membrane envelopes’
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- Authors
- Saffman, P. G., & Delbrück, M.
- Affiliations
- California Institute of Technology (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1975-08
- Volume
- 72
- Issue
- 8
- Pages
- 3111-3113
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC432930
- OpenAlex
- W1972859350
- Cited by
- 1,773
- References
- 0
- Citations by year
- 2026: 25 · 2025: 55 · 2024: 46 · 2023: 52 · 2022: 57 · 2021: 62 · 2020: 54 · 2019: 66 · 2018: 68 · 2017: 102 · 2016: 54 · 2015: 70 · 2014: 67 · 2013: 57 · 2012: 82
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Physical Sciences › Chemistry › Spectroscopy › Diffusion Coefficients in Liquids
- Physical Sciences › Mathematics › Modeling and Simulation › Fractional Differential Equations Solutions
- Keywords
- Brownian motion, membrane diffusion, biological membranes, translational diffusion, rotational diffusion, anisotropic environments, translational mobility, membrane viscosity, membrane fluidity
- MeSH terms
- Animals, Anura, Biological Transport, Cell Membrane, Diffusion, Mathematics, Membranes, Models, Biological, Photoreceptor Cells, Protein Conformation, Rhodopsin, Viscosity
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