The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Spontaneous cancer and its possible relationship to oxygen metabolism.
Open accessAbstract
Mortality statistics for cancer in various countries and periods of time indicate that there has been little effect of industrialization on the inherent or spontaneous rate of occurrence of cancer. From U.S. cancer statistics and the BEIR values [Report of the Advisory Committee on the Biological Effects of Ionizing Radiation (1979)] for radiation dose response, the ionizing radiation exposure required to produce a number of cancers equal to this spontaneous incidence was estimated to lie between 450 and 2100 rads (1 rad = 0.01 J/kg). From these "cancer equivalent" doses the number of single-strand DNA breaks required to produce the spontaneous cancers is estimated to be 0.26-1.3 per cell DNA per day. It is suggested that the univalent reduction of oxygen in normal metabolism to O2- and subsequent production of more harmful radicals is the source of the DNA defects that, in cases where the defense mechanisms fail, lead to spontaneous cancer in the individual.
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Cites
Fridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329
Cited by
WISEMAN, H., & HALLIWELL, B. (1996) · Biochemical Journal · doi:10.1042/bj3130017 · Cited by 2,345
β-Carotene: an Unusual Type of Lipid Antioxidant
Burton, G. W., & Ingold, K. U. (1984) · Science · doi:10.1126/science.6710156 · Cited by 2,150
Oxygen radicals and human disease
CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856
DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems
Halliwell, B., & Aruoma, O. I. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80347-6 · Cited by 1,537
Oxidative stress and cancer: Have we moved forward?
Halliwell, B. (2007) · Biochemical Journal · doi:10.1042/bj20061131 · Cited by 1,302
Metadata
- Authors
- Totter, J. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-04
- Volume
- 77
- Issue
- 4
- Pages
- 1763-1767
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2025824008
- Cited by
- 296
- References
- 1
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
