The DOI matches its Crossref record.
Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice
Open accessAbstract
Several immunologic features were analyzed in mice on a zinc-deficient diet [Zn(-)], in mice pair-fed a diet containing zinc [Zn(+)], in mice fed a Zn(+) diet ad lib, and in mice fed laboratory chow ad lib. When placed on a Zn(-) diet, 6- to 8-week-old A/Jax, C57BL/Ks, and CBA/H mice showed loss of body weight, low lymphoid tissue weight, and profound involution of the thymus within 4-8 weeks after initiation of the regimen. Approximately 50% of the mice on the Zn(-) diet developed severe acrodermatitis enteropathica (lesions on tail and paws) and diarrhea. Pair-fed mice on the Zn(+) diet did not show any of these symptoms. Mice on the Zn(-) diet showed the following immune deficiencies: ( i ) depressed plaque-forming cells against sheep erythrocytes after in vivo immunization; ( ii ) depressed T killer cell activity against EL-4 tumor cells after in vivo immunization; and ( iii ) low natural killer cell activity. However, antibody-dependent cell-mediated cytotoxicity against chicken erythrocytes was normal in the mice on the Zn(-) diet. Deficiency of T killer cell activity was not observed when immunization with EL-4 allogeneic lymphoma cells was carried out in vitro . Progressive loss of relative and absolute number of Thy 1.2+ cells and a proportionate relative increase in cells bearing Fc receptors was seen in spleen and lymph nodes of Zn(-) animals. It appears that zinc is an essential element for maintenance of normal T cell and other immune functions in vivo .
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Cited by
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Shankar, A. H., & Prasad, A. S. (1998) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.447s · Cited by 1,606
Reprogramming of the immune system during zinc deficiency
Fraker, P. J., & King, L. E. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132454 · Cited by 470
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Prasad, A. S. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.10.013 · Cited by 454
Influence of Stress and Nutrition on Cattle Immunity
Carroll, J. A., & Forsberg, N. E. (2007) · Veterinary Clinics of North America: Food Animal Practice · doi:10.1016/j.cvfa.2007.01.003 · Cited by 337
Zinc: Mechanisms of Host Defense1,
Prasad, A. S. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.5.1345 · Cited by 314
Ogawa, Y., Kinoshita, M., Shimada, S., & Kawamura, T. (2018) · Nutrients · doi:10.3390/nu10020199 · Cited by 214
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Pharmaconutrition Review: Physiological Mechanisms
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Metadata
- Authors
- Fernandes, G., Nair, M., Onoe, K., Tanaka, T., Floyd, R., & Good, R. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-01
- Volume
- 76
- Issue
- 1
- Pages
- 457-461
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1983950526
- Cited by
- 336
- References
- 0
- FWCI
- 18.08
- Type
- journal article
- Language
- en
- Open access
- green
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