The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Distinct cholecystokinin receptors in brain and pancreas.
Open accessAbstract
125I-Labeled (Bolton-Hunter) cholecystokinin triacontatriapeptide (CCK-33) binds saturably and reversibly to distinct receptors in brain and pancreatic membranes. The peptide specificity of pancreatic CCK binding is the same as that for pancreatic amylase release. In brain, gastrin and pentagastrin display nanomolar affinity for binding sites, whereas in pancreas these two peptides are virtually inactive. Though these differences indicate that brain and pancreas possess distinct CCK receptors, the two tissues show some similarities. Both pancreas and brain receptors show greater sensitivity to sulfated than to desulfated COOH-terminal octapeptide of CCK and display dissociation constants of 0.3-9.5 nM. The pancreas possesses about 300 times more binding sites than does brain. CCK binding in both brain and pancreas is enhanced by divalent cations and reduced by monovalent cations. Receptor binding in both tissues is regulated in a selective fashion by guanyl nucleotides.
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Cites
Endogenous opioid peptides: multiple agonists and receptors
Lord, J. A. H., Waterfield, A. A., Hughes, J., & Kosterlitz, H. W. (1977) · Nature · doi:10.1038/267495a0 · Cited by 2,485
Cited by
Lee, J. H., Kim, S.-Y., Kwon, Y. K., Kim, B. J., & So, I. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350075 · Cited by 1,380
Rezayat, M., Roohbakhsh, A., Zarrindast, M.-R., Massoudi, R., & Djahanguiri, B. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.03.002 · Cited by 82
Wu, C.-L., Hung, C.-R., Chang, F.-Y., Francis Pau, K.-Y., & Wang, P. S. (2003) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-003-0690-y · Cited by 51
Some Aspects on the Anatomy and Function of Central Cholecystokinin Systems
Hökfelt, T., Blacker, D., Broberger, C., Herrera‐Marschitz, M., Snyder, G., Fisone, G., Cortés, R., Morino, P., You, Z., & Ögren, S. O. (2002) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2002.910617.x · Cited by 33
Wu, C.-L., Doong, M.-L., & Wang, P. S. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.024 · Cited by 27
Metadata
- Authors
- Innis, R. B., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-11
- Volume
- 77
- Issue
- 11
- Pages
- 6917-6921
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2066944012
- Cited by
- 573
- References
- 1
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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