The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.
Open accessAbstract
Leukotrienes B4, C4, and D4, members of a recently discovered family of substances biosynthesized from arachidonic acid, were found to have potent microvascular actions in the hamster cheek pouch. When applied topically to the vascular network, leukotrienes C4 and D4 caused an intense constriction of arterioles, being similar to angiotensin in potency in this respect. The vasoconstriction induced by leukotrienes C4 and D4 was short-lived, and it was consistently followed by a marked and dose-dependent extravasation of macromolecules from postcapillary venules. Histamine did not constrict arterioles, but it elicited leakage of plasma, although on a molar basis it was no more than 1/1000th as potent as the leukotrienes. When used in the same concentration range as leukotrienes C4 and D4, leukotriene B4 did not evoke vasoconstriction or promote plasma leakage. On the other hand, leukotriene B4 caused a conspicuous and reversible adhesion of leukocytes to the endothelium in postcapillary venules. Our findings that leukotrienes induce microcirculatory alterations in vivo, closely resembling the early events in the acute inflammatory response, imply that leukotrienes, formed in several blood-borne and tissue-bound cells, may mediate important microcirculatory adjustments to noxious stimuli.
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Self-citationLeukotrienes are potent constrictors of human bronchi
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Self-citationENDOTHELIAL CONTRACTION INDUCED BY HISTAMINE-TYPE MEDIATORS
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Lewis (1990) · doi:10.1056/nejm199009063231006 · Cited by 1,200
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Sibille, Y., & Reynolds, H. Y. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.2.471 · Cited by 1,083
Phagocyte partnership during the onset and resolution of inflammation
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Metadata
- Authors
- Dahlén, S. E., Björk, J., Hedqvist, P., Arfors, K. E., Hammarström, S., Lindgren, J. A., & Samuelsson, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-06
- Volume
- 78
- Issue
- 6
- Pages
- 3887-3891
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1972439638
- Cited by
- 1,019
- References
- 20
- FWCI
- 51.17
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response. https://app.cochat.ai/papers/10.1073/pnas.78.6.3887
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- Dahlén, S. E., Björk, J., Hedqvist, P., Arfors, K. E., Hammarström, S., Lindgren, J. A., & Samuelsson, B. (1981). Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.6.3887
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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