Cholecystokinin and GABA interaction in the dorsal hippocampus of rats in the elevated plus-maze test of anxiety
Abstract
In the present study, we have investigated the effects and interaction of CCK and GABAergic systems in the dorsal hippocampus of rats using the elevated plus-maze test of anxiety. Bilateral injection of different doses of CCK(8s) (0.01, 0.05 and 0.1 microg/rat) into the dorsal hippocampus (intra-CA1) decreased percentage of open arm time (%OAT) and open arm entries (%OAE) that are representative of anxiogenic-like behavior. The bilateral injection of three doses of LY225910, a selective CCK2 receptor antagonist (0.01, 0.1 and 0.5 microg/rat) produced significant anxiolytic behavior. Although muscimol (GABA(A+)) (0.1, 0.5 and 1 microg/rat, intra-CA1) produced dose dependent increase in %OAT and a slight increase in %OAE, bicuculline (GABA(A-)), (1, 2 and 4 microg/rat, intra-CA1) failed to change the anxiety profile. Both muscimol (0.1 microg/rat) and bicuculline (1 microg/rat), when co-administered with LY225910, reversed the effect of latter drug on anxiety but when co-administered with CCK8s (0.05 microg/rat) showed no effect on anxiety profile. In conclusion, it seems that both CCK and GABAergic systems not only play a part in the modulation of anxiety in the dorsal hippocampus of rats but also have demonstrated a complex interaction as well.
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Both human and rodents studies indicate a positive correlation of CCK levels and increased anxiety-like behavior.
“Both human and rodents studies indicate a positive correlation of CCK levels and increased anxiety-like behavior [273-275].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [274]
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- Authors
- Rezayat, M., Roohbakhsh, A., Zarrindast, M.-R., Massoudi, R., & Djahanguiri, B.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 84
- Issue
- 5
- Pages
- 775-782
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2057855185
- Cited by
- 82
- References
- 49
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 8 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 5
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- cholecystokinin, GABAergic system, dorsal hippocampus, anxiety, CCK-8, muscimol, bicuculline, anxiolytic effects, anxiogenic behavior, hippocampal CA1, drug interactions
- MeSH terms
- Animals, Anxiety, Bicuculline, Cholecystokinin, Dose-Response Relationship, Drug, gamma-Aminobutyric Acid, Hippocampus, Male, Microinjections, Quinazolines, Receptors, Cholecystokinin, Stereotaxic Techniques, Rats, Wistar, GABA Antagonists, Receptor, Cholecystokinin B, Rats, Quinazolinones
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