The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1
Open accessAbstract
Using a combination of in situ hybridization and Northern (RNA) blot analysis, we investigated herpes simplex virus type 1 (HSV-1) transcriptional activity in an ocular rabbit model of HSV-1 latency. Radioactively labeled cloned fragments, representing virtually the entire HSV-1 genome, were individually hybridized to RNA in sections of trigeminal ganglia taken from rabbits during the latent phase of infection with HSV-1 (McKrae). Our results suggest that two discrete latency-related RNAs (LR-RNAs) may be present. The LR-RNAs were localized mainly in the nuclei of neurons. The more abundant LR-RNA was detected in approximately 3% of all neurons examined and was designated major LR-RNA. The other LR-RNA, designated minor LR-RNA, was detected in approximately 0.3% of neurons from latently infected rabbits. The genes for the LR-RNAs mapped in the vicinity of the immediate-early gene ICP0 (also designated IE110). The gene for the major LR-RNA partially overlapped the left (3') end of the ICP0 gene. In situ hybridization with single-stranded RNA probes showed that this LR-RNA was of complementary sense to that of ICP0 mRNA. Northern blot analysis gave an approximate size for this LR-RNA of 1.8 to 2.2 kilobases. The minor LR-RNA mapped to or near the right (5') end of the ICP0 gene. The detection of LR-RNAs suggests the possibility that these RNAs or their products may play significant roles in the initiation and/or maintenance of HSV-1 latency.
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Cites
Molecular Cloning: A Laboratory Manual
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RNA Complementary to a Herpesvirus α Gene mRNA Is Prominent in Latently Infected Neurons
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Detection of HSV-1 genome in central nervous system of latently infected mice
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Cloning of herpes simplex virus type 1 sequences representing the whole genome
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Characterization of the IE110 Gene of Herpes Simplex Virus Type 1
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Ocular pathogenicity of herpes simplex virus
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Cited by
The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1
McGeoch, D. J., Dalrymple, M. A., Davison, A. J., Dolan, A., Frame, M. C., McNab, D., Perry, L. J., Scott, J. E., & Taylor, P. (1988) · Journal of General Virology · doi:10.1099/0022-1317-69-7-1531 · Cited by 1,618
Virus-Induced Neuronal Apoptosis Blocked by the Herpes Simplex Virus Latency-Associated Transcript
Perng, G.-C., Jones, C., Ciacci-Zanella, J., Stone, M., Henderson, G., Yukht, A., Slanina, S. M., Hofman, F. M., Ghiasi, H., Nesburn, A. B., et al. (2000) · Science · doi:10.1126/science.287.5457.1500 · Cited by 469
Self-citationChromatin control of herpes simplex virus lytic and latent infection
Knipe, D. M., & Cliffe, A. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1794 · Cited by 444
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The molecular basis of herpes simplex virus latency
Nicoll, M. P., Proença, J. T., & Efstathiou, S. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00320.x · Cited by 286
Metadata
- Authors
- Rock, D. L., Nesburn, A. B., Ghiasi, H., Ong, J., Lewis, T. L., Lokensgard, J. R., & Wechsler, S. L.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1987-12
- Volume
- 61
- Issue
- 12
- Pages
- 3820-3826
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2104845462
- Cited by
- 355
- References
- 10
- FWCI
- 22.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Rock, D. L., Nesburn, A. B., Ghiasi, H., Ong, J., Lewis, T. L., Lokensgard, J. R., & Wechsler, S. L. (1987). Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1. Journal of Virology. https://doi.org/10.1128/jvi.61.12.3820-3826.1987
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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