The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: Functional significance of coexisting transmitters for vasodilation and secretion
Open accessAbstract
By a combination of the indirect immunofluorescence technique with acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) staining, it was shown that vasoactive intestinal polypeptide (VIP) is present in cholinergic (acetylcholinesterase-rich) neurons involved in control of secretion and vasodilation in exocrine glands of cat. The submandibular salivary gland was used as a functional model. Preganglionic nerve stimulation induced an atropine-resistant, hexamethonium-sensitive vasodilation and release of VIP into the venous outflow from the gland and an atropine- and hexamethonium-sensitive secretion. Infusion of VIP antiserum reduced both the vasodilation and secretion. Infusion of VIP caused vasodilation only, whereas acetylcholine caused both vasodilation and secretion. Simultaneous infusion of VIP and acetylcholine in low doses resulted in a marked potentiation of both vasodilation and secretion. The present morphological and functional data support the following hypothesis for regulation of vasodilation and secretion in exocrine glands. Preganglionic cholinergic nerves activate, via nicotinic receptors, postganglionic neurons, causing concomitant release from the same nerve endings of two coexisting putative transmitters, acetylcholine and VIP. Acetylcholine produces mainly secretion by a muscarinic action and VIP causes mainly vasodilation, but the two substances seem to cooperate directly or indirectly in both types of response. Thus, the coexistence of two putative neurotransmitters, VIP and acetylcholine, in one neuron may explain the dual effector response (i.e., the cholinergic secretion and the atropine-resistant vasodilation) caused by nerve stimulation in exocrine glands.
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Bardawil, W. A., & Toy, B. L. (1969) · American Journal of Clinical Pathology · doi:10.1093/ajcp/52.1.99b · Cited by 1,562
Localization of vasoactive intestinal polypeptide (VIP) to central and peripheral neurons.
Larsson, L. I., Fahrenkrug, J., Schaffalitzky De Muckadell, O., Sundler, F., Håkanson, R., & Rehfeld, J. R. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.9.3197 · Cited by 616
Self-citationGeneser-Jensen, F. A., & Blackstad, T. W. (1971) · Zeitschrift f�r Zellforschung und Mikroskopische Anatomie · doi:10.1007/bf00325634 · Cited by 611
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Self-citationBryant, M. G., Bloom, S. R., Polar, J. M., Albuquerque, R. H., Modlin, I., & Pearse, A. G. E. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91863-8 · Cited by 492
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Self-citationRadioimmunoassay of Vasoactive Intestinal Polypeptide (VIP) in Plasma
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Self-citation
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Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Rosenfeld, M. G., Mermod, J.-J., Amara, S. G., Swanson, L. W., Sawchenko, P. E., Rivier, J., Vale, W. W., & Evans, R. M. (1983) · Nature · doi:10.1038/304129a0 · Cited by 2,302
Neuropeptide and small transmitter coexistence: Fundamental studies and relevance to mental illness
Hökfelt, T., Barde, S., Xu, Z.-Q. D., Kuteeva, E., Rüegg, J., Le Maitre, E., Risling, M., Kehr, J., Ihnatko, R., Theodorsson, E., et al. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00106 · Cited by 139
Thermoregulatory and thermal control in the human cutaneous circulation
Kellogg, D. L. (2010) · Frontiers in Bioscience · doi:10.2741/s105 · Cited by 137
Metadata
- Authors
- Lundberg, J. M., Änggärd, A., Fahrenkrug, J., Hökfelt, T., & Mutt, V.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-03
- Volume
- 77
- Issue
- 3
- Pages
- 1651-1655
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2001211531
- Cited by
- 481
- References
- 17
- FWCI
- 9.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Lundberg, J. M., Änggärd, A., Fahrenkrug, J., Hökfelt, T., & Mutt, V. (1980). Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: Functional significance of coexisting transmitters for vasodilation and secretion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.3.1651
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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