CoChat
Sign Up
Cited by 137Thermoregulation and physiological responsesCardiovascular and exercise physiologyHeart Rate Variability and Autonomic Control

Thermoregulatory and thermal control in the human cutaneous circulation

Open access
Kellogg, Dean L·2010·Frontiers in Bioscience
DOI 10.2741/s105
Open this paper in CoChat — free accountOpen PDF

Abstract

The past 10-15 years has been a time of focus on the mechanisms of control in the human cutaneous circulation. Methodological developments have provided powerful means for resolving the important contributors to the reflex control of skin blood flow (thermoregulatory control) and also for the equally impressive effects of direct heating and cooling of the skin (thermal control). This review is devoted largely to that recent literature. We treat the sympathetic vasoconstrictor system and its transmitters and modulatory factors and the sympathetic active vasodilator system and its abundant mysteries, with focus on the putative transmitters and cotransmitters, the involvement of nitric oxide and the relationship to sweating and modulatory factors. We also deal with the current understanding of the mechanisms of vasoconstriction and vasodilation that accompany direct skin cooling and heating, noting that adrenergic function, afferent nerve function and the nitric oxide system are involved in the vascular responses to both thermal stimuli.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2741/s105

Cites

182 of 182 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Skin temperature is modulated by environmental temperature and by endogenous central and autonomic nervous system processes that actively regulate blood flow through the skin.

    “Skin temperature is modulated by environmental and endogenous processes. The human skin is under the influence of environmental temperature. In addition, skin temperature depends on endogenous central and autonomic nervous system processes that actively regulate blood flow through the skin (reviewed in [43]).”

    From Sleep, vigilance, and thermosensitivity (2012) · cites this paper as [43]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. JM Lundberg, A Franco-Cerecda, Y Lou, A Modin, J Pernow. Differential release of classical transmitters and peptides In: Molecular and Cellular Mechanisms of Neurotransmitter Release Eds: L Stjårne, P Greengard, S Grillner, T Hökfelt, D Ottoson Raven Press, Ltd, New York (1994)

Cited by

Sorted by citations

Related

Authors
Kellogg, D. L.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
Corresponding author
Kellogg, Dean L
ORCID
Kellogg, Dean L
Venue
Frontiers in Bioscience
Publisher
IMR Press
Published
2010
Volume
S2
Issue
3
Pages
825-853
ISSN
  • 1944-7906 (ISSN-L)
  • 1945-0516
  • 1945-0524
DOI
10.2741/s105
OpenAlex
W1484219020
Cited by
137
References
182
Citations by year
2026: 3 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 10 · 2017: 4 · 2016: 11 · 2015: 18 · 2014: 16 · 2013: 8 · 2012: 8
FWCI
0.84
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Bioscience-Scholar (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Kellogg's
  • National Heart, Lung, and Blood Institute (R01HL059166, HL 65599, R01HL065599, HL-059166)
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
thermoregulation, skin blood flow, thermal management, nitric oxide, sweating, adrenergic function, skin cooling, skin heating, vasoconstriction, vasodilation, co-transmitter
MeSH terms
Animals, Body Temperature Regulation, Female, Humans, Iontophoresis, Male, Neuropeptide Y, Nitric Oxide, Norepinephrine, Reflex, Skin, Substance P, Sweating, Sympathetic Nervous System, Vasoactive Intestinal Peptide, Vasoconstriction, Vasodilation, Laser-Doppler Flowmetry, Microdialysis, Botulinum Toxins, Type A, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review