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Purkinje cell degeneration, a new neurological mutation in the mouse.
Open accessAbstract
A new autosomal recessive mouse mutation, Purkinje cell degeneration (pcd), is described. Mutants exhibit a moderate ataxia beginning at 3 to 4 weeks of age. The ataxia results from postnatal degeneration of virtually all cerebellar Purkinje cells beginning around 15 to 18 days of age and progressing rapidly over the next 2 weeks. In addition to the cerebellar disease there is slow progressive degeneration in the retina (photoreceptor cells) and olfactory bulb. Also, adult males have abnormal sperm.
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Citations
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Metadata
- Authors
- Mullen, R. J., Eicher, E. M., & Sidman, R. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-01
- Volume
- 73
- Issue
- 1
- Pages
- 208-212
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2017689311
- Cited by
- 610
- References
- 0
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Purkinje cell degeneration, a new neurological mutation in the mouse. https://app.cochat.ai/papers/10.1073/pnas.73.1.208
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- Mullen, R. J., Eicher, E. M., & Sidman, R. L. (1976). Purkinje cell degeneration, a new neurological mutation in the mouse. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.1.208
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
