The DOI matches its Crossref record.
Herpes simplex type 1 DNA in human brain tissue.
Open accessAbstract
Herpes simplex virus type 1 (HSV-1) is known to reside latently in the trigeminal ganglia of man. Reactivation of this virus causes skin lesions and may occasionally infect other tissues, including the brain. To determine whether the brain tissue of humans free of clinical signs of HSV-1 infection contains any trace of HSV-1, we examined the DNA from brain tissue by endonuclease digestion, separation of the fragments by gel electrophoresis, and hybridization with labeled HSV-1 DNA probes. Hybrid bands were detected autoradiographically in experiments using cloned and virion-purified fragments of the HSV-1 genome. HSV-1 DNA sequences were found in 6 of 11 human brain DNA samples tested. In some cases, these bands corresponded to the bands expected for the complete viral genome, whereas others contained bands representing only a part of the genome. In some cases, the terminal fragments could be found, suggesting that the DNA was in a linear, nonintegrated form.
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Cited by
Rock, D. L., Nesburn, A. B., Ghiasi, H., Ong, J., Lewis, T. L., Lokensgard, J. R., & Wechsler, S. L. (1987) · Journal of Virology · doi:10.1128/jvi.61.12.3820-3826.1987 · Cited by 355
Latent herpes simplex virus type 1 in normal and Alzheimer's disease brains
Jamieson, G. A., Maitland, N. J., Wilcock, G. K., Craske, J., & Itzhaki, R. F. (1991) · Journal of Medical Virology · doi:10.1002/jmv.1890330403 · Cited by 332
Latent Herpes Simplex Virus in Human Trigeminal Ganglia
Croen, K. D., Ostrove, J. M., Dragovic, L. J., Smialek, J. E., & Straus, S. E. (1987) · New England Journal of Medicine · doi:10.1056/nejm198712033172302 · Cited by 320
Herpes Simplex Virus-1 in the Brain: The Dark Side of a Sneaky Infection
Marcocci, M. E., Napoletani, G., Protto, V., Kolesova, O., Piacentini, R., Li Puma, D. D., Lomonte, P., Grassi, C., Palamara, A. T., & De Chiara, G. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.03.003 · Cited by 303
Inhibition of HSV-1 Replication by Gene Editing Strategy
Roehm, P. C., Shekarabi, M., Wollebo, H. S., Bellizzi, A., He, L., Salkind, J., & Khalili, K. (2016) · Scientific Reports · doi:10.1038/srep23146 · Cited by 128
Metadata
- Authors
- Fraser, N. W., Lawrence, W. C., Wroblewska, Z., Gilden, D. H., & Koprowski, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-10
- Volume
- 78
- Issue
- 10
- Pages
- 6461-6465
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1988030420
- Cited by
- 255
- References
- 0
- FWCI
- 14.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Fraser, N. W., Lawrence, W. C., Wroblewska, Z., Gilden, D. H., & Koprowski, H. (1981). Herpes simplex type 1 DNA in human brain tissue. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.10.6461
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